TY-52156
- CAS No.
- 934369-14-9
- Chemical Name:
- TY-52156
- Synonyms
- TY-52156;TY52156;TY 52156;TY-52156, 10 mM in DMSO;S1P3 Receptor Antagonist, TY-52156;N,N'-bis(4-Chlorophenyl)-3,3-dimethyl-2-oxobutanimidhydrazide;N'-(4-chloroanilino)-N-(4-chlorophenyl)-3,3-dimethyl-2-oxo-butanamidine;N-(4-chlorophenyl)-N'-(4-chlorophenylamino)-3,3-dimethyl-2-oxobutanamidine;N-(4-Chlorophenyl)-3,3-dimethyl-2-oxobutanimidic 2-(4-chlorophenyl) hydrazide;N'-(4-chlorophenyl)-N-[(4-chlorophenyl)amino]-3,3-dimethyl-2-oxobutanimidamide;Inhibitor,LPL Receptor,TY-52156,inhibit,Lysophospholipid Receptor,TY 52156,TY52156
- CBNumber:
- CB73122351
- Molecular Formula:
- C18H19Cl2N3O
- Molecular Weight:
- 364.27
- MDL Number:
- MFCD30182278
- MOL File:
- 934369-14-9.mol
| Melting point | 90-91 °C |
|---|---|
| Boiling point | 62-69 °C(Press: 20 Torr) |
| Density | 1.22±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C(protect from light) |
| solubility | ≥92.8 mg/mL in DMSO; ≥94.6 mg/mL in EtOH; insoluble in H2O |
| form | crystalline solid |
| pka | 0.99±0.50(Predicted) |
| color | Light yellow to yellow |
| UNSPSC Code | 41116158 |
| NACRES | NA.77 |
TY-52156 price More Price(30)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML2499 | TY-52156 ≥98% (HPLC) | 934369-14-9 | 5mg | $115 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML2499 | TY-52156 ≥98% (HPLC) | 934369-14-9 | 25mg | $462 | 2024-03-01 | Buy |
| Cayman Chemical | 19119 | TY 52156 ≥98% | 934369-14-9 | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 19119 | TY 52156 ≥98% | 934369-14-9 | 5mg | $139 | 2024-03-01 | Buy |
| Cayman Chemical | 19119 | TY 52156 ≥98% | 934369-14-9 | 10mg | $184 | 2024-03-01 | Buy |
TY-52156 Chemical Properties,Uses,Production
Uses
TY 52156 is a sphingosine-1-phosphate receptor subtype 3 (S1PR3) antagonist, which is used for the treatment of lung cancer.
Definition
ChEBI: TY 52156 is an imidohydrazide resulting from the formal condensation of the hydrazide carbonyl group of N'-(p-chlorophenyl)-3,3-dimethyl-2-oxobutanehydrazide with the amino group of p-chloroaniline. A potent and selective antagonist of sphingosine-1-phosphate receptor 3 (S1PR3). It has a role as a sphingosine-1-phosphate receptor 3 antagonist. It is a member of monochlorobenzenes and an imidohydrazide.
Biological Activity
ty 52156 (1-(4-chlorophenylhydrazono)-1-(4-chlorophenylamino)-3,3-dimethyl-2-butanone) is a novel s1p3 receptor antagonist [1].sphingosine 1-phosphate (s1p) is a bioactive lysophospholipid mediator mainly released from activated platelets and implicated in many biological responses, such as angiogenesis, vascular development, and cardiovascular function [1].
in vitro
ty-52156 preferentially inhibited the s1p-induced increase in [ca2+]i in s1p3-cho cells. ty-52156 competitively inhibited the dose-dependent [ca2+]i increase elicited by s1p in s1p3-cho with the ki value of ～110 nm for s1p3 receptor. ty-52156 showed submicromolar potency and a high degree of selectivity for s1p3 receptor. ty-52156 (10 μm) inhihbited 24 gpcrs and three ion channels by 〈 30%. s1p dose-dependently decreased cf (coronary flow) in perfused rat heart. s1p dose-dependently induced vasoconstriction in isolated canine cerebral arteries. in hcasmcs, ty-52156 inhibited s1p-induced rho activation.
in vivo
in sd rats, oral bioavailability of ty-52156 was ～70.9%. in rats, pretreatment with ty-52156 significantly attenuated fty-720-induced bradycardia, a broad agonist of s1p receptors. pretreatment with ty-52156 prevented the fty-720-p-induced increase in [ca2+]i in a dose-dependent manner.
storage
Store at -20°C
References
[1] murakami a, takasugi h, ohnuma s, et al. sphingosine 1-phosphate (s1p) regulates vascular contraction via s1p3 receptor: investigation based on a new s1p3 receptor antagonist[j]. molecular pharmacology, 2010, 77(4): 704-713.
TY-52156 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| TargetMol Chemicals Inc. | +17819995354 | marketing@targetmol.com | United States | 32281 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30230 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| ROSEWA HOLDING GROUP CO.,LIMITED | +86-023-62871537 | sales@rosewachem.com | China | 2828 | 58 |
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4861 | 58 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4621 | 55 | |
| Tcichem, Inc. | 13918644899 | tianchong009@hotmail.com | China | 1817 | 55 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9803 | 58 |
