1-NAPHTHYLACETYL SPERMINE TRIHYDROCHLORIDE
- CAS No.
- 1049731-36-3
- Chemical Name:
- 1-NAPHTHYLACETYL SPERMINE TRIHYDROCHLORIDE
- Synonyms
- NASPM (hydrochloride);1-NAPHTHYLACETYL SPERMINE TRIHYDROCHLORIDE;Naspm trihydrochloride (1-Naphthylacetyl spermine);1-Naphthyl acetyl spermine (NASPM) trihydrochloride;inhibit,Inhibitor,Naspm trihydrochloride,iGluR,Ionotropic glutamate receptors
- CBNumber:
- CB7736755
- Molecular Formula:
- C22H35ClN4O
- Molecular Weight:
- 407
- MDL Number:
- MFCD01321052
- MOL File:
- Mol file
SAFETY
Risk and Safety Statements
| Safety Statements | 22-24/25 |
|---|---|
| WGK Germany | 3 |
1-NAPHTHYLACETYL SPERMINE TRIHYDROCHLORIDE price More Price(20)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | N193 | 1-Naphthylacetyl spermine trihydrochloride | 1049731-36-3 | 5MG | $189 | 2023-06-20 | Buy |
| Sigma-Aldrich | N193 | 1-Naphthylacetyl spermine trihydrochloride | 1049731-36-3 | 25MG | $647 | 2023-06-20 | Buy |
| Cayman Chemical | 18453 | NASPM (hydrochloride) ≥95% | 1049731-36-3 | 1mg | $25 | 2024-03-01 | Buy |
| Cayman Chemical | 18453 | NASPM (hydrochloride) ≥95% | 1049731-36-3 | 5mg | $94 | 2024-03-01 | Buy |
| Cayman Chemical | 18453 | NASPM (hydrochloride) ≥95% | 1049731-36-3 | 10mg | $135 | 2024-03-01 | Buy |
1-NAPHTHYLACETYL SPERMINE TRIHYDROCHLORIDE Chemical Properties,Uses,Production
Chemical Properties
White Solid
Uses
1-Naphthylacetyl Spermine Trihydrochloride is a poliamine amide as potent Spermidine uptake inhibitor.
Biological Activity
naspm trihydrochloride is a selective antagonist of ca2+-permeable α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (ampa) receptors. ampa receptors are glutamate-gated ion channels that play central roles in the mammalian brain, mediating fast excitatory synaptic transmission and underlying several forms of synaptic plasticity. on excitatory neurons in adult animals, two types of ampa receptors are primarily expressed, namely heteromeric channels composed of glur1 and glur2 subunits (glur1/2 receptors), as well as channels composed of glur2 and glur3 subunits (glur2/3 receptors). naspm trihydrochloride blocks ampa receptors lacking the glur2 subunit, with an ic50 value of 0.3 μm for glur1 homomers.1. nilsen a, england pm. a subtype-selective, use-dependent inhibitor of native ampa receptors. journal of the american chemical society, 2007, 129(16): 4902-4903.2. koike m, iino m, ozawa s. blocking effect of 1-naphthyl acetyl spermine on ca2+-permeable ampa receptors in cultured rat hippocampal neurons. neuroscience research, 1997, 29(1): 27-36.
Biochem/physiol Actions
Blocks Ca2+ permeable AMPA receptor channels.
storage
+4°C (desiccate)
1-NAPHTHYLACETYL SPERMINE TRIHYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
1-NAPHTHYLACETYL SPERMINE TRIHYDROCHLORIDE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131980 | 58 |
| ELSA BIOTECHNOLOGY CO.,LTD. | 15261860116 | sales@elsa-biotech.com | China | 99 | 55 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32344 | 50 |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7553 | 61 |
View Lastest Price from 1-NAPHTHYLACETYL SPERMINE TRIHYDROCHLORIDE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-01-19 | 1-NAPHTHYLACETYL SPERMINE TRIHYDROCHLORIDE
1049731-36-3
|
US $1.00 / KG | 1KG | 99.0% | 100kg | Career Henan Chemical Co |
-
- 1-NAPHTHYLACETYL SPERMINE TRIHYDROCHLORIDE
1049731-36-3
- US $1.00 / KG
- 99.0%
- Career Henan Chemical Co