TRPC3 Channel Inhibitor III, Pyr10 - Calbiochem
- CAS No.
- Chemical Name:
- TRPC3 Channel Inhibitor III, Pyr10 - Calbiochem
- Synonyms
- TRPC3 Channel Inhibitor III, Pyr10 - Calbiochem
- CBNumber:
- CB74818055
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
TRPC3 Channel Inhibitor III, Pyr10 - Calbiochem price More Price(1)
TRPC3 Channel Inhibitor III, Pyr10 - Calbiochem Chemical Properties,Uses,Production
General Description
A cell-permeable pyrazole derivative that acts as a selective blocker of the transient receptor potential cation channel TRPC3-medated ROCE (receptor-operated Ca2+ entry) and inhibits Carbachol- (Cat. No. 212385) induced Ca2+ entry in TRPC3-expressing HEK293 cells (IC50 = 0.72 μM; by Fura-2; peak current density pA/pF = -1.01 and -18.50, respectively, with or without 3 μM Pyr10 by whole cell clamp), while exhibiting much reduced potency against Stim1 and Orai1-coupled CRAC (Ca2+ release-activated Ca2+) channel-mediated SOCE (store-operated Ca2+ entry) in RBL-2H3 cells (IC50 = 13.08 μM; by Fura-2; pA/pF = -4.39 and -7.50, respectively, with or without 3 μM Pyr10). A great complement to Pyr2 (Cat. No. 203890), Pyr 3 (Cat. No. 648490), and Pyr6 (Cat. No. 203891) in Ca2+ signaling studies.
Biochem/physiol Actions
Cell permeable: yes
TRPC3 Channel Inhibitor III, Pyr10 - Calbiochem Preparation Products And Raw materials
Raw materials
Preparation Products
TRPC3 Channel Inhibitor III, Pyr10 - Calbiochem Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
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Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
Supplier | Advantage |
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Sigma-Aldrich | 80 |