ketazolam
- CAS No.
- 27223-35-4
- Chemical Name:
- ketazolam
- Synonyms
- Anxon;U-28774;Anseren;Unakalm;Loftran;Ansieten;ketazolam;NSC 338158;ketazolam USP/EP/BP;Ketazolam (1.0mg/ml in Acetonitrile)
- CBNumber:
- CB7925768
- Molecular Formula:
- C20H17ClN2O3
- Molecular Weight:
- 368.81
- MDL Number:
- MOL File:
- 27223-35-4.mol
| Melting point | 182-183.5° (sinters at 170°) |
|---|---|
| Boiling point | 645.0±55.0 °C(Predicted) |
| Density | 1.41±0.1 g/cm3(Predicted) |
| solubility | DMF: 5 mg/ml; DMSO: 5 mg/ml; DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml; Methanol: 1 mg/ml |
| form | A crystalline solid |
| pka | -0.84±0.60(Predicted) |
| Stability | Unstable in Solution |
| FDA UNII | 92A214MD7Y |
| ATC code | N05BA10 |
SAFETY
Risk and Safety Statements
| RIDADR | 3249 |
|---|---|
| HazardClass | 6.1(b) |
| PackingGroup | III |
| Toxicity | cat,LD50,intraperitoneal,3900mg/kg (3900mg/kg),Medicamentos de Actualidad. Vol. 16, Pg. 293, 1980. |
ketazolam Chemical Properties,Uses,Production
Description
Benzodiazepines are psychoactive compounds that act as sedatives, hypnotics, anxiolytics, anticonvulsants, and muscle relaxants. Ketazolam is a benzodiazepine derivative that was used as an anxiolytic in the 1980s. Tolerance within fifteen days, physical dependence, and benzodiazepine withdrawal syndrome are associated with ketazolam use. This product is intended for forensic purposes.
Originator
Anxon,Beecham,UK,1980
Uses
A psychotropic benzodiazepine derivative with hypnotic and anxiolytic properties. Controlled Substance.
Definition
ChEBI: Ketazolam is a benzodiazepine.
Manufacturing Process
A solution of 0.7 g of 2-(2-amino-N-methylacetamido)-5-chlorobenzophenone in 10 ml of a 50% solution (by weight) of diketene in acetone is refluxed for 3 hours and then evaporated to give a brown oil. The oil is chromatographed on 200 g of silica gel using a 1:1 (by volume) mixture of ethyl acetate cyclohexane; 25 ml fractions are collected. Fractions 11-14 are combined, mixed with chloroform, evaporated and triturated with ether to give 0.337 g of 11-chloro-8,12b-dihydro-2,8-dimethyl-12b-phenyl-4H-[1,3]oxazino[3,2-d] [1.4] benzodiazepine-4,7(6H)-dione as a pale yellow solid, MP 174°C to 176°C.
Therapeutic Function
Antianxiety
ketazolam Preparation Products And Raw materials
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