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HJC0197

HJC0197 structure

CAS No.: 1383539-73-8

Chemical Name:: HJC0197

Synonyms: HJC0197;HJC 0197 (HJC0197);6-Cyclopentyl-2-((2,5-dimethylbenzyl)thio)-4-oxo-1,4-dihydropyrimidine-5-carbonitrile;5-Pyrimidinecarbonitrile, 4-cyclopentyl-2-[[(2,5-dimethylphenyl)methyl]thio]-1,6-dihydro-6-oxo-;HJC0197,cAMP-signaling,activation,GEF,cellular,Ras,inhibit,HJC-0197,HJC 0197,phosphorylation,processes,Inhibitor

CBNumber:: CB73152628

Molecular Formula:: C19H21N3OS

Molecular Weight:: 339.45

MDL Number:: MFCD27966183

MOL File:: 1383539-73-8.mol

Last updated:2023-09-20 16:43:00

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HJC0197 Properties

solubility	DMF: 10 mg/ml; DMF:PBS(pH7.2) (1:2): 0.2 mg/ml; DMSO: 5 mg/ml
form	A crystalline solid

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H315-H319-H335

Precautionary statements

P280-P305+P351+P338

NFPA 704

	0
2		0

HJC0197 price More Price(9)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	19092	HJC0197 ≥98%	1383539-73-8	1mg	$37	2024-03-01	Buy
Cayman Chemical	19092	HJC0197 ≥98%	1383539-73-8	5mg	$169	2024-03-01	Buy
Cayman Chemical	19092	HJC0197 ≥98%	1383539-73-8	10mg	$283	2024-03-01	Buy
ApexBio Technology	C3387	HJC0197	1383539-73-8	10mg	$321	2021-12-16	Buy
ApexBio Technology	C3387	HJC0197	1383539-73-8	5mg	$192	2021-12-16	Buy

Product number	Packaging	Price	Buy
19092	1mg	$37	Buy
19092	5mg	$169	Buy
19092	10mg	$283	Buy
C3387	10mg	$321	Buy
C3387	5mg	$192	Buy

HJC0197 Chemical Properties,Uses,Production

Description

Exchange protein activated by cAMP (Epac) proteins mediate cAMP signaling independent of protein kinase A (PKA). HJC0197 is a cell-permeable inhibitor of Epac1 and Epac2 (IC₅₀ = 5.9 μM for Epac2). It inhibits Epac1-mediated Rap1-GDP exchange activity at 25 μM, but has no effect on cAMP-induced type I and II PKA activity at this concentration. Pretreatment of HEK293 cells expressing either Epac1 or Epac2 with 10 μM HJC0197 completely blocks Epac-mediated phosphorylation of Akt. HJC0197 has been used to study the role of Epac signaling in chondrogenesis in chicken micromass cultures.

HJC0197 Preparation Products And Raw materials

Raw materials

Preparation Products

HJC0197 Suppliers

Global( 29)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32686	60
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
LEAPCHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	43348	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	57511	58
Shanghai Lollane Biological Technology Co.,Ltd.	021-52996696，15000506266 15000506266		China	4153	55
Shanghai Beckham Medical Technology Co., Ltd	021-13816613772 13816613772	huahero21@sina.com	China	358	55
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9709	58
Shanghai YuanYe Biotechnology Co., Ltd.	021-61312847; 18021002903	3008007409@qq.com	China	27322	60
ShangHai Biochempartner Co.,Ltd	17754423994 17754423994	2853530910@QQ.com	China	8011	62

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
TargetMol Chemicals Inc.	58
InvivoChem	58
LEAPCHEM CO., LTD.	58
Aladdin Scientific	58
Shanghai Lollane Biological Technology Co.,Ltd.	55
Shanghai Beckham Medical Technology Co., Ltd	55
Shanghai EFE Biological Technology Co., Ltd.	58
Shanghai YuanYe Biotechnology Co., Ltd.	60
ShangHai Biochempartner Co.,Ltd	62

HJC0197 Spectrum

HJC0197(1383539-73-8)¹HNMR

HJC0197 5-Pyrimidinecarbonitrile, 4-cyclopentyl-2-[[(2,5-dimethylphenyl)methyl]thio]-1,6-dihydro-6-oxo- HJC 0197 (HJC0197) HJC0197,cAMP-signaling,activation,GEF,cellular,Ras,inhibit,HJC-0197,HJC 0197,phosphorylation,processes,Inhibitor 6-Cyclopentyl-2-((2,5-dimethylbenzyl)thio)-4-oxo-1,4-dihydropyrimidine-5-carbonitrile 1383539-73-8