CHLORISONDAMINE DIIODIDE
- CAS No.
- 96750-66-2
- Chemical Name:
- CHLORISONDAMINE DIIODIDE
- Synonyms
- Chlorisondamine (iodide);CHLORCHLORISONDAMINE DIIODIDEISONDAMINE DIIODIDE;4,5,6,7-tetrachloro-2-methyl-2-[2-(trimethylammonium)ethyl]isoindolinium diiodide
- CBNumber:
- CB7497364
- Molecular Formula:
- C14Cl4H20I2N2
- Molecular Weight:
- 611.94
- MDL Number:
- MFCD01074794
- MOL File:
- 96750-66-2.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H400 | |||||||||
| Precautionary statements | P273-P301+P312+P330 | |||||||||
| Hazard Codes | Xn,N | |||||||||
| Risk Statements | 22-50 | |||||||||
| Safety Statements | 60-61 | |||||||||
| RIDADR | UN 3077 9 / PGIII | |||||||||
| WGK Germany | 2 | |||||||||
| NFPA 704 |
|
CHLORISONDAMINE DIIODIDE price More Price(13)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | C5366 | Chlorisondamine diiodide ≥98% (HPLC), white solid | 96750-66-2 | 10mg | $190 | 2024-03-01 | Buy |
| Sigma-Aldrich | C5366 | Chlorisondamine diiodide ≥98% (HPLC), white solid | 96750-66-2 | 50mg | $714 | 2024-03-01 | Buy |
| Cayman Chemical | 20119 | Chlorisondamine (iodide) ≥98% | 96750-66-2 | 1mg | $37 | 2024-03-01 | Buy |
| Cayman Chemical | 20119 | Chlorisondamine (iodide) ≥98% | 96750-66-2 | 5mg | $108 | 2024-03-01 | Buy |
| Cayman Chemical | 20119 | Chlorisondamine (iodide) ≥98% | 96750-66-2 | 10mg | $161 | 2024-03-01 | Buy |
CHLORISONDAMINE DIIODIDE Chemical Properties,Uses,Production
Description
Chlorisondamine is an antagonist of nicotinic acetylcholine receptors (nAChRs; IC50 = 1.8 μM in rat striatal synaptosomes) and a ganglion blocker. It decreases dopamine release induced by nicotine (Item Nos. 16535 | 20887) in a dose-dependent manner in rat striatal synaptosomes at concentrations ranging from 0-100 μM. The effect of chlorisondamine is long-lasting, with a 10 mg/kg dose blocking nicotine-induced stimulant activity for at least five weeks. Chlorisondamine (5 μg, i.c.v.) prevents rats from acquiring a (–)-nicotine-induced conditioned taste aversion response, a model of the aversive effects of nicotine. It also inhibits autonomic ganglia, providing approximately 50% inhibition of the contractile response in feline superior cervical ganglion nictitating membrane preparations when administered at a dose of 50 mg/kg.
Uses
Chlorisondamine diiodide has been used:
- as a nicotinic receptor antagonist to test its effect on trinitrobenzene sulfonic acid (TNBS)-induced colitis
- as an irreversible nicotinic acetylcholine(nAChR) blocker to pre-treat brain samples to test its effect on cytochrome P450 2B (CYP2B) induction
- as a ganglionic blocker to test its effect on regulating corticosterone levels in rat with chronic stress
Biochem/physiol Actions
Chlorisondamine diiodide mediates ganglionic and central blockade.
CHLORISONDAMINE DIIODIDE Preparation Products And Raw materials
Raw materials
Preparation Products
CHLORISONDAMINE DIIODIDE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 14059 | 65 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
| Angel Pharmatech, Ltd. | 17317130613 | 3358272972@qq.com | China | 3237 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8141 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing@energy-chemical.com | China | 44941 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24131 | 58 |
| Nantong QuanYi Biotechnology Co., Ltd | 0513-66337626 18051384581 | sales@chemhifuture.com | China | 4030 | 58 |