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PROXYPHYLLINE

PROXYPHYLLINE structure

CAS No.: 603-00-9

Chemical Name:: PROXYPHYLLINE

Synonyms: MT;7-(2-Hydroxypropyl)-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione;Spasmolysin;PROXYPHYLINE;Thean;Theon;Brontyl;Spantin;Theoden;Sigophyl

CBNumber:: CB7492824

Molecular Formula:: C10H14N4O3

Molecular Weight:: 238.24

MDL Number:: MFCD00022833

MOL File:: 603-00-9.mol

Last updated:2023-11-24 18:23:39

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PROXYPHYLLINE Properties

Melting point	134-136°C
Boiling point	487.2±51.0 °C(Predicted)
Density	1.46±0.1 g/cm3(Predicted)
storage temp.	Inert atmosphere,Room Temperature
pka	14.55±0.20(Predicted)
color	White to Off-White
Water Solubility	285.7g/L(temperature not stated)
Merck	14,7905
CAS DataBase Reference	603-00-9(CAS DataBase Reference)
EWG's Food Scores	1
FDA UNII	13G1DMN4P0
ATC code	R03DA03
NIST Chemistry Reference	Proxyphylline(603-00-9)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302

Precautionary statements

P301+P312+P330

Hazard Codes

Risk Statements

Safety Statements

WGK Germany

RTECS

XH5907500

HS Code

2939.59.0000

NFPA 704

	0
2		0

PROXYPHYLLINE price More Price(40)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	S351288	7-(2-HYDROXYPROPYL)THEOPHYLLINE Aldrich	603-00-9	1g	$179	2024-03-01	Buy
Sigma-Aldrich	P3800000	Proxyphylline European Pharmacopoeia (EP) Reference Standard	603-00-9	p3800000	$220	2024-03-01	Buy
TCI Chemical	H1430	7-(2-Hydroxypropyl)theophylline >98.0%(HPLC)(N)	603-00-9	5g	$78	2024-03-01	Buy
TCI Chemical	H1430	7-(2-Hydroxypropyl)theophylline >98.0%(HPLC)(N)	603-00-9	25g	$196	2024-03-01	Buy
Cayman Chemical	20937	Proxyphylline ≥98%	603-00-9	500mg	$49	2024-03-01	Buy

Product number	Packaging	Price	Buy
S351288	1g	$179	Buy
P3800000	p3800000	$220	Buy
H1430	5g	$78	Buy
H1430	25g	$196	Buy
20937	500mg	$49	Buy

PROXYPHYLLINE Chemical Properties,Uses,Production

Chemical Properties

White Solid

Uses

A metabolite of Theophylline in human plasma.

Definition

ChEBI: Proxyphylline is an oxopurine.

Biological Activity

ki: 82 nm for bovine brain a1 adenosine receptorproxyphylline is an a1 adenosine receptor antagonist.the a1 adenosine receptor, the best characterized purinergic receptor family, can mediate responses via multiple pertussis toxin-sensitive gtp binding proteins to various different effectors.

in vitro

previous study showed that proxyphylline could selectively antagonize a1 adenosine receptors versus a2 adenosine receptors (ki = 850 μm for platelets) [1].

in vivo

in a previous study, rats that were allodynic following the vincristine injections were randomly allocated into four groups. theoesberiven f (a combination of proxyphylline and melilotus extract) was administered to rats. results showed that the decreased paw withdrawal threshold induced by vincristine injection was increased by theoesberiven f treatment and the increased withdrawal frequency to cold stimuli was also reduced by theoesberiven f treatment [2].

Purification Methods

Crystallise it from EtOH, aqueous MeOH or EtOAc. Roth Archiv Pharmazie 292 234 1959, Zelnik et al. Bull Soc Chim Fr 1733 1956, Beilstein 26 III/IV 2366.]

References

[1] u. schwabe, d. ukena and m. j. lohse. xanthine derivatives as antagonists at a1 and a2 adenosine receptors. naunyn-schmiedeberg's arch.pharmacol. 330,212-221 (1985).
[2] s. bang, y. s. kim and s. r. jeong. anti-allodynic effect of theoesberiven f in a vincristine-induced neuropathy model. exp. ther. med. 12(2), 799-803 (2016).
[3] selvig k. pharmacokinetics of proxyphylline in adults after intravenous and oral administration. eur j clin pharmacol. 1981 jan;19(2):149-55.

PROXYPHYLLINE Preparation Products And Raw materials

Raw materials

Preparation Products

PROXYPHYLLINE Suppliers

Global( 194)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Standardpharm Co. Ltd.	86-714-3992388	overseasales1@yongstandards.com	United States	14336	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49390	58
career henan chemical co	+86-0371-86658258 15093356674;	factory@coreychem.com	China	29826	58
SIMAGCHEM CORP	+86-13806087780	sale@simagchem.com	China	17367	58
Hefei TNJ Chemical Industry Co.,Ltd.	0551-65418671	sales@tnjchem.com	China	34572	58
AFINE CHEMICALS LIMITED	0571-85134551	info@afinechem.com	CHINA	15377	58
Finetech Industry Limited	+86-27-87465837 +8618971612321	info@finetechnology-ind.com	China	9702	58
Baoji Guokang Healthchem co.,ltd	+8615604608665 15604608665	dominicguo@gk-bio.com	CHINA	9427	58
Dayang Chem (Hangzhou) Co.,Ltd.	571-88938639 +8617705817739	info@dycnchem.com	CHINA	52867	58
Henan Alfa Chemical Co., Ltd	+8618339805032	alfa4@alfachem.cn	China	12755	58

Supplier	Advantage
Standardpharm Co. Ltd.	58
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
SIMAGCHEM CORP	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
AFINE CHEMICALS LIMITED	58
Finetech Industry Limited	58
Baoji Guokang Healthchem co.,ltd	58
Dayang Chem (Hangzhou) Co.,Ltd.	58
Henan Alfa Chemical Co., Ltd	58

View Lastest Price from PROXYPHYLLINE manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2023-11-25	PROXYPHYLLINE 603-00-9	US $35.68 / kg	1kg	99%	100kg	Wuhan Han Sheng New Material Technology Co.，Ltd
2023-11-25	Monophylline, Spasmolysin 603-00-9	US $35.67 / kg	1kg	99%	100kg	Wuhan Han Sheng New Material Technology Co.，Ltd
2023-11-25	Proxyphylline or 7-(2-Hydroxypropyl) Theophylline) 603-00-9	US $35.66 / kg	1kg	99%	100kg	Wuhan Han Sheng New Material Technology Co.，Ltd

PROXYPHYLLINE
603-00-9
US $35.68 / kg
99%
Wuhan Han Sheng New Material Technology Co.，Ltd

Monophylline, Spasmolysin
603-00-9
US $35.67 / kg
99%
Wuhan Han Sheng New Material Technology Co.，Ltd

Proxyphylline or 7-(2-Hydroxypropyl) Theophylline)
603-00-9
US $35.66 / kg
99%
Wuhan Han Sheng New Material Technology Co.，Ltd

PROXYPHYLLINE Spectrum

PROXYPHYLLINE(603-00-9)MS PROXYPHYLLINE(603-00-9)IR1 PROXYPHYLLINE(603-00-9)IR2

603-00-9(PROXYPHYLLINE)Related Search:

Diprophylline diniprofylline Tazifylline Xanthinol nicotinate PROXYPHYLLINE

Theophylline Xanthinol 1,3-DIMETHYL-7-(OXIRAN-2-YLMETHYL)-2,3,6,7-TETRAHYDRO-1H-PURINE-2,6-DIONE (S)-Proxyphylline (R)-Proxyphylline

Xantifibrate 8-CHLORO-7-(3-CHLORO-2-HYDROXYPROPYL)-1,3-DIMETHYL-2,3,6,7-TETRAHYDRO-1H-PURINE-2,6-DIONE 7-(3-CHLORO-2-HYDROXYPROPYL)-1,3-DIMETHYL-2,3,6,7-TETRAHYDRO-1H-PURINE-2,6-DIONE 8-BROMO-7-(2-HYDROXYPROPYL)-1,3-DIMETHYL-2,3,6,7-TETRAHYDRO-1H-PURINE-2,6-DIONE 8-BROMO-7-(3-CHLORO-2-HYDROXYPROPYL)-1,3-DIMETHYL-2,3,6,7-TETRAHYDRO-1H-PURINE-2,6-DIONE

1,3-DIMETHYL-8-MORPHOLINO-7-(2-OXIRANYLMETHYL)-2,3,6,7-TETRAHYDRO-1H-2,6-PURINEDIONE 8-BROMO-7-(2-HYDROXYBUTYL)-1,3-DIMETHYL-2,3,6,7-TETRAHYDRO-1H-PURINE-2,6-DIONE 8-(BENZYLAMINO)-7-(3-CHLORO-2-HYDROXYPROPYL)-1,3-DIMETHYL-2,3,6,7-TETRAHYDRO-1H-2,6-PURINEDIONE

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7-(BETA-HYDROXYPROPYL)THEOPHYLLINE [1,3-DIMETHYL-7-(2-HYDROXYPROPYL)-2,6-DIOXOPURINE] 7-(B-hydroxypropyl)theophylline Proxylphylline Proxyphylline BP 1H-Purine-2,6-dione, 3,7-dihydro-7-(2-hydroxypropyl)-1,3-dimethyl- (9CI) 2,6-Dioxo-3,7-dihydro-7-(2-hydroxypropyl)-1,3-dimethylpurine 7-(b-Hydroxypropyl)-1,3-dimethylxanthine 7-(2-hydroxypropyl)-theophyllin 7-(2-Hydroxypropyl)theophylline 7-(beta-Hydroxypropyl)-1,3-dimethylxanthine beta-Hydroxypropyltheophylline beta-Oxypropyltheophyllin Brontyl Hydroxypropyltheophylline Monophylline Oxypropyltheophylline Proxiphylline Proxy-Retardoral Purophyllin Sanwaphyllin Sigophyl Spantin Thean Theoden Theon Theophylline, 7-(2-hydroxypropyl)- PROXYPHYLLIN PROXYPHYLLINE 1,3-Dimethyl-7-(2-hydroxypropyl)xanthine 1H-Purine-2,6-dione, 3,7-dihydro-1,3-dimethyl-7-(2-hydroxypropyl)- 1H-Purine-2,6-dione, 3,7-dihydro-7-(2-hydroxypropyl)-1,3-dimethyl- 2-Hydroxypropyl-7-theophylline 3,7-dihydro-1,3-dimethyl-7-(2-hydroxypropyl)-1h-purine-6-dione 3,7-Dihydro-7-(2-hydroxypropyl)-1,3-dimethyl-1H-purine-2,6-dione 3,7-dihydro-7-(2-hydroxypropyl)-1,3-dimethyl-1h-purine-6-dione b-Hydroxypropyltheophylline NSC 163343 Theophylline, 7-(2-hydroxypropyl)- (6CI, 7CI, 8CI) 7-(BETA-HYDROXYPROPYL)-THEOPHYLLINE 99% BP2003 (1,3-Dimethyl-7-[2-hydroxypropyl]-2,6-dioxopurine), Proxyphylline 7-(2-hydroxypropyl)-1,3-dimethyl-purine-2,6-dione 7-(2-hydroxypropyl)-1,3-dimethylpurine-2,6-dione 7-(2-hydroxypropyl)-1,3-dimethyl-xanthine 7-(2-Hydroxypropyl)-1,3-dimethyl-1H-purine-2,6(3H,7H)-dione Monophylline, Spasmolysin Proxyphylline or 7-(2-Hydroxypropyl) Theophylline) Diprophylline Impurity 4（Diprophylline EP Impurity D） Diprophylline EP Impurity D 7-(2-Hydroxypropyl)theophylline> Proxyphylline CRS 7-(β-Hydroxypropyl)theophylline Pentoxifylline Impurity 1 MT Spasmolysin PROXYPHYLINE 7-(2-Hydroxypropyl)-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione 7-[(2RS)-2-hydroxypropyl]-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione (proxyphylline).