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Scopolamine Hydrobromide Trihydrate

Scopolamine Hydrobromide Trihydrate Structure
Scopolamine Hydrobromide Trihydrate structure
CAS No.
6533-68-2
Chemical Name:
Scopolamine Hydrobromide Trihydrate
Synonyms
screen;tripton;Benzeneacetic acid, .alpha.-(hydroxymethyl)-, (1.alpha.,2.beta.,4.beta.,5.alpha.,7.beta.)-9-methyl-3-oxa-9-azatricyclo3.3.1.02,4non-7-yl ester, hydrobromide, trihydrate, (.alpha.S)-;C17H21NO4BRH3H2O;Scopolamine CRS.;Scopolamine-d3.HBr;Tiotropium Impurity 21;),hydrobromide,trihydrate;East pol base hydrobromide;Scopolamine Hydrobromide RS
CBNumber:
CB7311132
Molecular Formula:
C17H24BrNO5
Molecular Weight:
402.29
MDL Number:
MFCD00150066
MOL File:
6533-68-2.mol
Last updated:2023-11-01 13:52:34
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Scopolamine Hydrobromide Trihydrate Properties

Melting point 197-194 °C
refractive index -25.5 ° (C=5, H2O)
storage temp. Poison room
solubility H2O: soluble50mg/mL
form Crystals or Crystalline Powder
color white to off-white
optical activity [α]25/D 24 to 26°, c = 5 in H2O(lit.)
Merck 14,8406
BRN 6100669
Stability Stable, but air and light sensitive. Incompatible with acids, bases, strong oxidizing agents. Slightly hygroscopic.
LogP 0.760 (est)
CAS DataBase Reference 6533-68-2(CAS DataBase Reference)
FDA UNII 451IFR0GXB
EPA Substance Registry System Scopolamine hydrobromide trihydrate (6533-68-2)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS06
Signal word  Danger
Hazard statements  H300+H310+H330
Precautionary statements  P260-P262-P264-P280-P302+P352+P310-P304+P340+P310
Hazard Codes  T+
Risk Statements  26/27/28
Safety Statements  45-25-1
RIDADR  UN1544 6.1/PG 3
WGK Germany  1
RTECS  YM4550000
HazardClass  6.1
PackingGroup  III
HS Code  29399990

Scopolamine Hydrobromide Trihydrate price More Price(24)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich S0929 Scopolamine hydrobromide meets USP testing specifications 6533-68-2 1g $74.9 2024-03-01 Buy
Sigma-Aldrich PHR1470 Scopolamine Hydrobromide Pharmaceutical Secondary Standard; Certified Reference Material 6533-68-2 500mg $124 2024-03-01 Buy
Sigma-Aldrich S1875 (?)-Scopolamine hydrobromide trihydrate ≥98% (HPLC), powder 6533-68-2 1g $77.4 2024-03-01 Buy
Sigma-Aldrich S1875 (?)-Scopolamine hydrobromide trihydrate ≥98% (HPLC), powder 6533-68-2 5g $287 2024-03-01 Buy
Sigma-Aldrich S1875 (?)-Scopolamine hydrobromide trihydrate ≥98% (HPLC), powder 6533-68-2 25g $975 2024-03-01 Buy
Product number Packaging Price Buy
S0929 1g $74.9 Buy
PHR1470 500mg $124 Buy
S1875 1g $77.4 Buy
S1875 5g $287 Buy
S1875 25g $975 Buy

Scopolamine Hydrobromide Trihydrate Chemical Properties,Uses,Production

Description

Scopolamine hydrobromide is a bronchodilator indicated for the maintenance treatment of chronic obstructive pulmonary disease (COPD), including chronic bronchitis and emphysema, the maintenance treatment of concomitant dyspnea and the prevention of acute exacerbations.

Chemical Properties

white crystalline solid

Uses

Scopolamine is a nasal decongestant and adrenergic agonist that is used to dilate the pupil, reduce eye focusing ability, control saliva and gastric acid production, slow intestinal movements, and prevent vomiting.

Definition

ChEBI: Scopolamine hydrobromide trihydrate is a hydrate that is the trihydrate form of scopolamine hydrobromide. It has a role as a mydriatic agent, a muscarinic antagonist, an anaesthesia adjuvant, an antispasmodic drug and an antiemetic. It contains a scopolamine hydrobromide (anhydrous).

brand name

Isopto Hyoscine (Alcon); Transderm-Scop (Ciba-Geigy).

General Description

White orthorhombic sphenoidal crystals from water. pH of 0.05 molar solution: 5.85.

Air & Water Reactions

Is sensitive to air, light and moisture. Slightly efflorescent in dry air.

Reactivity Profile

SCOPOLAMINE HYDROBROMIDE TRIHYDRATE is incompatible with acids, bases and oxidizing agents. .

Fire Hazard

Flash point data for SCOPOLAMINE HYDROBROMIDE TRIHYDRATE are not available. SCOPOLAMINE HYDROBROMIDE TRIHYDRATE is probably combustible.

Mode of action

Scopolamine Hydrobromide[6533-68-2] is a Belladonna Alkaloid with Anticholinergic Activity. It competitively inhibits muscarinic receptors of the parasympathetic nervous system for acetylcholine and act as a nonselective muscarinic antagonist, producing peripheral anti-muscarinic, central sedative and antiemetic effects. The parasympatholytic scopolamine, structurally very similar to atropine as well, is used in conditions requiring decreased parasympathetic activity. Therefore, scopolamine can inhibit the secretion of saliva and sweat, decrease gastrointestinal secretions and motility, and increase heart rate et al.

References

[1] KLINKENBERGINGE BloklandArjan. The validity of scopolamine as a pharmacological model for cognitive impairment: a review of animal behavioral studies.[J]. Neuroscience and Biobehavioral Reviews, 2010. DOI:10.1016/j.neubiorev.2010.04.001.
[2] CEYHAN T, KARTAL M, ALTUN M L, et al. LC determination of atropine sulfate and scopolamine hydrobromide in pharmaceuticals.[J]. Journal of pharmaceutical and biomedical analysis, 2001, 25 3-4: 399-406. DOI:10.1016/S0731-7085(00)00514-8.
[3] STEENKAMPP A. Fatal Datura poisoning: identification of atropine and scopolamine by high performance liquid chromatography/photodiode array/mass spectrometry.[J]. Forensic science international, 2004. DOI:10.1016/j.forsciint.2004.03.011.
[4] MUHTADI F J, HASSAN M M A. Analytical Profile Of Scopolamine Hydrobromide[C]//Vol. 19. 1990: 477-551. DOI:10.1016/S0099-5428(08)60376-7.

Scopolamine Hydrobromide Trihydrate Preparation Products And Raw materials

Raw materials

ANISODAMINE Hydrogen bromide

Preparation Products

Scopolamine Hydrobromide Trihydrate Suppliers

Global( 178)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Yanxi Chemical Co., Ltd. 		+8617531190177 peter@yan-xi.com China 6011 58
Anhui Zhongda Biotechnology Co., Ltd 		+8619956560829 justine@zhongda-biotech.com China 300 58
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21688 55
Shenzhen Nexconn Pharmatechs Ltd 		+86-755-89396905 +86-15013857715 admin@nexconn.com China 10247 58
Hubei Jusheng Technology Co.,Ltd. 		18871490254 linda@hubeijusheng.com CHINA 28180 58
Xiamen AmoyChem Co., Ltd 		+86-592-6051114 +8618959220845 sales@amoychem.com China 6387 58
Hebei shuoxi biotechnology co. LTD 		+8613081092107 CHINA 968 58
zhangjiagang vinsce bio-pharm. limited. 		86-512-58389969 sales1@swellxin.com CHINA 111 58
WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD 		+8615377521700 wangwendy93@gmail.com China 868 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
Supplier Advantage
Hebei Yanxi Chemical Co., Ltd. 		58
Anhui Zhongda Biotechnology Co., Ltd 		58
Henan Tianfu Chemical Co.,Ltd. 		55
Shenzhen Nexconn Pharmatechs Ltd 		58
Hubei Jusheng Technology Co.,Ltd. 		58
Xiamen AmoyChem Co., Ltd 		58
Hebei shuoxi biotechnology co. LTD 		58
zhangjiagang vinsce bio-pharm. limited. 		58
WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD 		58
TargetMol Chemicals Inc. 		58

View Lastest Price from Scopolamine Hydrobromide Trihydrate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Scopolamine Hydrobromide Trihydrate pictures 2024-03-16 Scopolamine Hydrobromide Trihydrate
6533-68-2
 US $0.00 / KG 100g 98%+ 100kg WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
SCOPOLAMINE HYDROBROMIDE TRIHYDRATE pictures 2023-11-03 SCOPOLAMINE HYDROBROMIDE TRIHYDRATE
6533-68-2
 US $10.00 / g 1g 99% 500tons Anhui Zhongda Biotechnology Co., Ltd
SCOPOLAMINE HYDROBROMIDE TRIHYDRATE pictures 2023-10-21 SCOPOLAMINE HYDROBROMIDE TRIHYDRATE
6533-68-2
 US $50.00 / kg 1kg 0.99 10000 Hebei Yanxi Chemical Co., Ltd.

Scopolamine Hydrobromide Trihydrate Spectrum

SCOPOLAMINE HYDROBROMIDE TRIHYDRATE(6533-68-2)1HNMRSCOPOLAMINE HYDROBROMIDE TRIHYDRATE(6533-68-2)RamanSCOPOLAMINE HYDROBROMIDE TRIHYDRATE(6533-68-2)FT-IR

6533-68-2(Scopolamine Hydrobromide Trihydrate)Related Search:

Scopolamine Methscopolamine bromide Scopolamine butylbromide SCOPOLAMINE N-OXIDE HYDROBROMIDE HYOSCINE N BUTYL BROMIDE BP
Scopolamine hydrobromide Scopine HYOSCINE HYDROCHLORIDE ATROPINE-D3 98 ATOM % D Scopolamine Hydrobromide Trihydrate
ANISODAMINE HYDROBROMIDE SCOPOLAMINE-D3 HBR 3H2O (N-METHYL-D3) HYOSCYAMINE HYDROBROMIDE

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Hyoscine hydrobromide, Scopine tropate Scopolamine-d3.HBr (-)-Scopolamine hydrobromide trihydrate Hydrobromide Trihydrate ScopolaMine HBr (Hyoscine HBr) Benzeneacetic acid, a-(hydroxyMethyl)-, (1a,2b,4b,5a,7b)-9-Methyl-3-oxa-9-azatricyclo[3.3.1.02,4]non-7-ylester, hydrobroMide, hydrate (1:1:3), (aS)- Scopolamine Hydrobromide (250 mg) ScopolaMine-d3.HBr (Hyoscine-d3 HBr) SCOPOLAMINE HYDROBROMIDE TRIHYDRATE ),hydrobromide,trihydrate ATROSCINE HYDROBROMIDE TRIHYDRATE HYOSCINE HYDROBROMIDE TRIHYDRATE SCOPOLAMINE HYDROBROMIDE USP ScopolamineHydrobromideTrihydrate99% Scopolaminhydrobromidetrihydrate (-)-SCOPOLAMINE HYDROBROMIDE TRIHYDRATE SCOPOLAMINEHYDROBROMIDE,TRIHYDRATE,USP (-)-Scopolamine trihydrate hydrobromide, Hyoscine hydrobromide, Scopine tropate (-)-Scopolamine trihydrate hydrobromide Scopolamine hydrobromide trihydrate, 99%, from Datura metel L. C17H21NO4BRH3H2O (1S,2R,4S,5S)-9-methyl-3-oxa-9-azatricyclo[3.3.1.0~2,4~]non-7-yl 3-hydroxy-2-phenylpropanoate hydrobromide trihydrate 9-methyl-3-oxa-9-azatricyclo[3.3.1.0~2,4~]non-7-yl 3-hydroxy-2-phenylpropanoate (1S,2R,4S,5S)-9-methyl-3-oxa-9-azatricyclo[3.3.1.0~2,4~]non-7-yl 3-hydroxy-2-phenylpropanoate hydrobromid (1R,5S)-9-methyl-3-oxa-9-azatricyclo[3.3.1.0~2,4~]non-7-yl (2S)-3-hydroxy-2-phenylpropanoate hydrobromide trihydrate (1S,2R,4S,5S)-9-methyl-3-oxa-9-azatricyclo[3.3.1.0~2,4~]non-7-yl (2S)-3-hydroxy-2-phenylpropanoatato hydrobromide trihydrate (-)-Scopolamine hydrobromide trihydrate Hydrobromide Trihydrate, ≥99% Scopolamine Hydrobromide RS Hyoscine hydrobromide trihydrate【(-)-Scopolamine hydrobromide trihydrate】 (-)-ScopolaminehydrobromidetrihydrateHydrobromideTrihydrate East pol base hydrobromide (1R,2R,4S,5S,7R)-9-methyl-3-oxa-9-azatricyclo[3.3 .1.0,2,4]nonan-7-yl (2S)-3-hydroxy-2-phenylpropanoate trihydrate hydrobromide (1R,2R,4S,5S,7s)-9-methyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-7-yl (S)-3-hydroxy-2-phenylpropanoate hydrobromide trihydrate Scopolamine Hydrobromide TrihydrateQ: What is Scopolamine Hydrobromide Trihydrate Q: What is the CAS Number of Scopolamine Hydrobromide Trihydrate Q: What is the storage condition of Scopolamine Hydrobromide Trihydrate Q: What are the applications of Scopolamine Hydrobromide Trihydrate Benzeneacetic acid, a-(hydroxymethyl)-,(1a,2b,4b,5a,7b)-9-methyl-3-oxa-9-azatricyclo[3.3.1.02,4]non-7-yl ester,hydrobromide, trihydrate, (aS)- hydrogen (1S,2R,4S,5S)-9-methyl-3-oxa-9-azatricyclo[3.3.1.02,]nonan-7-yl (2S)-3-hydroxy-2-phenylpropanoate trihydrate bromide Scopolamine Hydrobromide (1610001) screen tripton Benzeneacetic acid, .alpha.-(hydroxymethyl)-, (1.alpha.,2.beta.,4.beta.,5.alpha.,7.beta.)-9-methyl-3-oxa-9-azatricyclo3.3.1.02,4non-7-yl ester, hydrobromide, trihydrate, (.alpha.S)- (1S,2R,4S,5S,7R)-9-methyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-7-yl (S)-3-hydroxy-2-phenylpropanoate hydrobromide trihydrate Atropine EP Impurity F as Hydrobromide Trihydrate Hyoscyamine Sulfate EP Impurity D as Hydrobromide Trihydrate Hyoscyamine Sulfate EP Impurity D Hyoscine Butylbromide EP Impurity A as Hydrobromide Trihydrate Atropine Impurity F (Hyoscine) Scopolamine CRS. Tiotropium Impurity 21 Hyoscine Hydrobromide / Scopolamine Hydrobromide Trihydrate 6533-68-2 65333-68-2 C17H22BrNO43H2O C17H18D3NO4HBr C17H28BrNO7 C17H21NO4HBr3H2O C17H22BrNO4x3H2O Alkaloids Tropane Alkaloids Inhibitors