VidofludiMus
- CAS No.
- 717824-30-1
- Chemical Name:
- VidofludiMus
- Synonyms
- 4SC-101;CS-1196;SC12267);VidofludiMus;VidofludiMus(4SC-101;VIDOFLUDIMUS(4SC-101; SC12267);4SC-101; SC12267;4SC101;4SC 101;2-[(3-Fluoro-3'-methoxy-4-biphenylyl)carbamoyl]-1-cyclopentene-1-carboxylic acid;2-((3-Fluoro-3'-methoxy-[1,1'-biphenyl]-4-yl)carbamoyl)cyclopent-1-enecarboxylic acid;2-((3-Fluoro-3'-methoxy-[1,1'-biphenyl]-4-yl)carbamoyl)cyclopent-1-enecarboxylic acid
- CBNumber:
- CB72628520
- Molecular Formula:
- C20H18FNO4
- Molecular Weight:
- 355.36
- MDL Number:
- MFCD18633262
- MOL File:
- 717824-30-1.mol
- MSDS File:
- SDS
| Boiling point | 567.5±50.0 °C(Predicted) |
|---|---|
| Density | 1.354±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | insoluble in H2O; insoluble in EtOH; ≥103 mg/mL in DMSO |
| form | solid |
| pka | 4?+-.0.20(Predicted) |
| FDA UNII | 8Y1PJ3VG81 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P280-P305+P351+P338 | |||||||||
| NFPA 704 |
|
VidofludiMus price More Price(24)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 18377 | Vidofludimus ≥98% | 717824-30-1 | 1mg | $37 | 2024-03-01 | Buy |
| Cayman Chemical | 18377 | Vidofludimus ≥98% | 717824-30-1 | 5mg | $116 | 2024-03-01 | Buy |
| Cayman Chemical | 18377 | Vidofludimus ≥98% | 717824-30-1 | 10mg | $213 | 2024-03-01 | Buy |
| Cayman Chemical | 18377 | Vidofludimus ≥98% | 717824-30-1 | 25mg | $485 | 2024-03-01 | Buy |
| TRC | V305033 | Vidofludimus | 717824-30-1 | 25mg | $330 | 2021-12-16 | Buy |
VidofludiMus Chemical Properties,Uses,Production
Uses
Vidofludimus is an immunosuppressive drug that inhibits dihydroorotate dehydrogenase (DHODH) and the expression of proinflammatory cytokines including interleukin-17 (IL17A and IL17F) and interferon-gamma.
Biological Activity
vidofludimus (4sc-101, sc12267) is a novel small molecule inhibitor of dihydroorotate dehydrogenase (dhodh) with an ic50 value of 134nmol/l for human dhodh [1].vidofludimus (4sc-101, sc12267) has been reported to dose-dependently inhibit dhodh in an in vitro enzyme assay with ic50 values of 0.134μmol/l, 1.29μmol/l, 10.6μmol/l and 12.9μmol/l in human dhodh, rat dhodh, mouse dhodh and human pbmc, respectively [1]. in addition, vidofludimus has shown the inhibition of proliferation in phytohemagglutinin-induced lymphocytes with an ic50 value of ~13μmol/l. moreover, vidofludimus has been revealed to concentration-dependently inhibit phytohemagglutinin-stimulated interukin-17 secretion from human peripgeral blppd mononuclear cell lines (pbmcs) with an ic50 value of 6 μmol/l [2].
References
[1] kulkarni op1, sayyed sg, kantner c, ryu m, schnurr m, sárdy m, leban j, jankowsky r, ammendola a, doblhofer r, anders hj. 4sc-101, a novel small molecule dihydroorotate dehydrogenase inhibitor, suppresses systemic lupus erythematosus in mrl-(fas) lpr mice. am j pathol. 2010 jun;176(6):2840-7.
[2] fitzpatrick lr1, deml l, hofmann c, small js, groeppel m, hamm s, lemstra s, leban j, ammendola a. 4sc-101, a novel immunosuppressive drug, inhibits il-17 and attenuates colitis in two murine models of inflammatory bowel disease. inflamm bowel dis. 2010 oct;16(10):1763-77.
VidofludiMus Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| airuikechemical co., ltd. | +undefined86-15315557071 | sales02@airuikechemical.com | China | 994 | 58 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| WinWin Chemical CO., Limited | +86-0086-577-64498589 +86-15355981851 | sales@win-winchemical.com | China | 13854 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3136 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
View Lastest Price from VidofludiMus manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-07 | Vidofludimus
717824-30-1
|
US $0.00-0.00 / Kg | 1Kg | 99.9% | 200tons | airuikechemical co., ltd. | |
 |
2020-01-13 | VidofludiMus
717824-30-1
|
US $9.80 / KG | 1g | ≥99% | 100kg | Career Henan Chemical Co |
-
- Vidofludimus
717824-30-1
- US $0.00-0.00 / Kg
- 99.9%
- airuikechemical co., ltd.
-
- VidofludiMus
717824-30-1
- US $9.80 / KG
- ≥99%
- Career Henan Chemical Co