BAY1238097
- CAS No.
- 1564268-08-1
- Chemical Name:
- BAY1238097
- Synonyms
- BAY1238097;BAY1238097,BAY-1238097;3H-2,3-Benzodiazepine-3-carboxamide, 4,5-dihydro-7,8-dimethoxy-N,4-dimethyl-1-[4-(4-methyl-1-piperazinyl)phenyl]-, (4S)-
- CBNumber:
- CB75419682
- Molecular Formula:
- C25H33N5O3
- Molecular Weight:
- 451.56
- MDL Number:
- MFCD31807603
- MOL File:
- 1564268-08-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Density | 1.22±0.1 g/cm3(Predicted) |
|---|---|
| storage temp. | Store at -20°C |
| solubility | DMSO : 150 mg/mL (332.18 mM) |
| form | Solid |
| pka | 15.43±0.60(Predicted) |
| color | Light yellow to yellow |
| FDA UNII | M9ALI41OQR |
BAY1238097 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | PMC26808 | BAY1238097 | 1564268-08-1 | 25mg | $832 | 2026-06-04 | Buy |
| Biosynth | PMC26808 | BAY1238097 | 1564268-08-1 | 50mg | $1331.5 | 2026-06-04 | Buy |
| Biosynth | PMC26808 | BAY1238097 | 1564268-08-1 | 100mg | $2131 | 2026-06-04 | Buy |
| ChemScene | CS-0045172 | BAY1238097 99.02% | 1564268-08-1 | 5mg | $146 | 2026-06-04 | Buy |
| ChemScene | CS-0045172 | BAY1238097 99.02% | 1564268-08-1 | 10mg | $244 | 2026-06-04 | Buy |
BAY1238097 Chemical Properties, Uses, Production
Uses
BAY1238097 is a potent and selective inhibitor of BET binding to histones and has strong anti-proliferative activity in different AML (acute myeloid leukemia) and MM (multiple myeloma) models through down-regulation of c-Myc levels and its downstream transcriptome (IC50 <100 nM).
in vivo
BAY 1238097 shows strong efficacy in the AML and MM models. BAY 1238097 has in vivo anti-tumour activity in lymphoma models[1][2].
BAY 1238097 is well tolerated at 10-15 mg/kg applied daily over 9-14 days in different disease models, with no obvious toxicity[1][2].
| Animal Model: | Severe combined immunodeficiency (SCID) female mice (9-12 weeks old) inoculated subcutaneously into the right flank with 5×106 SU-DHL-8 cells/mouse suspended in 0.1 mL of matrigel or with O |
| Dosage: | 15 mg/kg (maximal tolerated dose). |
| Administration: | Orally daily for 12 days (on day 21 post-tumour inoculation). |
| Result: | Showed strong efficacy in the AML models THP-1, MOLM-13 and KG-1, with T/C between 13 and 20%. Also active in MM models in a human IGH-cyclin D1 translocated MOLP-8 model with a T/C of 3%[2]. |
References
[1] Lejeune, P., et al. (2015) Abstract 3524: BAY 1238097, a novel BET inhibitor with strong efficacy in hematological tumor models. Cancer Research, 75(15 Suppl), 884.
[2] Bernasconi E, et al. Preclinical evaluation of the BET bromodomain inhibitor BAY 1238097 for the treatment of lymphoma. Br J Haematol. 2017 Sep;178(6):936-948. DOI:10.1111/bjh.14803
BAY1238097 Preparation Products And Raw materials
Raw materials
Preparation Products
BAY1238097 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Sichuan Wei Keqi Biological Technology Co., Ltd. | 028-81700200 18116577057 | 3003855609@qq.com | China | 7690 | 56 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Beijing Solarbio Science & Tecnology Co., Ltd. | 17801761073 18101056239 | 3193328036@qq.com | China | 28149 | 68 |
| Fan De(Beijing) Biotechnology Co., Ltd. | 15911056312 | liming@bio-fount.com | China | 9718 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6378 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6288 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11123 | 58 |
| Shanghai hongqu biomedical technology co. LTD | 88888888888 | hongquchem@qq.com | China | 5123 | 58 |
| InvivoChem | 13549236410 | sales@invivochem.cn | China | 6745 | 58 |
View Latest Price from BAY1238097 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-15 | BAY1238097
1564268-08-1
|
$47.00 | 98.10% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-07-15 | BAY1238097
1564268-08-1
|
$47.00 | 98.10% | 10g | TargetMol Chemicals Inc. |
-
- BAY1238097
1564268-08-1
- $47.00
- 98.10%
- TargetMol Chemicals Inc.
-
- BAY1238097
1564268-08-1
- $47.00
- 98.10%
- TargetMol Chemicals Inc.
