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ChemicalBook >> CAS DataBase List >>1-BOC-4-SPIRO-[3-(2-PYRROLIDINONE)] PIPERIDINE

1-BOC-4-SPIRO-[3-(2-PYRROLIDINONE)] PIPERIDINE

1-BOC-4-SPIRO-[3-(2-PYRROLIDINONE)] PIPERIDINE Structure
1-BOC-4-SPIRO-[3-(2-PYRROLIDINONE)] PIPERIDINE structure
CAS No.
268550-48-7
Chemical Name:
1-BOC-4-SPIRO-[3-(2-PYRROLIDINONE)] PIPERIDINE
Synonyms
CPD0982;8-Boc-2,8-diazaspiro[4.5]decan-1-one;8-Boc-1-oxo-2,8-diazaspiro[4.5]decane;1-BOC-4-SPIRO-[3-(2-PYRROLIDINONE)] PIPERIDIN;1-oxo-2,8-diazaspiro[4.5]decane-8-carboxylate;1-BOC-4-SPIRO-[3-(2-PYRROLIDINONE)] PIPERIDINE;2,8-Diazaspiro[4.5]decan-1-one, N8-BOC protected;tert-butyl 1-oxo-2,8-diazaspiro[4.5]decane-8-carbo;TERT-BUTYL 1-OXO-2,8-DIAZASPIRO[4.5]DECANE-8-CARBOXYLATE;1-Oxo-2,8-diazaspiro[4.5]decane-8-carboxylic acid tert-butyl ester
CBNumber:
CB7792225
Molecular Formula:
C13H22N2O3
Molecular Weight:
254.33
MDL Number:
MFCD08461248
MOL File:
268550-48-7.mol
Last updated:2025-08-05 18:30:54
Product description Number Pack Size Price
tert-Butyl1-oxo-2,8-diazaspiro[4.5]decane-8-carboxylate B694580 500mg $220
tert-Butyl 1-oxo-2,8-diazaspiro[4.5]decane-8-carboxylate 066674 500mg $108
8-Boc-2,8-diazaspiro[4.5]decan-1-one 95+% AS13147 1g $115
2,8-Diazaspiro[4.5]decan-1-one,N8-BOCprotected 97% OR924090 1g $120
tert-Butyl 1-oxo-2,8-diazaspiro[4.5]decane-8-carboxylate FB141682 100mg $120
More product size
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1-BOC-4-SPIRO-[3-(2-PYRROLIDINONE)] PIPERIDINE Properties

Boiling point 424.9±38.0 °C(Predicted)
Density 1.15
storage temp. 2-8°C
pka 16.00±0.20(Predicted)
Appearance White to off-white Solid
InChI InChI=1S/C13H22N2O3/c1-12(2,3)18-11(17)15-8-5-13(6-9-15)4-7-14-10(13)16/h4-9H2,1-3H3,(H,14,16)
InChIKey ADPIEGXXCABJCH-UHFFFAOYSA-N
SMILES C1(=O)C2(CCN(C(OC(C)(C)C)=O)CC2)CCN1

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P280-P261-P271
HazardClass  IRRITANT
HS Code  2932990090

1-BOC-4-SPIRO-[3-(2-PYRROLIDINONE)] PIPERIDINE price More Price(44)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC B694580 tert-Butyl1-oxo-2,8-diazaspiro[4.5]decane-8-carboxylate 268550-48-7 500mg $220 2021-12-16 Buy
Matrix Scientific 066674 tert-Butyl 1-oxo-2,8-diazaspiro[4.5]decane-8-carboxylate 268550-48-7 500mg $108 2021-12-16 Buy
Activate Scientific AS13147 8-Boc-2,8-diazaspiro[4.5]decan-1-one 95+% 268550-48-7 1g $115 2021-12-16 Buy
Apolloscientific OR924090 2,8-Diazaspiro[4.5]decan-1-one,N8-BOCprotected 97% 268550-48-7 1g $120 2021-12-16 Buy
Biosynth Carbosynth FB141682 tert-Butyl 1-oxo-2,8-diazaspiro[4.5]decane-8-carboxylate 268550-48-7 100mg $120 2021-12-16 Buy
Product number Packaging Price Buy
B694580 500mg $220 Buy
066674 500mg $108 Buy
AS13147 1g $115 Buy
OR924090 1g $120 Buy
FB141682 100mg $120 Buy

1-BOC-4-SPIRO-[3-(2-PYRROLIDINONE)] PIPERIDINE Chemical Properties,Uses,Production

Synthesis

1,4-Piperidinedicarboxylic acid, 4-(cyanomethyl)-, 1-(1,1-dimethylethyl) 4-ethyl ester

495414-81-8

1-BOC-4-SPIRO-[3-(2-PYRROLIDINONE)] PIPERIDINE

268550-48-7

B) Synthesis of tert-butyl 1-oxo-2,8-diazaspiro[4.5]decane-8-carboxylate 4-(Cyanomethyl)-1,4-piperidinedicarboxylic acid-1-(1,1-dimethylethyl)4-ethyl ester (2.5 g) was dissolved in methanol (50 mL), and cobalt(II) chloride hexahydrate (1.0 g) and sodium borohydride (1.6 g) were added sequentially under ice bath cooling. The reaction mixture was stirred by keeping the ice bath cool for 2 h. Subsequently, the ice bath was removed and stirring was continued for 2 h at room temperature. The reaction system was then warmed to 60°C for 1 hour. After completion of the reaction, 28% ammonia solution was added to the system and the resulting precipitate was removed by filtration. The filtrate was extracted with ethyl acetate, the organic layers were combined and dried over anhydrous magnesium sulfate. The solvent was removed by concentration under reduced pressure and the resulting crude product was purified by silica gel column chromatography (eluent: ethyl acetate) to afford the target compound tert-butyl 1-oxo-2,8-diazaspiro[4.5]decane-8-carboxylate (1.1 g). The product was characterized by 1H NMR (300 MHz, DMSO-d6): δ 1.25-1.35 (2H, m), 1.40 (9H, s), 1.45-1.58 (2H, m), 1.90-1.98 (2H, m), 2.90 (2H, brs), 3.16 (2H, t, J=7.2Hz), 3.76-3.86 ( 2H, m), 7.56 (1H, brs).

References

[1] Patent: EP2933247, 2015, A1. Location in patent: Paragraph 0334

1-BOC-4-SPIRO-[3-(2-PYRROLIDINONE)] PIPERIDINE Preparation Products And Raw materials

Raw materials

1,4-Piperidinedicarboxylic acid, 4-(cyanomethyl)-, 1-(1,1-dimethylethyl) 4-ethyl ester Methanol Sodium borohydride Cobalt chloride hexahydrate

Preparation Products

2,8-Diazaspiro[4.5]decan-1-one, hydrochloride (1:1)

1-BOC-4-SPIRO-[3-(2-PYRROLIDINONE)] PIPERIDINE Suppliers

Global( 130)Suppliers
Supplier Tel Email Country ProdList Advantage
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD 		+86-13017695106 +86-13676922317 jiuyitime@fdachem.com China 16514 58
Hi-Tech Chemistry Corp 		0519-86626038 yuhh@hitechem.com CHINA 810 58
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29850 58
Accela ChemBio Inc. 		+1-858-6993322 info@accelachem.com United States 21193 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd 		+8613580539051 joe@yuhengpharm.com CHINA 21142 58
Pharmahands (Taizhou) Co., Ltd. 		+86 523-86200360 CHINA 358 58
Apeloa Pharmaceutical Co., Ltd. 		+86-0571-87635730 +8615858229168 chem1022@hengdian-group.com China 1478 58
Hefei Hirisun Pharmatech Co., Ltd 		+8615056975894 shawn@hirisunpharm.com CHINA 9911 58
Supplier Advantage
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD 		58
Hi-Tech Chemistry Corp 		58
ATK CHEMICAL COMPANY LIMITED 		60
career henan chemical co 		58
Accela ChemBio Inc. 		58
Alchem Pharmtech,Inc. 		58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd 		58
Pharmahands (Taizhou) Co., Ltd. 		58
Apeloa Pharmaceutical Co., Ltd. 		58
Hefei Hirisun Pharmatech Co., Ltd 		58

View Lastest Price from 1-BOC-4-SPIRO-[3-(2-PYRROLIDINONE)] PIPERIDINE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
tert-butyl 1-oxo-2,8-diazaspiro[4.5]decane-8-carboxylate pictures 2025-10-13 tert-butyl 1-oxo-2,8-diazaspiro[4.5]decane-8-carboxylate
268550-48-7
 US $2.00-6.00 / kg 1kg 99% 100kg ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
1-BOC-4-SPIRO-[3-(2-PYRROLIDINONE)] PIPERIDINE pictures 2025-04-04 1-BOC-4-SPIRO-[3-(2-PYRROLIDINONE)] PIPERIDINE
268550-48-7
 US $0.00-0.00 / KG 1KG 98% 1Ton Henan Aochuang Chemical Co.,Ltd.
tert-butyl 1-oxo-2,8-diazaspiro[4.5]decane-8-carboxylate pictures 2021-04-08 tert-butyl 1-oxo-2,8-diazaspiro[4.5]decane-8-carboxylate
268550-48-7
 US $890.00 / Kg/Bag 1g 98% 20kg/month Pharmahands (Taizhou) Co., Ltd.

1-BOC-4-SPIRO-[3-(2-PYRROLIDINONE)] PIPERIDINE Spectrum

1-BOC-4-SPIRO-[3-(2-PYRROLIDINONE)] PIPERIDINE(268550-48-7)1HNMR

268550-48-7(1-BOC-4-SPIRO-[3-(2-PYRROLIDINONE)] PIPERIDINE)Related Search:

TERT-BUTYL 4-(AMINOCARBONYL)TETRAHYDROPYRIDINE-1(2H)-CARBOXYLATE 2,8-DIAZA-SPIRO[4.5]DECANE-8-CARBOXYLIC ACID TERT-BUTYL ESTER 3-[N-(2-AMINO)BENZYL-2-PYRROLIDINONE]-4'-N-BOC-SPIRO-PIPERIDINE 1-BOC-4-SPIRO-[3-(2-PYRROLIDINONE)] PIPERIDINE 3-[N-(3-AMINO)BENZYL-2-PYRROLIDINONE]-4'-N-BOC-SPIRO-PIPERIDINE
3-[N-(4-AMINO)BENZYL-2-PYRROLIDINONE]-4'-N-BOC-SPIRO-PIPERIDINE 1-BOC-4-FORMYL-4-METHYL-PIPERIDINE

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1-BOC-4-SPIRO-[3-(2-PYRROLIDINONE)] PIPERIDINE TERT-BUTYL 1-OXO-2,8-DIAZASPIRO[4.5]DECANE-8-CARBOXYLATE 2,8-Diazaspiro[4.5]decane-8-carboxylicacid,1-oxo-,1,1-dimethylethylester 1-Oxo-2,8-diazaspiro[4.5]decane-8-carboxylic acid 1,1-dimethylethyl ester 1-Oxo-2,8-diazaspiro[4.5]decane-8-carboxylic acid tert-butyl ester 1-oxo-2,8-diazaspiro[4.5]decane-8-carboxylate 8-Boc-1-oxo-2,8-diazaspiro[4.5]decane tert-butyl 1-oxo-2,8-diazaspiro[4.5]decane-8-carbo 8-Boc-2,8-diazaspiro[4.5]decan-1-one CPD0982 1-BOC-4-SPIRO-[3-(2-PYRROLIDINONE)] PIPERIDIN tert-Butyl 1-oxo-2,8-diazaspiro[4.5]decane-8-carboxylate - [B0956] 2,8-Diazaspiro[4.5]decan-1-one, N8-BOC protected 268550-48-7