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Scopolamine hydrobromide

Scopolamine hydrobromide
Scopolamine hydrobromide
CAS No.
114-49-8
Chemical Name:
Scopolamine hydrobromide
Synonyms
hysco;Hyosol;kwells;scopos;sereen;euscopol;scopamin;triptone;HYOSCINE;beldavrin
CBNumber:
CB9363236
Molecular Formula:
C17H22BrNO4
Formula Weight:
384.26
MOL File:
114-49-8.mol

Scopolamine hydrobromide Properties

Melting point:
195-199 °C (dry matter)(lit.)
alpha 
D25 -24 to -26° (c = 5, calculated on anhydrous basis)
storage temp. 
Store at RT
solubility 
H2O: 50 mg/mL
form 
powder
color 
white to off-white
CAS DataBase Reference
114-49-8(CAS DataBase Reference)
EPA Substance Registry System
Benzeneacetic acid, .alpha.-(hydroxymethyl)-, (1.alpha.,2.beta.,4.beta., 5.alpha.,7.beta.)-9-methyl- 3-oxa-9-azatricyclo[3.3.1. 02,4]non-7-yl ester, hydrobromide, (.alpha.S)-(114-49-8)

SAFETY

Hazard Codes  Xn
Risk Statements  22
Safety Statements  36
RIDADR  UN 1544 6.1/PG 1
WGK Germany  3
RTECS  YM4550000
3-8
Toxicity LD50 in rats (mg/kg): 3800 s.c. (Stockhaus, Wick)

Scopolamine hydrobromide price More Price(2)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 14108 Scopolamine (hydrobromide) ≥95% 114-49-8 1mg $65 2018-11-19 Buy
Cayman Chemical 14108 Scopolamine (hydrobromide) ≥95% 114-49-8 5mg $292 2018-11-19 Buy

Scopolamine hydrobromide Chemical Properties,Uses,Production

Chemical Properties

Off-White Solid

Uses

An acetylcholine antagonist. Used in treatment of motion sickness; antiemetic; antispasmodic; mydriatic; preanesthetic medicant

Definition

ChEBI: A hydrobromide that is obtained by reaction of scopolamine with hydrogen bromide.

brand name

Isopto Hyoscine (Alcon); Transderm-Scop (Ciba-Geigy).

General Description

Colorless crystals or white powder or solid. Has no odor. pH (of 5% solution): 4-5.5. Slightly efflorescent in dry air. Bitter, acrid taste.

Air & Water Reactions

Sensitive to air, light and moisture. Water soluble.

Reactivity Profile

Scopolamine hydrobromide is incompatible with acids, bases and oxidizing agents. .

Fire Hazard

Flash point data for Scopolamine hydrobromide are not available; however, Scopolamine hydrobromide is probably combustible.

Biological Activity

Non-selective muscarinic antagonist. Widely used clinically to treat motion sickness.

Purification Methods

The hydrobromide is recrystallised from Me2CO, H2O or EtOH/Et2O and dried. It is soluble in H2O (60%) and EtOH (5%) but insoluble in Et2O and slightly in CHCl3. The hydrochloride has m 300o (from Me2CO). The free base is a viscous liquid which forms a crystalline hydrate with m 59o and [] D 20 -28o (c 2.7, H2O). It hydrolyses in dilute acid or base. [Meinwald J Chem Soc 712 1953, Fodor Tetrahedron 1 86 1957, Beilstein 6 III 4185.]

Scopolamine hydrobromide Preparation Products And Raw materials

Raw materials

Preparation Products


Scopolamine hydrobromide Suppliers

Global( 249)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Zhenfei Industrial Co. Ltd.
+86 15318988277
sales@zhenfeichem.com CHINA 75 58
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3217 55
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 22046 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20786 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32651 55
Hubei Jusheng Technology Co.,Ltd.
86-155-27864001
peter@hubeijusheng.com CHINA 18004 58
Chengdu Biopurify Phytochemicals Ltd.
18080483897
maggie@biopurify.com CHINA 2238 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 19990 58
3B Pharmachem (Wuhan) International Co.,Ltd. 86-21-50328103 * 801、802、803、804 Mobile:18930552037
86-21-50328109 3bsc@sina.com China 15926 69
future industrial shanghai co., ltd 400-0066-400;021-60496031
021-55660885 sales@jonln.com China 2042 65

View Lastest Price from Scopolamine hydrobromide manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-11-08 Scopolamine Hydrobromide Powder
114-49-8
US $8000.00 / KG 1G 99% 20KG/Month Zhenfei Industrial Co. Ltd.
2018-08-20 Scopolamine hydrobromide
114-49-8
US $1.00 / KG 1G 98% 100KG career henan chemical co

Scopolamine hydrobromide Spectrum


114-49-8(Scopolamine hydrobromide)Related Search:


  • 5-alpha-h-tropan-3-alpha-ol,6-beta,7-beta-epoxy-1-alpha-(-)-tropate(ester
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  • beldavrin
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  • (aS)-a-(Hydroxymethyl)benzeneacetic Acid (1a,2,4,5a,7)-9-(Methyl-d3)-3-oxa-9-azatricyclo[3.3.1.02,4]non-7-yl Ester
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  • (alpha,S)-alpha-(Hydroxymethyl)benzeneacetic acid (1alpha,2beta,4beta,5alpha,7beta)-9-methyl-3-oxa-9-azatricyclo[3.3.1.0(2.4)]non-7-yl ester hydrobromide
  • hydroscinehydrobromide
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  • (αS)-α-(hydroxymethyl)-benzeneacetic acid-(1α,2β,4β,5α,7β)-9-methyl-3-oxa-9-azatricyclo[3.3.1.02,4]non-7-yl ester
  • (α,S)-α-(Hydroxymethyl)benzeneaceticacid(1α,2β,4β,5α,7β)-9-methyl-3-oxa-9-azatricyclo[3.3.1.02,4]non-7-ylesterhydrobromide
  • ()-Scopolamine hydrobromide trihydrate,Hyoscine hydrobromide, Scopine tropate
  • Hyoscine HydrobroMide Trihydrate, (1α,2β,4β,5α,7β)-9-Methyl-3-oxa-9-azatricyclo[3.3.1.02,4]non-7-yl Ester HydrobroMide Trihydrate
  • SCOPOLAMINE HBR
  • (-)-SCOPOLAMINE HYDROBROMIDE
  • SCOPOLAMINE HYDROBROMIDE
  • SCOPOLOAMINE HYDROBROMIDE
  • SCOPINE TROPATE HYDROBROMIDE
  • (-)-scopolaminebromide
  • ),hydrobromide
  • scopolamine hydrobromide (anhydrous)
  • (2S,3S,4S,5S)-2,5-bis(hydroxymethyl)pyrrolidine-3,4-diol
  • Scopolamine hydrobromide, 98%, from Datura metel L.
  • Scopolamine Hydrobromide Powder
  • Benzeneacetic acid, a-(hydroxyMethyl)-, (1a,2b,4b,5a,7b)-9-Methyl-3-oxa-9-azatricyclo[3.3.1.02,4]non-7-ylester, hydrobroMide (1:1), (aS)-
  • ScopolaMine-d3 HBr 3H2O
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  • ScopolaMine HBr Trihydrate
  • (?)-Scopolamine hydrobromide hydrate
  • (1S,2R)-9-Methyl-3-oxa-9- azatricyclo[3.3.1.02,4]nonan-7-yl (2S)-3-hydroxy-2-phenylpropanoate trihydrate hydrobromide
  • (1S,2R)-9-Methyl-3-oxa-9- azatricyclo[3.3.1.0^{2,4}]nonan-7-yl- (2S)-3-hydroxy-2-phenylpropano
  • .alpha.-(hydroxymethyl)-,9-methyl-3-oxa-9-azatricyclo[3.3.1.02,4]non-7-ylester,hydrobromide,[7(Benzeneaceticacid
  • 02,4]non-7-ylester,hydrobromide,[7(s)-(1alpha,2beta,4beta,5alpha,7beta)
  • hyoscyinehydrobromide
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  • l-hyoscinehydrobromide
  • scopamin
  • scopolaminebromide
  • scopolaminiumbromide
  • scopolammoniumbromide
  • scopos
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  • triptone
  • ATROSCINE HYDROBROMIDE
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  • HYOSCINE HBR
  • HYOSCINE HYDROBROMIDE
  • HYOSCINE
  • (-)-SCOPOLAMINE HYDROBROMIDE CHOLINERGIC RECEPTOR
  • SCOPOLAMINE HYDROBROMIDE, USP STANDARD
  • Scopolamine hydrobromide, 99.0%
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