ER degrader 7
- CAS No.
- 2922929-63-1
- Chemical Name:
- ER degrader 7
- Synonyms
- ER degrader 7;Selenocyanic acid, 6-[[4-[6-[[(2-fluorophenyl)(2,2,2-trifluoroethyl)amino]sulfonyl]-3-(4-hydroxyphenyl)-7-oxabicyclo[2.2.1]hept-2-en-2-yl]phenyl]amino]-6-oxohexyl ester
- CBNumber:
- CB814256411
- Molecular Formula:
- C33H31F4N3O5SSe
- Molecular Weight:
- 736.64
- MDL Number:
- MOL File:
- 2922929-63-1.mol
ER degrader 7 Chemical Properties,Uses,Production
Uses
ER degrader 7 (Compound 35t) is an ERα and ERβ degrader. ER degrader 7 inhibits tubulin polymerization. ER degrader 7 inhibits cell viability with IC50s of 0.06, 2.56, 15.84, 1.59, 1.67, 1.37 μM for MCF-7, T47D, MCF-10A, LCC2, T47D D538G, and T47D Y537S cells respectively. ER degrader 7 also inhibits breast cancer tumor growth[1].
References
[1] Deng X, et al. Identification of Novel Dual-Target Estrogen Receptor α Degraders with Tubulin Inhibitory Activity for the Treatment of Endocrine-Resistant Breast Cancer. J Med Chem. 2023 Aug 24;66(16):11094-11117. DOI:10.1021/acs.jmedchem.3c00465
ER degrader 7 Preparation Products And Raw materials
Raw materials
Preparation Products
ER degrader 7 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +17819995354 | marketing@targetmol.com | United States | 19962 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29641 | 58 |
| Supplier | Advantage |
|---|---|
| TargetMol Chemicals Inc. | 58 |
| TargetMol Chemicals Inc. | 58 |
View Lastest Price from ER degrader 7 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-10-27 | ER degrader 7
2922929-63-1
|
US $0.00-0.00 / mg | 10g | TargetMol Chemicals Inc. |
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- ER degrader 7
2922929-63-1
- US $0.00-0.00 / mg
- TargetMol Chemicals Inc.
