TRPC3 Channel Inhibitor III, Pyr10 - Calbiochem

TRPC3 Channel Inhibitor III, Pyr10 - Calbiochem C화학적 특성, 용도, 생산

일반 설명

A cell-permeable pyrazole derivative that acts as a selective blocker of the transient receptor potential cation channel TRPC3-medated ROCE (receptor-operated Ca²⁺ entry) and inhibits Carbachol- (Cat. No. 212385) induced Ca²⁺ entry in TRPC3-expressing HEK293 cells (IC₅₀ = 0.72 μM; by Fura-2; peak current density pA/pF = -1.01 and -18.50, respectively, with or without 3 μM Pyr10 by whole cell clamp), while exhibiting much reduced potency against Stim1 and Orai1-coupled CRAC (Ca²⁺ release-activated Ca²⁺) channel-mediated SOCE (store-operated Ca²⁺ entry) in RBL-2H3 cells (IC₅₀ = 13.08 μM; by Fura-2; pA/pF = -4.39 and -7.50, respectively, with or without 3 μM Pyr10). A great complement to Pyr2 (Cat. No. 203890), Pyr 3 (Cat. No. 648490), and Pyr6 (Cat. No. 203891) in Ca²⁺ signaling studies.

Biochem/physiol Actions

Cell permeable: yes

TRPC3 Channel Inhibitor III, Pyr10 - Calbiochem 준비 용품 및 원자재

원자재

준비 용품

TRPC3 Channel Inhibitor III, Pyr10 - Calbiochem 공급 업체

공급자	전화	이메일	국가	제품 수	이점
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51471	80