MitoPQ
- CAS No.
- 1821370-28-8
- Chemical Name:
- MitoPQ
- Synonyms
- MitoPQ;MitoParaquat;MitoPQ (?MitoParaquat);MitoPQ, mitochondria-targeted redox cycler;1-Methyl-1'-(10-(triphenylphosphonio)decyl)-[4,4'-bipyridine]-1,1'-diium iodide
- CBNumber:
- CB74666144
- Molecular Formula:
- C39H46IN2P+2
- Molecular Weight:
- 700.69
- MDL Number:
- MOL File:
- 1821370-28-8.mol
| Product description | Number | Pack Size | Price |
| MitoPQ ≥98% | 18808 | 5mg | $238 |
| MitoPQ ≥98% | 18808 | 25mg | $887 |
| MitoPQ | 8144EJ | 5mg | $363 |
| storage temp. | Store at -20°C |
|---|---|
| solubility | DMF: 25 mg/ml; DMF:PBS(pH7.2) (1:2): 0.33 mg/ml; DMSO: 1 mg/ml; Ethanol: 0.33 mg/ml |
| form | A crystalline solid |
| color | Brown to reddish brown |
| InChIKey | KCPZNXZOMIOVHZ-UHFFFAOYSA-M |
| SMILES | [P+](C1C=CC=CC=1)(C1C=CC=CC=1)(C1C=CC=CC=1)CCCCCCCCCC[N+]1=CC=C(C2=CC=[N+](C)C=C2)C=C1.[I-] |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |     GHS06,GHS07,GHS08,GHS09 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301+H311-H330-H315-H319-H335-H372-H400-H410 | |||||||||
| Precautionary statements | P260-P264-P270-P271-P273-P280-P284-P301+P310-P330-P302+P352-P304+P340-P305+P351+P338-P312-P314-P320-P361+P364-P332+P313-P337+P313-P391-P403+P233-P405-P501 | |||||||||
| NFPA 704 |
|
MitoPQ price More Price(3)
MitoPQ Chemical Properties,Uses,Production
Description
MitoPQ, also known as MitoParaquat, is a redox cycler. MitoParaquat (MitoPQ) that comprises a triphenylphosphonium lipophilic cation conjugated to the redox cycler paraquat. MitoPQ accumulates selectively in the mitochondrial matrix driven by the membrane potential. Within the matrix, MitoPQ produces superoxide by redox cycling at the flavin site of complex I, selectively increasing superoxide production within mitochondria. MitoPQ increased mitochondrial superoxide in isolated mitochondria and cells in culture ~a thousand-fold more effectively than untargeted paraquat. MitoPQ was also more toxic than paraquat in the isolated perfused heart and in Drosophila in vivo. MitoPQ enables the selective generation of superoxide within mitochondria and is a useful tool to investigate the many roles of mitochondrial superoxide in pathology and redox signaling in cells and in vivo.
Uses
MitoPQ is a mitochondria-targeted redox cycler. MitoPQ produces superoxide by redox cycling at the flavin site of complex I, selectively increasing superoxide production within mitochondria. MitoPQ can be used in antioxidant study[1].
References
[1] Robb EL, et al. Selective superoxide generation within mitochondria by the targeted redox cycler MitoParaquat. Free Radic Biol Med. 2015 Dec;89:883-94. DOI:10.1016/j.freeradbiomed.2015.08.021
MitoPQ Preparation Products And Raw materials
Raw materials
Preparation Products
MitoPQ Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32435 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39035 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52923 | 58 | |
| Jiangsu Nanchuang Chemical and Life Health Research Institute Co., Ltd. | 15720605021 | zhang_lei@jsnchem.com | China | 1810 | 58 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9803 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 021-61312847; 18021002903 | 3008007409@qq.com | China | 71826 | 60 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 | sales@glpbio.cn | China | 6777 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11218 | 58 |
| Shanghai Anya Pharmaceutical Technology Co., LTD | 19106202509 | 3626423147@qq.com | China | 999 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8140 | 58 |
