2-(N-(5-chloro-2-Methylphenyl)MethylsulfonaMido)-N-(2,6-difluorophenyl)acetaMide
- CAS No.
- 708219-39-0
- Chemical Name:
- 2-(N-(5-chloro-2-Methylphenyl)MethylsulfonaMido)-N-(2,6-difluorophenyl)acetaMide
- Synonyms
- FPH1;CS-2645;BRD-6125;FPH1(BRD-6125);FPH1;BRD-6125;BRD 6125;BRD6125;inhibit,FPH1,BRD6125,BRD 6125,FPH 1,FPH-1,Inhibitor;2-(N-(5-chloro-2-Methylphenyl)MethylsulfonaMido)-N-(2,6-difluorophenyl)acetaMide;2-[(5-Chloro-2-methylphenyl)(methylsulfonyl)amino]-N-(2,6-difluorophenyl)-acetamide;Acetamide, 2-[(5-chloro-2-methylphenyl)(methylsulfonyl)amino]-N-(2,6-difluorophenyl)-
- CBNumber:
- CB72729652
- Molecular Formula:
- C16H15ClF2N2O3S
- Molecular Weight:
- 388.82
- MDL Number:
- MFCD04376899
- MOL File:
- 708219-39-0.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319 | |||||||||
| Precautionary statements | P264-P270-P280-P301+P312-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-36/38 | |||||||||
| Safety Statements | 26 | |||||||||
| WGK Germany | 3 | |||||||||
| NFPA 704 |
|
2-(N-(5-chloro-2-Methylphenyl)MethylsulfonaMido)-N-(2,6-difluorophenyl)acetaMide price More Price(20)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0827 | FPH1 ≥98% (HPLC) | 708219-39-0 | 5mg | $118 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML0827 | FPH1 ≥98% (HPLC) | 708219-39-0 | 25mg | $479 | 2024-03-01 | Buy |
| Cayman Chemical | 21804 | BRD6125 ≥98% | 708219-39-0 | 1mg | $49 | 2024-03-01 | Buy |
| Cayman Chemical | 21804 | BRD6125 ≥98% | 708219-39-0 | 5mg | $96 | 2024-03-01 | Buy |
| Cayman Chemical | 21804 | BRD6125 ≥98% | 708219-39-0 | 10mg | $143 | 2024-03-01 | Buy |
2-(N-(5-chloro-2-Methylphenyl)MethylsulfonaMido)-N-(2,6-difluorophenyl)acetaMide Chemical Properties,Uses,Production
Uses
2-(N-(5-Chloro-2-methylphenyl)methylsulfonamido)-N-(2,6-difluorophenyl)acetamide is a small molecule that enhances hepatocyte functions and promotes the differentiation if induced pluripotent stem cell-derived hepatocytes towards a more mature phenotype than what was previously obtainable.
Biological Activity
fph1 is a small molecule that promotes the functional proliferation of primary hepatocytes [1].fph1 belongs to the functional proliferation hits which are screened out by their ability to permit renewable sourcing of functional human hepatocytes. this ability of fph1 is not dependent on the donors of the hepatocytes. it has been found that fph1 was active against the primary human hepatocytes from six cell sources of genetically diverse individuals. besides that, fph1 can affect the hepatocyte functions with promoting albumin secretion during the differentiation of ips cells into iheps. moreover, treatment of fph1 also resulted in the increase of cyp3a4 levels and the decrease of afp secretion [1].
References
[1] shan j, schwartz r e, ross n t, et al. identification of small molecules for human hepatocyte expansion and ips differentiation. nature chemical biology, 2013.
2-(N-(5-chloro-2-Methylphenyl)MethylsulfonaMido)-N-(2,6-difluorophenyl)acetaMide Preparation Products And Raw materials
Raw materials
Preparation Products
2-(N-(5-chloro-2-Methylphenyl)MethylsulfonaMido)-N-(2,6-difluorophenyl)acetaMide Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Meike meditech (Foshan) Co.,Ltd | +86-0757-22239986 +86-18029359586 | sales@mkmeditech.com | China | 1134 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| Shanghai Rechem science Co., Ltd. | 21-31433387 15618786686 | sales@rechemscience.com | China | 2990 | 58 |
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2923 | 55 | |
| Chembest Research Laboratories Limited | 021-20908456 | sales@BioChemBest.com | China | 6011 | 61 |
| Shanghai Yuanding Chem. Sci. & Tech. Co., Ltd. | 21-57721279 | sales@shydchem.com.cn | China | 982 | 56 |
| Acesys Pharmatech | 18860950986 | tangmanman@zenjipharma.com | China | 1735 | 55 |