HE3235
- CAS No.
- 183387-50-0
- Chemical Name:
- HE3235
- Synonyms
- HE3235;Apoptone;Pregn-20-yne-3,17-diol, (3α,5α,17α)-;(3R,5S,8R,9S,10S,13S,14S,17R)-17-ethynyl-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,14,15,16-tetradecahydrocyclopenta[a]phenanthrene-3,17-diol
- CBNumber:
- CB72627947
- Molecular Formula:
- C21H32O2
- Molecular Weight:
- 316.49
- MDL Number:
- MFCD25976822
- MOL File:
- 183387-50-0.mol
| Boiling point | 430.1±18.0 °C(Predicted) |
|---|---|
| Density | 1.11±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | ≤10mg/ml in ethanol;10mg/ml in DMSO;10mg/ml in dimethyl formamide |
| form | crystalline solid |
| pka | 13.11±0.70(Predicted) |
| FDA UNII | 891O182ZP5 |
HE3235 price More Price(8)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 9002769 | HE-3235 ≥95% | 183387-50-0 | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 9002769 | HE-3235 ≥95% | 183387-50-0 | 5mg | $139 | 2024-03-01 | Buy |
| Cayman Chemical | 9002769 | HE-3235 ≥95% | 183387-50-0 | 10mg | $243 | 2024-03-01 | Buy |
| Cayman Chemical | 9002769 | HE-3235 ≥95% | 183387-50-0 | 25mg | $533 | 2024-03-01 | Buy |
| ApexBio Technology | C3546 | HE-3235 | 183387-50-0 | 25mg | $608 | 2021-12-16 | Buy |
HE3235 Chemical Properties,Uses,Production
Description
HE-3235 is a synthetic adrenal hormone, an androstanediol analog, that acts as an androgen receptor antagonist. In an androgen receptor-dependent manner, it downregulates anti-apoptotic genes, while increasing the expression of pro-apoptotic genes, thus stimulating apoptosis. HE-3235 has been shown to inhibit androstenediol-dependent LNCaP cell tumor growth both in vitro (IC50 = 6 nM) and in xenograft models in vivo.
in vitro
in lncap cells expressing a mutated androgen receptor, he3235 significantly inhibited activity for aed-stimulated lncap proliferation. this inhibitory activity is accompanied by an increase in the number of apoptotic cells [1].
in vivo
animal studies have confirmed the cytoreductive activity of he3235 on lncap tumours. the results suggest that this compound may be of clinical use in castration-resistant prostate cancer. in castrated male mice implanted subcutaneously with lucap35v cap xenografts, treatment with he3235 significantly prolonged the tumor doubling time of lucap35v, decreased androgen receptor expression, and lowered levels of intratumoral testosterone by 89% and dihydrotestosterone by 63% in both the presence and the absence of aed. he3235 inhibited tumor growth in the bone environment. he3235 inhibited the growth of subcutaneous crpc as well as crpc in the bone environment. he3235 exhibited a wide range of effects, including alteration of androgen receptor signaling and reductions in levels of intratumoral androgens. weights of tumored tibiae of he3235-treated animals were lower than those of control [3].
References
[1] trauger r, corey e, bell d, et al. inhibition of androstenediol-dependent lncap tumour growth by 17α-ethynyl-5α-androstane-3α, 17β-diol (he3235)[j]. british journal of cancer, 2009, 100(7): 1068-1072.
[2] gelmann e p. molecular biology of the androgen receptor[j]. journal of clinical oncology, 2002, 20(13): 3001-3015.[3 gelmann e p. molecular biology of the androgen receptor[j]. journal of clinical oncology, 2002, 20(13): 3001-3015.] koreckij t d, trauger r j, montgomery r b, et al. he3235 inhibits growth of castration-resistant prostate cancer[j]. neoplasia, 2009, 11(11): 1216in22-1225in23.
HE3235 Preparation Products And Raw materials
Raw materials
Preparation Products
HE3235 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| NCE Biomedical Co.,Ltd. | 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988 | China | 1494 | 55 | |
| SPIRO PHARMA | eric_feng1954@126.com | China | 9254 | 55 | |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8141 | 58 |
| Changzhou Furuisi Biotechnology Co., Ltd | 0519-85524369 | 3477467573@qq.com | China | 8618 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24018 | 58 |
| Suzhou Meishi Biotechnology Co., Ltd. | 1173954148q | meishipharma@126.com | China | 20035 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 8740 | 58 |
| ApexBio Technology | -- | sales@apexbt.com | United States | 6254 | 58 |