MORACIZINE HYDROCHLORIDE
- CAS No.
- 29560-58-5
- Chemical Name:
- MORACIZINE HYDROCHLORIDE
- Synonyms
- en313;etmozin;ethmozine;ethmosine;MORACIZINE HCL;Moricizine hydrochloride;MORACIZINE HYDROCHLORIDE;Moricizine Hydrochloride (250 mg);Moricizine Hydrochloride (1446950);ethyl10-(3-morpholinopropionyl)phenothiazine-2-carbamatehydrochloride
- CBNumber:
- CB8115063
- Molecular Formula:
- C22H26ClN3O4S
- Molecular Weight:
- 463.98
- MDL Number:
- MFCD00329917
- MOL File:
- 29560-58-5.mol
| Melting point | 189° (dec) |
|---|---|
| FDA UNII | 71OK3Z1ESP |
| EPA Substance Registry System | Moricizine hydrochloride (29560-58-5) |
SAFETY
Risk and Safety Statements
| HS Code | 2934302700 |
|---|---|
| Toxicity | LD50 in mice, rats (mg/kg): 36, 12 i.v.; in mice (mg/kg): 131 i.p. (Kaverina) |
MORACIZINE HYDROCHLORIDE price More Price(2)
MORACIZINE HYDROCHLORIDE Chemical Properties,Uses,Production
Description
Moricizine hydrochloride is a phenothiazine derivative with antiarrhythmic activity developed by the Soviet Academy of Medical Sciences. It is licensed to Dupont-Sanko in a joint venture. Moricizine hydrochloride is the first drug licensed to a U.S. company by the Soviet Union and was introduced by Dupont in the U.S. in 1990 for specific use in Iife-threatening ventricular arrhythmias. This narrow indication reflects its proarrhythmic potential. The incidence of this adverse reaction, however, is lower than that of other antiarrhythmic agents.
Originator
Acad. Med. Sci. (USSR)
Uses
Moricizine Hydrochloride is a Phenothiazine (P318040) derivative, which It was used as an antiarrhythmic agent. It is also shown that moracizine is effective in suppressing premature ventricular contractions, couplets, and nonsustained ventricular tachycardia.
Uses
Cardiac depressant (anti-arrhythmic).
Definition
ChEBI: A hydrochloride salt obtained from equimola amounts of moricizine and hydrogen chloride.
Manufacturing Process
To a solution of 10 g (0.035 mole) of ethyl phenthiazine-2-carbamate in 30 ml
of anhydrous toluene is added dropwise 5.3 g (0.042 mole) of 3-
chloropropionyl chloride, and the mixture is refluxed at 110-120°C for 4
hours, followed by clarifying the mixture with activated carbon and cooling it
to room temperature. A precipitate of ethyl 10-(3-chloropropionyl)-
phenthiazine-2-carbamate is removed by filtration. The yield is 10.2 g (77.5%
of the theoretical amount), M.P. 169-170°C.
10.2 g of ethyl 10-(3-chloropropionyl)-phenthiazine-2-carbamate ester is
dissolved in 50 ml of toluene, 4.72 g of morpholine is added thereto, and the
mixture is refluxed at 110-120°C for a period of 3 hours. A precipitate of
morpholine hydrochloride is removed by filtration, and the filtrate is washed
with water in order to remove excess morpholine, followed by acidulating with
dilute hydrochloric acid to adjust the pH of the filtrate is adjusted at 3. The
acidic aqueous layer is separated, clarified by treatment with activated carbon
and made alkaline until the pH equals 8-9. This procedure yields the free base
of ethyl 10-(β-morpholylpropionyl)-phenthiazine-2-carbamate, M.P. 156-
157°C.
The free base thus obtained is extracted with toluene, the extract is dried over
magnesium sulphate and to the anhydrous toluene solution is added an
anhydrous ethereal solution of hydrogen chloride until the precipitation of the
target compound is complete. This procedure yields 9.53 g (76.2% of the
theoretical amount) of ethyl 10-(β-morpholylpropionyl)-phenthiazine-2-
carbamate hydrochloride. After recrystallization from dichloroethane, the
target compound melts at 189°C. (decomp.).
brand name
Ethmozine (Shire).
Therapeutic Function
Antiarrhythmic
MORACIZINE HYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
MORACIZINE HYDROCHLORIDE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12470 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 | sales@tnjchem.com | China | 34571 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23556 | 58 |
| Sinopharm Chemical Reagent Co,Ltd. | 86-21-63210123 | sj_scrc@sinopharm.com | China | 9823 | 79 |
| Hubei Jusheng Technology Co.,Ltd | 027-59599241 18871490274 | 1400878000@qq.com | China | 9972 | 58 |
| Beijing Solarbio Science & Tecnology Co., Ltd. | 010-50973186 4009686088 | 3193328036@qq.com | China | 18352 | 68 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing@energy-chemical.com | China | 44941 | 58 |
| Zhengzhou Akem Chemical Co., Ltd | 13303867194 | 3001317055@qq.com | China | 9627 | 58 |
| Hunan Zhangjiajie Hengkang Biological Pharmaceutical Co., LTD | 0731-85561023 18973109536 | hengkangapi@hengkangapi.com | China | 336 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24017 | 58 |
View Lastest Price from MORACIZINE HYDROCHLORIDE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2023-09-13 | MORACIZINE HYDROCHLORIDE
29560-58-5
|
US $0.00 / KG | 1KG | 99% | 50000KG/month | Hebei Mojin Biotechnology Co., Ltd |
-
- MORACIZINE HYDROCHLORIDE
29560-58-5
- US $0.00 / KG
- 99%
- Hebei Mojin Biotechnology Co., Ltd
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