ChemicalBook >> CAS DataBase List >>2-Propenamide, N-[4-fluoro-3-[[2-[(1-methyl-1H-pyrazol-4-yl)amino]-5-[4-(trifluoromethyl)phenyl]-4-pyrimidinyl]amino]phenyl]-

2-Propenamide, N-[4-fluoro-3-[[2-[(1-methyl-1H-pyrazol-4-yl)amino]-5-[4-(trifluoromethyl)phenyl]-4-pyrimidinyl]amino]phenyl]-

2-Propenamide, N-[4-fluoro-3-[[2-[(1-methyl-1H-pyrazol-4-yl)amino]-5-[4-(trifluoromethyl)phenyl]-4-pyrimidinyl]amino]phenyl]- structure

CAS No.: 2769954-39-2

Chemical Name:: 2-Propenamide, N-[4-fluoro-3-[[2-[(1-methyl-1H-pyrazol-4-yl)amino]-5-[4-(trifluoromethyl)phenyl]-4-pyrimidinyl]amino]phenyl]-

Synonyms: BLU-451;N-(4-Fluoro-3-((2-((1-methyl-1H-pyrazol-4-yl)amino)-5-(4-(trifluoromethyl)phenyl)pyrimidin-4-yl)amino)phenyl)acrylamide;2-Propenamide, N-[4-fluoro-3-[[2-[(1-methyl-1H-pyrazol-4-yl)amino]-5-[4-(trifluoromethyl)phenyl]-4-pyrimidinyl]amino]phenyl]-

CBNumber:: CB811785019

Molecular Formula:: C24H19F4N7O

Molecular Weight:: 497.45

MDL Number:

MOL File:: 2769954-39-2.mol

Last updated:2025-04-18 09:52:48

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2-Propenamide, N-[4-fluoro-3-[[2-[(1-methyl-1H-pyrazol-4-yl)amino]-5-[4-(trifluoromethyl)phenyl]-4-pyrimidinyl]amino]phenyl]- Properties

Density	1.39±0.1 g/cm3(Predicted)
form	Solid
pka	12.22±0.70(Predicted)
color	White to off-white

2-Propenamide, N-[4-fluoro-3-[[2-[(1-methyl-1H-pyrazol-4-yl)amino]-5-[4-(trifluoromethyl)phenyl]-4-pyrimidinyl]amino]phenyl]- Chemical Properties,Uses,Production

Uses

Pebezertinib (BLU 451) is an orally active inhibitor for EGFR. Pebezertinib exhibits the ability to penetrate the central nervous system (CNS). Pebezertinib can be used for research about non-small cell lung cancer carrying EGFR exon 20 insertion[1].

References

[1] Zhou Y, et al., Anti-PD-1/L1 antibody plus anti-VEGF antibody vs. plus VEGFR-targeted TKI as first-line therapy for unresectable hepatocellular carcinoma: a network meta-analysis. Explor Target Antitumor Ther. 2024;5(3):568-580. DOI:10.37349/etat.2024.00236

2-Propenamide, N-[4-fluoro-3-[[2-[(1-methyl-1H-pyrazol-4-yl)amino]-5-[4-(trifluoromethyl)phenyl]-4-pyrimidinyl]amino]phenyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

2-Propenamide, N-[4-fluoro-3-[[2-[(1-methyl-1H-pyrazol-4-yl)amino]-5-[4-(trifluoromethyl)phenyl]-4-pyrimidinyl]amino]phenyl]- Suppliers

Global( 20)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Jinan Chuanbei Biotechnology Co., Ltd	18654547380; 15269175648	qingyan7590@163.com	China	22	58
Shanghai Lollane Biological Technology Co.,Ltd.	021-52996696，15000506266 15000506266		China	4611	55
Changzhou Chenhong Biotechnology Co., Ltd.	0519-85788828 13775037613	sales@chemrenpharm.com	China	3600	58
Wuxi Donghe Pharmaceutical Technology Co., Ltd.	63313187 15358055255	63313187@qq.com	China	1988	58
Chunchuang (Wuhan) Technology Co., Ltd	15727060112	yutianchun2007@126.com	China	9998	58
Hubei Zhongshan Medical Technology Co., Ltd	027-61907345 13397111514	w13397111514@163.com	China	1010	58
Shanghai UCHEM Inc.	18939844854	sales6@myuchem.com	China	5007	58
Bide Pharmatech Ltd.	400-1647117 13681763483	product02@bidepharm.com	China	62072	58
Hubei Weideli Chemical Reagent Co.，Ltd.	13339985473	C13339985473@163.com	China	4992	58
Jiangsu Magic Biotechnology Co., Ltd	13921770081	svp01@magicbiotech.cn	China	508	58

Supplier	Advantage
Jinan Chuanbei Biotechnology Co., Ltd	58
Shanghai Lollane Biological Technology Co.,Ltd.	55
Changzhou Chenhong Biotechnology Co., Ltd.	58
Wuxi Donghe Pharmaceutical Technology Co., Ltd.	58
Chunchuang (Wuhan) Technology Co., Ltd	58
Hubei Zhongshan Medical Technology Co., Ltd	58
Shanghai UCHEM Inc.	58
Bide Pharmatech Ltd.	58
Hubei Weideli Chemical Reagent Co.，Ltd.	58
Jiangsu Magic Biotechnology Co., Ltd	58

2-Propenamide, N-[4-fluoro-3-[[2-[(1-methyl-1H-pyrazol-4-yl)amino]-5-[4-(trifluoromethyl)phenyl]-4-pyrimidinyl]amino]phenyl]- BLU-451 N-(4-Fluoro-3-((2-((1-methyl-1H-pyrazol-4-yl)amino)-5-(4-(trifluoromethyl)phenyl)pyrimidin-4-yl)amino)phenyl)acrylamide 2769954-39-2 C24H19F4N7O