CX546 (1-(1,4-BENZODIOXAN-6-YLCARBONYL)P
- CAS No.
- 215923-54-9
- Chemical Name:
- CX546 (1-(1,4-BENZODIOXAN-6-YLCARBONYL)P
- Synonyms
- GR 87;BDP 17;CX-546;BDP-17,CX546,GR87;CX546 (1-(1,4-BENZODIOXAN-6-YLCARBONYL)P;1-(1,4-Benzodioxan-6-ylcarbonyl)piperidine;1-(2,3-Dihydro-1,4-benzodioxin-6-ylcarbonyl)piperidine;(2,3-Dihydro-1,4-benzodioxin-6-yl)-1-piperidinylmethanone;2,3-dihydro-1,4-benzodioxin-6-yl(piperidin-1-yl)methanone;Methanone,(2,3-dihydro-1,4-benzodioxin-6-yl)-1-piperidinyl-
- CBNumber:
- CB7972429
- Molecular Formula:
- C14H17NO3
- Molecular Weight:
- 247.29
- MDL Number:
- MFCD01860868
- MOL File:
- 215923-54-9.mol
- MSDS File:
- SDS
Melting point | 71-73°C |
---|---|
Boiling point | 422.8±44.0 °C(Predicted) |
Density | 1?+-.0.06 g/cm3(Predicted) |
storage temp. | 2-8°C |
solubility | DMSO: ≥10mg/mL |
pka | -1.08±0.20(Predicted) |
form | solid |
color | white to off-white |
FDA UNII | PV6YEC8983 |
CX546 (1-(1,4-BENZODIOXAN-6-YLCARBONYL)P price More Price(28)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | C271 | CX546 ≥98% (HPLC), solid | 215923-54-9 | 10mg | $277 | 2024-03-01 | Buy |
Sigma-Aldrich | C271 | CX546 ≥98% (HPLC), solid | 215923-54-9 | 50mg | $395.6 | 2024-03-01 | Buy |
Sigma-Aldrich | 5.05016 | CX546 - CAS 215923-54-9 - Calbiochem | 215923-54-9 | 10MG | $188 | 2022-05-15 | Buy |
Tocris | 2980 | CX546 ≥99%(HPLC) | 215923-54-9 | 10 | $150 | 2021-12-16 | Buy |
Tocris | 2980 | CX546 ≥99%(HPLC) | 215923-54-9 | 50 | $585 | 2021-12-16 | Buy |
CX546 (1-(1,4-BENZODIOXAN-6-YLCARBONYL)P Chemical Properties,Uses,Production
Uses
It is one of a series of AMPA modulators matergic AMPA receptors.
Uses
CX546 has been used as positive allosteric modulator for the glutamatergic receptor α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) in mice.
General Description
CX546, a benzoylpiperidine derivative ampakine is an analog of CX516.
Biological Activity
AMPA receptor potentiator. Binds specifically to the agonist bound non-desensitized receptor, most likely destabilizing the desensitized receptor conformation. Enhances cognitive function in rats.
Biochem/physiol Actions
CX546 has antipsychotic functionality and has the potential to treat schizophrenia. It improves the defects associated with the prepulse inhibition (PPI) and latent inhibition (LI)?in mice lacking metabotropic glutamate receptor type 5 (mGluR5). Additionally, CX546 potentiates synaptic plasticity, elicits neuroprotection and promotes the neurotrophin expression.
storage
Store at +4°C
CX546 (1-(1,4-BENZODIOXAN-6-YLCARBONYL)P Preparation Products And Raw materials
Raw materials
Preparation Products
CX546 (1-(1,4-BENZODIOXAN-6-YLCARBONYL)P Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32836 | 60 |
Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49392 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29822 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
GIHI CHEMICALS CO.,LIMITED | +8618058761490 | info@gihichemicals.com | China | 50003 | 58 |
Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 | product@acmec-e.com | China | 33350 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
SHANGHAI KEAN TECHNOLOGY CO., LTD. | +8613817748580 | cooperation@kean-chem.com | China | 40068 | 58 |
View Lastest Price from CX546 (1-(1,4-BENZODIOXAN-6-YLCARBONYL)P manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2020-01-03 | CX546 (1-(1,4-BENZODIOXAN-6-YLCARBONYL)P
215923-54-9
|
US $1.00 / KG | 1KG | 99% | 200kg | Career Henan Chemical Co |
- CX546 (1-(1,4-BENZODIOXAN-6-YLCARBONYL)P
215923-54-9
- US $1.00 / KG
- 99%
- Career Henan Chemical Co