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Amgen IRE1α Inhibitor

Amgen IRE1α Inhibitor Structure
Amgen IRE1α Inhibitor structure
CAS No.
1630086-20-2
Chemical Name:
Amgen IRE1α Inhibitor
Synonyms
Kira8;Kira8 ，E2652;KIRA8 (AMG-18);IRE-1 INHIBITOR;Kira8, 10 mM in DMSO;Amgen IRE1α Inhibitor;Amgen IRE1a Inhibitor;Amgen IRE1± Inhibitor;Inositol requiring enzyme 1,inhibit,AMG18,AMG 18,Kira 8,Kira8,Inhibitor,IRE1,Kira-8;(S)-2-Chloro-N-[6-methyl-5-[[3-[2-(3-piperidylamino)-4-pyrimidinyl]-2-pyridyl]oxy]-1-naphthyl]benzenesulfonamide
CBNumber:
CB73123772
Molecular Formula:
C31H29ClN6O3S
Molecular Weight:
601.12
MDL Number:
MFCD28404657
MOL File:
1630086-20-2.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-27 17:00:41
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Amgen IRE1α Inhibitor Properties

Boiling point 812.6±75.0 °C(Predicted)
Density 1.383±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility Water:30.0(Max Conc. mg/mL);49.91(Max Conc. mM)
pka 7.66±0.30(Predicted)
form Solid
color Light yellow to yellow
InChIKey XMWUCMFVDXDRDE-NRFANRHFSA-N
SMILES [S](=O)(=O)(Nc2c3c(c(c(cc3)C)Oc4ncccc4c5nc(ncc5)N[C@@H]6CNCCC6)ccc2)c1c(cccc1)Cl
UNSPSC Code 12352200
NACRES NA.77

SAFETY

Risk and Safety Statements

WGK Germany  WGK 3
Storage Class 11 - Combustible Solids

Amgen IRE1α Inhibitor price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich VBP00322 (S)-2-chloro-N-(6-methyl-5-((3-(2-(piperidin-3-ylamino)pyrimidin-4-yl)pyridin-2-yl)oxy)naphthalen-1-yl)benzenesulfonamide AldrichCPR 10 mg $1510 2026-04-30 Buy
Biosynth FQC08620 Amgen IRE1± Inhibitor 1630086-20-2 10mg $851.7 2026-06-04 Buy
Biosynth FQC08620 Amgen IRE1± Inhibitor 1630086-20-2 25mg $1388.5 2026-06-04 Buy
Biosynth FQC08620 Amgen IRE1± Inhibitor 1630086-20-2 50mg $2221.5 2026-06-04 Buy
ChemScene CS-0084229 Kira8 98.90% 1630086-20-2 1mg $119 2026-06-04 Buy
Product number Packaging Price Buy
VBP00322 10 mg $1510 Buy
FQC08620 10mg $851.7 Buy
FQC08620 25mg $1388.5 Buy
FQC08620 50mg $2221.5 Buy
CS-0084229 1mg $119 Buy

Amgen IRE1α Inhibitor Chemical Properties, Uses, Production

Uses

Amgen IRE1α Inhibitor is an inhibitor of IRE1α. IRE1α is a sensor of unfolded protein accumulation that triggers the unfolded protein response.

Biological Activity

KIRA8 is an ATP-competitive, potent and selective IRE1α kinase inhibitor (IRE1α/β Ki = 2/120 nM) th at attenuates IRE1α endonuclease activity (IRE1α/β IC50 = 5/55 nM) with good kinome selectivity. KIRA8 inhibits thapsigargin-induced UPR (IC50 = 99 nM; HT1080 XBP1-Luc cells) and shows therapeutic efficacy in murine models of type 1 diabetes (T1D), pulmonary fibrosis, multiple myeloma (MM), and pancreatic neuroendocrine tumors (PanNET) in vivo (30-50 mg/kg/day i.p.).

in vivo

Male Ins2+/Akita mice are injected i.p. with KIRA8 (50 mg/kg; daily; for 35 days), significant reduction of hyperglycemia become apparent over several weeks[1].
One week treatment of pre-diabetic NODs mice with Kira8 (50 mg/kg; i.p.; once a day) leads to significant reductions in islet XBP1 splicing and TXNIP mRNAs, and preserves Ins1/Ins2, BiP and MANF mRNAs[1].

Animal Model:Male Ins2+/Akita mice[1]
Dosage:50 mg/kg
Administration:Injected i.p.; daily; for 35 days
Result:Significant reduction of hyperglycemia became apparent over several weeks.

Amgen IRE1α Inhibitor Preparation Products And Raw materials

Raw materials

Preparation Products

Amgen IRE1α Inhibitor Suppliers

Global Suppliers ( 56)
Supplier Tel Email Country ProdList Advantage
ShangHai Caerulum Pharma Discovery Co., Ltd. 18149758185 18149758185 sales-cpd@caerulumpharma.com China 3493 58
Sigma-Aldrich 021-61415566 800-8193336 orderCN@merckgroup.com China 51389 80
Shanghai YuanYe Biotechnology Co., Ltd. 15026964105 2881489226@qq.com China 89667 60
Chengdu Saint - Kay Biotechnology Co., Ltd. 028-85157043 15882256948 676046971@qq.com China 4183 58
TargetMol Chemicals Inc. +1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
InvivoChem +1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6378 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11123 58
Shanghai hongqu biomedical technology co. LTD 88888888888 hongquchem@qq.com China 5123 58
Energy Chemical 021-58432009 400-005-6266 marketing@energy-chemical.com China 44871 58
Nantong Hi-Future Biotechnology Co., Ltd +86-0513; 18051384581 sales@chemhifuture.com China 3075 58
Supplier Advantage
ShangHai Caerulum Pharma Discovery Co., Ltd. 58
Sigma-Aldrich 80
Shanghai YuanYe Biotechnology Co., Ltd. 60
Chengdu Saint - Kay Biotechnology Co., Ltd. 58
TargetMol Chemicals Inc. 58
InvivoChem 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
Shanghai hongqu biomedical technology co. LTD 58
Energy Chemical 58
Nantong Hi-Future Biotechnology Co., Ltd 58

View Latest Price from Amgen IRE1α Inhibitor manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Kira8 pictures 2026-07-27 Kira8
1630086-20-2
 $89.00-322.00 99.52% 10g TargetMol Chemicals Inc.
Kira8 pictures 2026-07-27 Kira8
1630086-20-2
 $89.00-322.00 99.52% 10g TargetMol Chemicals Inc.
  • Kira8 pictures
  • Kira8
    1630086-20-2
  • $89.00-322.00
  • 99.52%
  • TargetMol Chemicals Inc.
  • Kira8 pictures
  • Kira8
    1630086-20-2
  • $89.00-322.00
  • 99.52%
  • TargetMol Chemicals Inc.

Amgen IRE1α Inhibitor Spectrum

Amgen IRE1α Inhibitor(1630086-20-2)1HNMR

1630086-20-2 (Amgen IRE1α Inhibitor) Related Search:

4-Amino-5-cyano-7-(beta-D-ribofuranosyl)pyrrolo[2,3-d]pyrimidine KIRA6 Anti-Aging Compound Library Imidazo[1,2-b]pyridazin-8-amine, 6-chloro-3-[6-fluoro-2-(phenylamino)-1H-benzimidazol-5-yl]-N-[(1-methyl-4-piperidinyl)methyl]- 7-hydroxy-4-Methyl-2-oxo-2H-1-Benzopyran-8-carboxaldehyde
Tauroursodeoxycholate dihydrate

1of2

Amgen IRE1α Inhibitor Kira8 IRE-1 INHIBITOR KIRA8 (AMG-18) Benzenesulfonamide, 2-chloro-N-[6-methyl-5-[[3-[2-[(3S)-3-piperidinylamino]-4-pyrimidinyl]-2-pyridinyl]oxy]-1-naphthalenyl]- (S)-2-Chloro-N-(6-methyl-5-((3-(2-(piperidin-3-ylamino)pyrimidin-4-yl)pyridin-2-yl)oxy)naphthalen-1-yl)benzenesulfonamide Amgen IRE1a Inhibitor Inositol requiring enzyme 1,inhibit,AMG18,AMG 18,Kira 8,Kira8,Inhibitor,IRE1,Kira-8 (S)-2-Chloro-N-[6-methyl-5-[[3-[2-(3-piperidylamino)-4-pyrimidinyl]-2-pyridyl]oxy]-1-naphthyl]benzenesulfonamide Kira8, 10 mM in DMSO Amgen IRE1± Inhibitor Kira8 ，E2652 1630086-20-2 C31H29ClN6O3S