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Eplerenone EP Impurity A

CAS No.
209253-67-8
Chemical Name:
Eplerenone EP Impurity A
Synonyms
Eplerenone Impurity A;Eplerenone EP Impurity A;Eplerenone Impurity 6(Eplerenone EP Impurity A);(7α,17α)- 9,17-Dihydroxy-3-oxo-pregn-4-ene-7,21-dicarboxylic Acid Di-γ-lactone;(2''S)-3'',4''-Dihydro-3,5''-dioxospiro[androst-4-ene-17,2′-furan]-7α,9α-carbolactone;Pregn-4-ene-7,21-dicarboxylic acid, 9,17-dihydroxy-3-oxo-, 7,9:21,17-dilactone, (7α,17α)-;(2'R,7R,8R,9R,10S,13S,14S)-10,13-Dimethyl-7,8,11,12,13,14,15,16-octahydro-1H,3'H-spiro[9,7-(epoxymethano)cyclopenta[a]phenanthrene-17,2'-furan]-3,5',19(2H,4'H,6H,10H)-trione (Eplerenone Impurity)
CBNumber:
CB72645626
Molecular Formula:
C23H28O5
Molecular Weight:
384.47
MDL Number:
MOL File:
209253-67-8.mol
Last updated:2023-05-15 10:44:01

Eplerenone EP Impurity A Properties

Boiling point 632.9±55.0 °C(Predicted)
Density 1.31±0.1 g/cm3(Predicted)
solubility Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
form Solid
color White to Off-White
FDA UNII HB8V386D5U

Eplerenone EP Impurity A Chemical Properties,Uses,Production

Uses

(7a,17a)- 9,17-Dihydroxy-3-oxo-pregn-4-ene-7,21-dicarboxylic Acid Di-γ-lactone is an eplerenone (E588775) impurity. Eplerenone is a selective aldosterone receptor antagonist (SARA), structurally similar to Spiranolactone. Eplerenone is used alone or in combination with other medications to treat high blood pressure. Eplerenone is in a class of medications called mineralocorticoid receptor antagonists. It works by blocking the action of aldosterone, a natural substance in the body that raises blood pressure.

Eplerenone EP Impurity A Preparation Products And Raw materials

Raw materials

Preparation Products

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Eplerenone EP Impurity A Eplerenone Impurity A (7α,17α)- 9,17-Dihydroxy-3-oxo-pregn-4-ene-7,21-dicarboxylic Acid Di-γ-lactone Eplerenone Impurity 6(Eplerenone EP Impurity A) Pregn-4-ene-7,21-dicarboxylic acid, 9,17-dihydroxy-3-oxo-, 7,9:21,17-dilactone, (7α,17α)- (2''S)-3'',4''-Dihydro-3,5''-dioxospiro[androst-4-ene-17,2′-furan]-7α,9α-carbolactone (2'R,7R,8R,9R,10S,13S,14S)-10,13-Dimethyl-7,8,11,12,13,14,15,16-octahydro-1H,3'H-spiro[9,7-(epoxymethano)cyclopenta[a]phenanthrene-17,2'-furan]-3,5',19(2H,4'H,6H,10H)-trione (Eplerenone Impurity) 209253-67-8