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Scopolamine hydrobromide

Scopolamine hydrobromide
Scopolamine hydrobromide structure
CAS No.
114-49-8
Chemical Name:
Scopolamine hydrobromide
Synonyms
hysco;Hyosol;kwells;scopos;sereen;scopamin;triptone;HYOSCINE;euscopol;Tranaxine
CBNumber:
CB9363236
Molecular Formula:
C17H21NO4.BrH
Formula Weight:
384.26
MOL File:
114-49-8.mol

Scopolamine hydrobromide Properties

Melting point:
195-199 °C (dry matter)(lit.)
alpha 
D25 -24 to -26° (c = 5, calculated on anhydrous basis)
storage temp. 
Store at RT
solubility 
H2O: 50 mg/mL
form 
powder
color 
white to off-white
CAS DataBase Reference
114-49-8(CAS DataBase Reference)
FDA 21 CFR
310.545
FDA UNII
451IFR0GXB
EPA Substance Registry System
Scopolamine hydrobromide (114-49-8)
SAFETY
  • Risk and Safety Statements
Hazard Codes  Xn
Risk Statements  22
Safety Statements  36
RIDADR  UN 1544 6.1/PG 1
WGK Germany  3
RTECS  YM4550000
3-8
HS Code  2939800000
Toxicity LD50 in rats (mg/kg): 3800 s.c. (Stockhaus, Wick)

Scopolamine hydrobromide price More Price(7)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich S0929 Scopolamine hydrobromide meets USP testing specifications 114-49-8 1 g $60.4 2021-03-22 Buy
Sigma-Aldrich PHR1470 Scopolamine Hydrobromide Pharmaceutical Secondary Standard; Certified Reference Material 114-49-8 500 mg $92.7 2021-03-22 Buy
Sigma-Aldrich S0929 Scopolamine hydrobromide meets USP testing specifications 114-49-8 5 g $230 2021-03-22 Buy
Sigma-Aldrich 1610001 Scopolamine hydrobromide United States Pharmacopeia (USP) Reference Standard 114-49-8 500 mg $366 2021-03-22 Buy
Sigma-Aldrich S0929 Scopolamine hydrobromide meets USP testing specifications 114-49-8 25 g $951 2021-03-22 Buy

Scopolamine hydrobromide Chemical Properties,Uses,Production

Chemical Properties

Off-White Solid

Uses

An acetylcholine antagonist. Used in treatment of motion sickness; antiemetic; antispasmodic; mydriatic; preanesthetic medicant

Definition

ChEBI: A hydrobromide that is obtained by reaction of scopolamine with hydrogen bromide.

brand name

Isopto Hyoscine (Alcon); Transderm-Scop (Ciba-Geigy).

General Description

Scopolamine hydrobromide(hyoscine hydrobromide) occurs as white orcolorless crystals or as a white, granular powder. It is odorlessand tends to effloresce in dry air. It is freely soluble inwater (1:1.5), soluble in alcohol (1:20), only slightly solublein chloroform, and insoluble in ether.
Scopolamine is a competitive blocking agent of theparasympathetic nervous system as is atropine, but it differsmarkedly from atropine in its action on the higher nervecenters. Both drugs readily cross the blood-brain barrierand, even at therapeutic doses, cause confusion, particularlyin the elderly.

General Description

Colorless crystals or white powder or solid. Has no odor. pH (of 5% solution): 4-5.5. Slightly efflorescent in dry air. Bitter, acrid taste.

Air & Water Reactions

Sensitive to air, light and moisture. Water soluble.

Reactivity Profile

Scopolamine hydrobromide is incompatible with acids, bases and oxidizing agents. .

Fire Hazard

Flash point data for Scopolamine hydrobromide are not available; however, Scopolamine hydrobromide is probably combustible.

Biological Activity

Non-selective muscarinic antagonist. Widely used clinically to treat motion sickness.

Clinical Use

A sufficiently large dose of scopolamine will cause an individualto sink into a restful, dreamless sleep for about8 hours, followed by a period of approximately the samelength in which the patient is in a semiconscious state.During this time, the patient does not remember events thattake place. When scopolamine is administered with morphine,this temporary amnesia is termed twilight sleep.

Purification Methods

The hydrobromide is recrystallised from Me2CO, H2O or EtOH/Et2O and dried. It is soluble in H2O (60%) and EtOH (5%) but insoluble in Et2O and slightly in CHCl3. The hydrochloride has m 300o (from Me2CO). The free base is a viscous liquid which forms a crystalline hydrate with m 59o and [] D 20 -28o (c 2.7, H2O). It hydrolyses in dilute acid or base. [Meinwald J Chem Soc 712 1953, Fodor Tetrahedron 1 86 1957, Beilstein 6 III 4185.]

Scopolamine hydrobromide Preparation Products And Raw materials

Raw materials

Preparation Products


Scopolamine hydrobromide Suppliers

Global( 406)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan DaKen Chemical CO.,LTD.
+86-371-66670886
info@dakenchem.com China 20918 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22607 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29954 58
SHANDONG ZHI SHANG CHEMICAL CO.LTD
+86 18953170293
+86 0531-67809011 sales@sdzschem.com CHINA 2941 58
Chengdu Biopurify Phytochemicals Ltd.
18482058008 18080483897
maggie@biopurify.com CHINA 2712 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 linda@hubeijusheng.com CHINA 28229 58
hdzhl biotechnology co., ltd
86-13032617415
sales@luchibiology.com CHINA 1275 58
Shandong chuangyingchemical Co., Ltd.
18853181302
sale@chuangyingchem.com CHINA 5917 58
Chongqing Chemdad Co., Ltd
+86-13650506873
sales@chemdad.com CHINA 37282 58
Shanghai Standard Technology Co., Ltd.
18502101150
+86-21-57127007-6606 ft-sales@nature-standard.com CHINA 1923 58

View Lastest Price from Scopolamine hydrobromide manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-11-26 Scopolamine hydrobromide
114-49-8
US $10.00 / KG 1KG 99% 10tons Xingtai Haoxun Import and Export Trade Co., Ltd.
2021-11-15 Scopolamine hydrobromide
114-49-8
US $82.00 / KG 10KG 99.9% 100tons Hebei Yirun Sega Biological Technology Co. Ltd
2021-11-08 Scopolamine hydrobromide
114-49-8
US $10.00 / KG 1KG 99% 100MT/Month Wuhan wingroup Pharmaceutical Co., Ltd

Scopolamine hydrobromide Spectrum


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