2,4-(bis-1-ketohexyl)phloroglucinol

CAS No.
3118-34-1
Chemical Name:
2,4-(bis-1-ketohexyl)phloroglucinol
Synonyms
Hyp9;2,4-(bis-1-ketohexyl)phloroglucinol;1,1′-(2,4,6-Trihydroxy-1,3-phenylene)bis-1-hexanone;1-Hexanone, 1,1'-(2,4,6-trihydroxy-1,3-phenylene)bis-
CBNumber:
CB72750355
Molecular Formula:
C18H26O5
Molecular Weight:
322.4
MDL Number:
MFCD16875422
MOL File:
3118-34-1.mol
Last updated:2023-04-23 13:52:06

2,4-(bis-1-ketohexyl)phloroglucinol Properties

Boiling point 464.3±45.0 °C(Predicted)
Density 1.152±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO: >20mg/mL
pka 5.57±0.50(Predicted)
form powder
color white to light yellow

SAFETY

Risk and Safety Statements

WGK Germany  3

2,4-(bis-1-ketohexyl)phloroglucinol price More Price(4)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich H9791 Hyp9 3118-34-1 5mg $134 2024-03-01 Buy
Sigma-Aldrich H9791 Hyp9 3118-34-1 25mg $322.8 2024-03-01 Buy
American Custom Chemicals Corporation CHM0156462 HYP9 95.00% 3118-34-1 5MG $672.1 2021-12-16 Buy
American Custom Chemicals Corporation CHM0156462 HYP9 95.00% 3118-34-1 25MG $928.97 2021-12-16 Buy
Product number Packaging Price Buy
H9791 5mg $134 Buy
H9791 25mg $322.8 Buy
CHM0156462 5MG $672.1 Buy
CHM0156462 25MG $928.97 Buy

2,4-(bis-1-ketohexyl)phloroglucinol Chemical Properties,Uses,Production

Biochem/physiol Actions

Hyperforin is the active ingredient in St. John′s Wort. It is used to treat depression, known to indirectly inhibit reuptake of serotonin and norepinephrine at the synapse, and recently discovered to exert its actions by directly activating TRPC6. TRPC6 is a member of the canonical transient receptor potential (TRPC) family of ion channels. DAG is the endogenous activator of this channel, and Hyperforin is the only known TRPC6-selective activator. Although it is broadly used, Hyperforin is chemically unstable. Efforts to find a stable but pharmacologically similar TRPC6 activator resulted in the discovery of Hyp9, a simplified phloroglucinol derivative. Like Hyperforin, Hyp9 inhibits serotonin reuptake and induces neurite outgrowth. It increases calcium entry into the cell and selectively increases current through TRPC6 channels.

2,4-(bis-1-ketohexyl)phloroglucinol Preparation Products And Raw materials

Raw materials

Preparation Products

2,4-(bis-1-ketohexyl)phloroglucinol Suppliers

Global( 4)Suppliers
Supplier Tel Email Country ProdList Advantage
Sigma-Aldrich 021-61415566 800-8193336 orderCN@merckgroup.com China 51471 80
Suzhou bayaoke Biotechnology Co., Ltd 18626188356 926069669@qq.com China 500 58
Energy Chemical 021-58432009 400-005-6266 marketing@energy-chemical.com China 44941 58
1,1′-(2,4,6-Trihydroxy-1,3-phenylene)bis-1-hexanone 2,4-(bis-1-ketohexyl)phloroglucinol Hyp9 1-Hexanone, 1,1'-(2,4,6-trihydroxy-1,3-phenylene)bis- 3118-34-1