Etifoxine
- CAS No.
- 21715-46-8
- Chemical Name:
- Etifoxine
- Synonyms
- 36-801;Etifoxin;Etifoxine;HOE-36801;HOE-36-801;etafenoxine;Etifoxine (HOE36801);6-chloro-N-ethyl-4-methyl-4-phenyl-3,1-benzoxazin-2-amine;2-Ethylamino-6-chloro-4-methyl-4-phenyl-4H-3,1-benzoxazine;6-Chloro-2-ethylamino-4-methyl-4-phenyl-4H-3,1-benzoxazine
- CBNumber:
- CB7875113
- Molecular Formula:
- C17H17ClN2O
- Molecular Weight:
- 300.78
- MDL Number:
- MFCD00868190
- MOL File:
- 21715-46-8.mol
- MSDS File:
- SDS
| Melting point | 90-92℃ |
|---|---|
| Boiling point | 421.2±55.0 °C(Predicted) |
| Density | 1.1716 (rough estimate) |
| vapor pressure | 0-1Pa at 20-25℃ |
| refractive index | 1.5800 (estimate) |
| storage temp. | Store at -20°C |
| solubility |
DMSO:60.0(Max Conc. mg/mL);199.47(Max Conc. mM) DMF:30.0(Max Conc. mg/mL);99.74(Max Conc. mM) DMF:PBS (pH 7.2) (1:8):0.1(Max Conc. mg/mL);0.33(Max Conc. mM) Ethanol:20.0(Max Conc. mg/mL);66.49(Max Conc. mM) |
| form | Solid:particulate/powder |
| pka | 4.89±0.40(Predicted) |
| LogP | 4.09-4.52 at 21-25℃ and pH7 |
| FDA UNII | X24X82MX4X |
| ATC code | N05BX03 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H401-H302 | |||||||||
| Precautionary statements | P264-P270-P301+P312-P330-P501-P273-P501 | |||||||||
| Toxicity | LD50 orally in mice: 12 g/kg (Hoffmann) | |||||||||
| NFPA 704 |
|
Etifoxine price More Price(12)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 15999 | Etifoxine ≥98% | 21715-46-8 | 5mg | $86 | 2024-03-01 | Buy |
| Cayman Chemical | 15999 | Etifoxine ≥98% | 21715-46-8 | 10mg | $129 | 2024-03-01 | Buy |
| Cayman Chemical | 15999 | Etifoxine ≥98% | 21715-46-8 | 25mg | $296 | 2024-03-01 | Buy |
| Cayman Chemical | 15999 | Etifoxine ≥98% | 21715-46-8 | 50mg | $546 | 2024-03-01 | Buy |
| ChemScene | CS-1104 | Etifoxine 99.87% | 21715-46-8 | 100mg | $610 | 2021-12-16 | Buy |
Etifoxine Chemical Properties,Uses,Production
Originator
Circupon,Troponwerke,W. Germany
Definition
ChEBI: Etifoxine is a benzoxazine.
Manufacturing Process
30 parts of 1-(3'-hydroxyphenyl)-2-(N-benzylaminomethyl)-ethan-1-one are
mixed with 100 parts of pyridine and 30 parts of pivalic anhydride and
dissolved while warming. After heating for 1 hour under reflux, the acylation
is complete. After concentrating the reaction solution, the product is
precipitated from acetone/ether. Yield: 96.4% of 1-(3'-pivaloyloxyphenyl)-2-
(N-benzylaminomethyl)-ethan-1-one.
3 parts of palladium/charcoal (10% strength) are prehydrogenated in water,
thereafter 10 parts of 1-(3'-pivaloyloxyphenyl)-2-(N-benzylaminoethyl)-ethan-
1-one, dissolved in a 10-fold amount of water, are added dropwise at room
temperature and hydrogenation is carried out until 1 mol of hydrogen has
been taken up. After filtering off the catalyst, a further 3 parts of
palladium/charcoal are added and hydrogenation is carried out until a further
mol of hydrogen has been taken up. The catalyst is separated off and after
removal of the solvent the hydrogenation product is reprecipitated from
acetone/petroleum ether and from methanol/ether until it is pure according to
thin layer chromatography. Yield: 38.8% of 1-(3'-pivaloyloxyphenyl)-2-
ethylaminoethanol-1 hydroxide, melting point 208°C to 209°C.
Therapeutic Function
Tranquilizer
Etifoxine Preparation Products And Raw materials
Etifoxine Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24738 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7553 | 61 |
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4863 | 58 |
| AdooQ BioScience, LLC | +1 (866) 930-6790 | info@adooq.com | United States | 2784 | 58 |
| LETOPHARM LIMITED | +86-21-5821 5861 | sales@letopharm.com | China | 2384 | 58 |
| Codow Chemical Co.,Ltd. | 18620099427 | amy@howeipharm.com | China | 17698 | 55 |
| Supplier | Advantage |
|---|---|
| TargetMol Chemicals Inc. | 58 |
| InvivoChem | 58 |
| LEAP CHEM CO., LTD. | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | 58 |
| Aladdin Scientific | 58 |
| Haoyuan Chemexpress Co., Ltd. | 61 |
| MedChemexpress LLC | 58 |
| AdooQ BioScience, LLC | 58 |
| LETOPHARM LIMITED | 58 |
| Codow Chemical Co.,Ltd. | 55 |