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ChemicalBook >> CAS DataBase List >>3,3,4-Trimethyl-1-[1-[(tetrahydro-2H-pyran-4-yl)methyl]-1H-indol-3-yl]-4-penten-1-one

3,3,4-Trimethyl-1-[1-[(tetrahydro-2H-pyran-4-yl)methyl]-1H-indol-3-yl]-4-penten-1-one

3,3,4-Trimethyl-1-[1-[(tetrahydro-2H-pyran-4-yl)methyl]-1H-indol-3-yl]-4-penten-1-one Structure
3,3,4-Trimethyl-1-[1-[(tetrahydro-2H-pyran-4-yl)methyl]-1H-indol-3-yl]-4-penten-1-one structure
CAS No.
2244599-90-2
Chemical Name:
3,3,4-Trimethyl-1-[1-[(tetrahydro-2H-pyran-4-yl)methyl]-1H-indol-3-yl]-4-penten-1-one
Synonyms
3,3,4-Trimethyl-1-[1-[(tetrahydro-2H-pyran-4-yl)methyl]-1H-indol-3-yl]-4-penten-1-one
CBNumber:
CB813346386
Molecular Formula:
C22H29NO2
Molecular Weight:
339.47
MDL Number:
MOL File:
2244599-90-2.mol
Last updated:2023-05-25 10:22:58
Product description Number Pack Size Price
A-834735 Degradant ≥95% 14165 1 mg $117
A-834735 Degradant ≥95% 14165 5 mg $319
A-834735 Degradant ≥95% 14165 10 mg $578
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3,3,4-Trimethyl-1-[1-[(tetrahydro-2H-pyran-4-yl)methyl]-1H-indol-3-yl]-4-penten-1-one Properties

Boiling point 495.4±25.0 °C(Predicted)
Density 1.06±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)
solubility DMF: 20 mg/ml; DMSO: 10 mg/ml; Ethanol: 30 mg/ml; Ethanol:PBS (pH 7.2) (1:3): 0.25 mg/ml

3,3,4-Trimethyl-1-[1-[(tetrahydro-2H-pyran-4-yl)methyl]-1H-indol-3-yl]-4-penten-1-one price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 14165 A-834735 Degradant ≥95% 2244599-90-2 1 mg $117 2024-03-01 Buy
Cayman Chemical 14165 A-834735 Degradant ≥95% 2244599-90-2 5 mg $319 2024-03-01 Buy
Cayman Chemical 14165 A-834735 Degradant ≥95% 2244599-90-2 10 mg $578 2024-03-01 Buy
Product number Packaging Price Buy
14165 1 mg $117 Buy
14165 5 mg $319 Buy
14165 10 mg $578 Buy

3,3,4-Trimethyl-1-[1-[(tetrahydro-2H-pyran-4-yl)methyl]-1H-indol-3-yl]-4-penten-1-one Chemical Properties,Uses,Production

Description

A-834735 is an indole-derived cannabinoid (CB) with a 3-tetramethylcyclopropylmethanone substituent. It acts as a full agonist at both the central CB1 and peripheral CB2 receptors in rat with Ki values of 4.6 and 0.31 nM, respectively, and EC50 values of 12 and 0.21 nM, respectively.1 A-834735 readily crosses the blood-brain barrier, dose-dependently reversing thermal hyperalgesia without adverse side effects in a rat neuropathic pain model.1 A-834735 degradant is a common impurity observed during GC-MS analysis of samples containing A-834735. The opened ring of the degradant is presumed to be produced during heating of A-834735. This structure gives rise to a prominent fragment ion that is 15 amu greater than the base peak of A-834735. This pattern is consistent with McLafferty rearrangement of the degradant which does not occur with the parent compound.2

References

1. Chin, C.L., Tovcimak, A.E., Hradil, V.P., et al. Differential effects of cannabinoid receptor agonists on regional brain activity using pharmacological MRI Br. J. Pharmacol. 153(2),367-379(2008).
2. McLafferty, F.W. Mass spectrometric analysis. Molecular rearrangements Anal. Chem. 31(1),82-87(1959).

3,3,4-Trimethyl-1-[1-[(tetrahydro-2H-pyran-4-yl)methyl]-1H-indol-3-yl]-4-penten-1-one Preparation Products And Raw materials

Raw materials

Preparation Products

3,3,4-Trimethyl-1-[1-[(tetrahydro-2H-pyran-4-yl)methyl]-1H-indol-3-yl]-4-penten-1-one Suppliers

Global( 2)Suppliers
Supplier Tel Email Country ProdList Advantage
Cayman Chemical Company 800-364-9897 sales@caymanchem.com China 6838 58
Supplier Advantage
Cayman Chemical Company 58
3,3,4-Trimethyl-1-[1-[(tetrahydro-2H-pyran-4-yl)methyl]-1H-indol-3-yl]-4-penten-1-one 2244599-90-2