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ChemicalBook >> CAS DataBase List >> HJC0197

HJC0197

HJC0197 price.
  • $37 - $1800
  • Product name: HJC0197
  • CAS: 1383539-73-8
  • MF: C19H21N3OS
  • MW: 339.45
  • EINECS:
  • MDL Number:MFCD27966183
  • Synonyms:HJC0197;5-Pyrimidinecarbonitrile, 4-cyclopentyl-2-[[(2,5-dimethylphenyl)methyl]thio]-1,6-dihydro-6-oxo-;HJC 0197 (HJC0197);HJC0197,cAMP-signaling,activation,GEF,cellular,Ras,inhibit,HJC-0197,HJC 0197,phosphorylation,processes,Inhibitor;6-Cyclopentyl-2-((2,5-dimethylbenzyl)thio)-4-oxo-1,4-dihydropyrimidine-5-carbonitrile
Price9 Properties Safety Information Description
9 prices
Selected condition：
Brand
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Cayman Chemical
  • DC Chemicals
Package
  • 1mg
  • 5MG
  • 10mg
  • 100mg
  • 250mg
  • 1g
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberINB0002135
  • Product description4-CYCLOPENTYL-2-(2,5-DIMETHYLBENZYLSULFANYL)-6-OXO-1,6-DIHYDROPYRIMIDINE-5-CARBONITRILE 95.00%
  • Packaging5MG
  • Price$495.22
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberC3387
  • Product descriptionHJC0197
  • Packaging5mg
  • Price$192
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberC3387
  • Product descriptionHJC0197
  • Packaging10mg
  • Price$321
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number19092
  • Product descriptionHJC0197 ≥98%
  • Packaging1mg
  • Price$37
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number19092
  • Product descriptionHJC0197 ≥98%
  • Packaging5mg
  • Price$169
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number19092
  • Product descriptionHJC0197 ≥98%
  • Packaging10mg
  • Price$283
  • Updated2024-03-01
  • Buy
  • ManufacturerDC Chemicals
  • Product numberDC21116
  • Product descriptionHJC0197 >98%
  • Packaging100mg
  • Price$450
  • Updated2021-12-16
  • Buy
  • ManufacturerDC Chemicals
  • Product numberDC21116
  • Product descriptionHJC0197 >98%
  • Packaging250mg
  • Price$900
  • Updated2021-12-16
  • Buy
  • ManufacturerDC Chemicals
  • Product numberDC21116
  • Product descriptionHJC0197 >98%
  • Packaging1g
  • Price$1800
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
American Custom Chemicals Corporation INB0002135 4-CYCLOPENTYL-2-(2,5-DIMETHYLBENZYLSULFANYL)-6-OXO-1,6-DIHYDROPYRIMIDINE-5-CARBONITRILE 95.00% 5MG $495.22 2021-12-16 Buy
ApexBio Technology C3387 HJC0197 5mg $192 2021-12-16 Buy
ApexBio Technology C3387 HJC0197 10mg $321 2021-12-16 Buy
Cayman Chemical 19092 HJC0197 ≥98% 1mg $37 2024-03-01 Buy
Cayman Chemical 19092 HJC0197 ≥98% 5mg $169 2024-03-01 Buy
Cayman Chemical 19092 HJC0197 ≥98% 10mg $283 2024-03-01 Buy
DC Chemicals DC21116 HJC0197 >98% 100mg $450 2021-12-16 Buy
DC Chemicals DC21116 HJC0197 >98% 250mg $900 2021-12-16 Buy
DC Chemicals DC21116 HJC0197 >98% 1g $1800 2021-12-16 Buy

Properties

solubility :DMF: 10 mg/ml; DMF:PBS(pH7.2) (1:2): 0.2 mg/ml; DMSO: 5 mg/ml
form :A crystalline solid

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Exchange protein activated by cAMP (Epac) proteins mediate cAMP signaling independent of protein kinase A (PKA). HJC0197 is a cell-permeable inhibitor of Epac1 and Epac2 (IC50 = 5.9 μM for Epac2). It inhibits Epac1-mediated Rap1-GDP exchange activity at 25 μM, but has no effect on cAMP-induced type I and II PKA activity at this concentration. Pretreatment of HEK293 cells expressing either Epac1 or Epac2 with 10 μM HJC0197 completely blocks Epac-mediated phosphorylation of Akt. HJC0197 has been used to study the role of Epac signaling in chondrogenesis in chicken micromass cultures.

Suppliers and manufacturers

ATK CHEMICAL COMPANY LIMITED
TargetMol Chemicals Inc.
InvivoChem
LEAPCHEM CO., LTD.
Aladdin Scientific Shanghai Lollane Biological Technology Co.,Ltd. Shanghai Beckham Medical Technology Co., Ltd Shanghai EFE Biological Technology Co., Ltd. Shanghai YuanYe Biotechnology Co., Ltd. ShangHai Biochempartner Co.,Ltd