2,3-DIHYDRO-4-BENZOFURANAMINE
- CAS No.
- 61090-37-7
- Chemical Name:
- 2,3-DIHYDRO-4-BENZOFURANAMINE
- Synonyms
- 2,3-dihyro-4-benzofuranamine;4-Amino-2,3-dihydrobenzofuran;2,3-dihydrobenzofuran-4-aMine;2,3-DIHYDRO-4-BENZOFURANAMINE;2,3-Dihydro-4-aminobenzofuran;4-Benzofuranamine, 2,3-dihydro-;2,3-Dihydro-1-benzofuran-4-amine;2,3-Dihydro-1-benzofuran-4-ylamine;5H,6H,7H,7aH-cyclopenta[b]pyran-5-aMine;2,3-dihydrobenzofuran-4-amine hydrochloride
- CBNumber:
- CB7300400
- Molecular Formula:
- C8H9NO
- Molecular Weight:
- 135.16
- MDL Number:
- MFCD06659470
- MOL File:
- 61090-37-7.mol
| Product description | Number | Pack Size | Price |
| 2,3-Dihydrobenzofuran-4-amine | FD42290 | 250mg | $95 |
| 2,3-Dihydrobenzofuran-4-amine | W7338 | 100mg | $104 |
| 2,3-Dihydro-4-benzofuranamine 95% | OR930204 | 250mg | $160 |
| 2,3-Dihydrobenzofuran-4-amine | FD42290 | 500mg | $160 |
| 2,3-Dihydrobenzofuran-4-amine | FD42290 | 50mg | $40 |
| Boiling point | 268.5±29.0 °C(Predicted) |
|---|---|
| Density | 1.208±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C(protect from light) |
| pka | 3.94±0.20(Predicted) |
| Appearance | Off-white to light brown Solid |
| InChI | InChI=1S/C8H9NO/c9-7-2-1-3-8-6(7)4-5-10-8/h1-3H,4-5,9H2 |
| InChIKey | RWPLKRGISDOAAG-UHFFFAOYSA-N |
| SMILES | O1C2=CC=CC(N)=C2CC1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| HS Code | 2932990090 |
2,3-DIHYDRO-4-BENZOFURANAMINE price More Price(23)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth Carbosynth | FD42290 | 2,3-Dihydrobenzofuran-4-amine | 61090-37-7 | 250mg | $95 | 2021-12-16 | Buy |
| AK Scientific | W7338 | 2,3-Dihydrobenzofuran-4-amine | 61090-37-7 | 100mg | $104 | 2021-12-16 | Buy |
| Apolloscientific | OR930204 | 2,3-Dihydro-4-benzofuranamine 95% | 61090-37-7 | 250mg | $160 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FD42290 | 2,3-Dihydrobenzofuran-4-amine | 61090-37-7 | 500mg | $160 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FD42290 | 2,3-Dihydrobenzofuran-4-amine | 61090-37-7 | 50mg | $40 | 2021-12-16 | Buy |
2,3-DIHYDRO-4-BENZOFURANAMINE Chemical Properties,Uses,Production
Synthesis
![N-[2-(2-hydroxyethyl)-3-Methoxyphenyl]-2,2-
diMethylpropanaMide](/CAS/GIF/76093-72-6.gif)
76093-72-6
61090-37-7
Synthesis of 4-amino-2,3-dihydrobenzofuran (1c): compound 1b (4.10 g, 16.3 mmol) was dissolved in 48% aqueous hydrobromic acid solution (20.0 mL) and mixed with thorough stirring. The reaction mixture was heated to reflux at 110°C for 16 hours. Upon completion of the reaction, the mixture was cooled to room temperature, followed by the slow addition of sodium hydroxide pellets in an ice bath at 0°C to adjust the pH to about 9. The reaction mixture was extracted several times with ethyl acetate (50 mL × 4). The organic phases were combined, dried over anhydrous sodium sulfate and filtered. The filtrate was concentrated under reduced pressure to give the crude product. Purification of the crude product by medium pressure column chromatography (Smart Flash EPCLC W-Prep 2XY system, eluent: hexane/ethyl acetate = 1/1) afforded 4-amino-2,3-dihydrobenzofuran (Compound 1c) (1.49 g, 11.0 mmol, 67.7% yield) as a colorless solid. tlc Rf = 0.30 (unfolding agent: Hexane/ethyl acetate = 1/1).1H NMR (400 MHz, CDCl3) δ 6.94 (dd, J = 8.4, 8.4 Hz, 1H), 6.28 (dd, J = 0.4, 7.6 Hz, 1H), 6.23 (dd, J = 0.4, 7.6 Hz, 1H), 4.59 (t, J = 8.4 Hz, 2H), 3.60 ( br s, 2H), 3.02 (t, J = 8.4 Hz, 2H).
References
[1] Patent: EP2881397, 2015, A1. Location in patent: Paragraph 0053; 0058; 0059
[2] Patent: US2016/303089, 2016, A1. Location in patent: Paragraph 0161; 0168; 0169; 0170; 0171
[3] Patent: US2008/318941, 2008, A1. Location in patent: Page/Page column 39
[4] Patent: WO2009/23844, 2009, A2. Location in patent: Page/Page column 127-128
[5] Patent: US2008/200471, 2008, A1. Location in patent: Page/Page column 60; 61-62
2,3-DIHYDRO-4-BENZOFURANAMINE Preparation Products And Raw materials
2,3-DIHYDRO-4-BENZOFURANAMINE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 | info@dakenam.com | China | 13843 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569262 +86-15003564040 | 1056@dideu.com | China | 3982 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30227 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52705 | 58 |
| Changzhou Guiding Bio-Tech. Co.,Ltd. | +86-519-519-86686860 +8618795626222 | ning@guiding-bio.com | China | 299 | 58 |
| Labnetwork lnc. | +86-27-50766799 +8618062016861 | contact@labnetwork.com | China | 19987 | 58 |
| PT CHEM GROUP LIMITED | +86-85511178; | peter68@ptchemgroup.com | China | 35425 | 58 |
