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5-TRANS FLUPROSTENOL

CAS No.
57968-83-9
Chemical Name:
5-TRANS FLUPROSTENOL
Synonyms
5-TRANS FLUPROSTENOL;WWSWYXNVCBLWNZ-BDFMIYKPSA-N;Travoprost Impurity 1(5- trans Fluprostenol);9ALPHA,11ALPHA,15R-TRIHYDROXY-16-(3-(TRIFLUOROMETHYL)PHENOXY)-17-18,19,20-TETRANOR-PROSTA-5E,13E-DIEN-1-OIC ACID;5-Heptenoic acid, 7-[3,5-dihydroxy-2-[3-hydroxy-4-[3-(trifluoromethyl)phenoxy]-1-butenyl]cyclopentyl]-, [1R-[1α(E),2β(1E,3R*),3α,5α]]- (9CI)
CBNumber:
CB8118105
Molecular Formula:
C23H29F3O6
Molecular Weight:
458.47
MDL Number:
MFCD05863949
MOL File:
Mol file
Last updated:2023-06-08 09:03:09

5-TRANS FLUPROSTENOL Properties

solubility DMF: 100 mg/ml; DMSO: 100 mg/ml; Ethanol: 100 mg/ml; PBS (pH 7.2): 15 mg/ml

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS02,GHS07
Signal word  Danger
Hazard statements  H225-H319
Precautionary statements  P210-P233-P240-P241-P242-P243-P264-P280-P303+P361+P353-P305+P351+P338-P337+P313-P370+P378-P403+P235-P501
NFPA 704
3
2 0

5-TRANS FLUPROSTENOL price More Price(4)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 16776 5-trans Fluprostenol ≥95% 57968-83-9 1mg $87 2024-03-01 Buy
Cayman Chemical 16776 5-trans Fluprostenol ≥95% 57968-83-9 5mg $384 2024-03-01 Buy
Cayman Chemical 16776 5-trans Fluprostenol ≥95% 57968-83-9 10mg $680 2024-03-01 Buy
AK Scientific 1461AH 5-TransFluprostenol 57968-83-9 5mg $525 2021-12-16 Buy
Product number Packaging Price Buy
16776 1mg $87 Buy
16776 5mg $384 Buy
16776 10mg $680 Buy
1461AH 5mg $525 Buy

5-TRANS FLUPROSTENOL Chemical Properties,Uses,Production

Description

Travoprost is the Alcon trade name for fluprostenol isopropyl ester, an F-series prostaglandin analog which has been approved for use as an ocular hypotensive drug.1 Fluprostenol isopropyl ester is a prodrug which is converted by esterase enzymatic activity in the cornea to yield the corresponding free acid, fluprostenol.2 5-trans Fluprostenol is an impurity that is routinely found in bulk preparations of fluprostenol in amounts ranging from 1-3%. This impurity occurs in the finished prodrug Travoprost in similar amounts. The pharmacology of 5-trans fluprostenol has not been studied extensively to date.

References

1. Hellberg, M.R., Sallee, V.L., McLaughlin, M.A., et al. Preclinical efficacy of travoprost, a potent and selective FP prostaglandin receptor agonist J. Ocul. Pharmacol. Ther. 17(5),421-432(2001).
2. Sorbera, L.A., and Casta?er, J. Travoprost Drugs Future 25(1),41-45(2000).

5-TRANS FLUPROSTENOL Preparation Products And Raw materials

Raw materials

Preparation Products

5-TRANS FLUPROSTENOL Suppliers

Global( 15)Suppliers
Supplier Tel Email Country ProdList Advantage
Standardpharm Co. Ltd.
86-714-3992388 overseasales1@yongstandards.com United States 14336 58
China National Standard Pharmaceutical Corporation Limited
+8615391658522 overseasales@yongstandards.com China 11927 58
Shanghai Boyle Chemical Co., Ltd. 021-50182298 021-50180596 sales@boylechem.com China 2210 55
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9709 58
Shanghai Hongye Biotechnology Co. Ltd 400-9205774 sales@glpbio.cn China 6870 58
Shenzhen Polymeri Biochemical Technology Co., Ltd. +86-400-002-6226 13028896684 sales@rrkchem.com China 55827 58
Hangzhou Synstar pharmaceutical Technology CO.,Ltd 0571-85361029 synstar518@163.com China 1991 58
Guangzhou Dreampharm Biotechnology Co., Ltd. 17825480238 3008233717@qq.com China 9844 12
Jinan blalong chemical co. LTD 2710913286@.com 1513643261@qq.com China 14253 58
Guangzhou Juntang Technology Co., Ltd 020-36607679 13502246435 sales@dmstandards.com China 10951 58
9ALPHA,11ALPHA,15R-TRIHYDROXY-16-(3-(TRIFLUOROMETHYL)PHENOXY)-17-18,19,20-TETRANOR-PROSTA-5E,13E-DIEN-1-OIC ACID WWSWYXNVCBLWNZ-BDFMIYKPSA-N Travoprost Impurity 1(5- trans Fluprostenol) 5-Heptenoic acid, 7-[3,5-dihydroxy-2-[3-hydroxy-4-[3-(trifluoromethyl)phenoxy]-1-butenyl]cyclopentyl]-, [1R-[1α(E),2β(1E,3R*),3α,5α]]- (9CI) 5-TRANS FLUPROSTENOL 57968-83-9