4-FLUORO-N-[2-[4-(7-METHOXY-1-NAPHTHALENYL)-1-PIPERAZINYL]ETHYL]BENZAMIDE HYDROCHLORIDE
![4-FLUORO-N-[2-[4-(7-METHOXY-1-NAPHTHALENYL)-1-PIPERAZINYL]ETHYL]BENZAMIDE HYDROCHLORIDE Structure](CAS/GIF/135721-98-1.gif)
- CAS No.
- 135721-98-1
- Chemical Name:
- 4-FLUORO-N-[2-[4-(7-METHOXY-1-NAPHTHALENYL)-1-PIPERAZINYL]ETHYL]BENZAMIDE HYDROCHLORIDE
- Synonyms
- S14506HCl;S 14506 HYDROCHLORIDE;1-((4-fluorobenzoylamino)ethyl)-4-(7-methoxy-1-naphthyl)piperazine hydrochloride;4-Fluoro-N-(2-(4-(7-Methoxynaphthalen-1-yl)piperazin-1-yl)ethyl)benzaMide hydrochloride;4-FLUORO-N-[2-[4-(7-METHOXY-1-NAPHTHALENYL)-1-PIPERAZINYL]ETHYL]BENZAMIDE HYDROCHLORIDE
- CBNumber:
- CB8161035
- Molecular Formula:
- C24H27ClFN3O2
- Molecular Weight:
- 443.94
- MDL Number:
- MFCD00910294
- MOL File:
- 135721-98-1.mol
| storage temp. | Desiccate at RT |
|---|---|
| FDA UNII | 098102RI3W |
4-FLUORO-N-[2-[4-(7-METHOXY-1-NAPHTHALENYL)-1-PIPERAZINYL]ETHYL]BENZAMIDE HYDROCHLORIDE price More Price(6)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Tocris | 1771 | S14506hydrochloride ≥99%(HPLC) | 135721-98-1 | 10 | $164 | 2021-12-16 | Buy |
| Tocris | 1771 | S14506hydrochloride ≥99%(HPLC) | 135721-98-1 | 50 | $648 | 2021-12-16 | Buy |
| Usbiological | 256547 | S 14506 hydrochloride | 135721-98-1 | 10mg | $466 | 2021-12-16 | Buy |
| TRC | S080863 | S14506 | 135721-98-1 | 10mg | $155 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0008837 | 4-FLUORO-N-[2-[4-(7-METHOXY-1-NAPHTHALENYL)-1-PIPERAZINYL]ETHYL]BENZAMIDE HYDROCHLORIDE 95.00% | 135721-98-1 | 50MG | $1291.58 | 2021-12-16 | Buy |
4-FLUORO-N-[2-[4-(7-METHOXY-1-NAPHTHALENYL)-1-PIPERAZINYL]ETHYL]BENZAMIDE HYDROCHLORIDE Chemical Properties,Uses,Production
Uses
S 14506 is a full, highly potent and selective SR-1A agonist.
Definition
ChEBI: 4-fluoro-N-{2-[4-(7-methoxynaphthalen-1-yl)piperazin-1-yl]ethyl}benzamide hydrochloride is a hydrochloride salt that is obtained by reaction of 4-fluoro-N-{2-[4-(7-methoxynaphthalen-1-yl)piperazin-1-yl]ethyl}benzamide with one equivalent of hydrogen chloride. Highly potent selective 5-HT1A receptor full agonist (pKi values are 9.0, 6.6, 7.5, 6.6 and < 6.0 for 5-HT1A, 5-HT1B, 5-HT1C, 5-HT2 and 5-HT3 receptors respectively). Possibly binds between the agonist binding site and the G protein interaction switch site, affecting the activation mechanism, and may display positive cooperativity. Anxiolytic following central administration in vivo. It has a role as a serotonergic agonist and an anxiolytic drug. It contains a 4-fluoro-N-{2-[4-(7-methoxynaphthalen-1-yl)piperazin-1-yl]ethyl}benzamide(1+).
Biological Activity
Highly potent selective 5-HT 1A receptor full agonist (pK i values are 9.0, 6.6, 7.5, 6.6 and < 6.0 for 5-HT 1A , 5-HT 1B , 5-HT 1C , 5-HT 2 and 5-HT 3 receptors respectively). Possibly binds between the agonist binding site and the G protein interaction switch site, affecting the activation mechanism, and may display positive cooperativity. Anxiolytic following central administration in vivo .
4-FLUORO-N-[2-[4-(7-METHOXY-1-NAPHTHALENYL)-1-PIPERAZINYL]ETHYL]BENZAMIDE HYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
4-FLUORO-N-[2-[4-(7-METHOXY-1-NAPHTHALENYL)-1-PIPERAZINYL]ETHYL]BENZAMIDE HYDROCHLORIDE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
| SynAsst Chemical. | 021-60343070 | China | 12742 | 55 | |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8449 | 60 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing1@energy-chemical.com | China | 44843 | 58 |
| Supplier | Advantage |
|---|---|
| Alchem Pharmtech,Inc. | 58 |
| Aladdin Scientific | 58 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 69 |
| SynAsst Chemical. | 55 |
| EMMX Biotechnology LLC | 60 |
| Energy Chemical | 58 |