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SR-1114

SR-1114 structure

CAS No.: 2769141-82-2

Chemical Name:: SR-1114

Synonyms: SR-1114

CBNumber:: CB813731526

Molecular Formula:: C39H42N8O11S

Molecular Weight:: 830.87

MDL Number:

MOL File:: 2769141-82-2.mol

Last updated:2025-04-18 09:52:49

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SR-1114 Properties

Density	1.56±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)
pka	7.13±0.50(Predicted)
form	Solid
color	White to off-white

SR-1114 Chemical Properties,Uses,Production

Uses

SR-1114 is a first-in-class PROTAC ENL degrader. SR-1114 elicits rapid, CRBN-dependent degradation of ENL with DC50s of 150 nM, 311 nM, and 1.65 μM in MV4;11 , MOLM-13, and OCI/AML-2 cells, respectively[1].

IC 50

Cereblon

References

[1] Leopold Garnar-Wortzel,?et al. Chemical Inhibition of ENL/AF9 YEATS Domains in Acute Leukemia. ACS Cent Sci.?2021 May 26;7(5):815-830. DOI:10.1021/acscentsci.0c01550

SR-1114 Preparation Products And Raw materials

Raw materials

Preparation Products

SR-1114 Suppliers

Global( 2)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Nantong QuanYi Biotechnology Co., Ltd	0513-66337626 18051384581	sales@chemhifuture.com	China	5927	58
Shanghai Fine Biotech Co.，Ltd	18221172427	sale@fine-biotech.com	China	2735	58

Supplier	Advantage
Nantong QuanYi Biotechnology Co., Ltd	58
Shanghai Fine Biotech Co.，Ltd	58

SR-1114 2769141-82-2