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1-(1-Naphthyl)piperazine hydrochloride

1-(1-Naphthyl)piperazine hydrochloride Structure
1-(1-Naphthyl)piperazine hydrochloride structure
CAS No.
104113-71-5
Chemical Name:
1-(1-Naphthyl)piperazine hydrochloride
Synonyms
NPPI;TIMTEC-BB SBB003161;1-(1-NAPHTHYL)PIPERAZINE;1-(1-Naphthalenyl)piperazine;1-(1-NAPHTHYL)PIPERAZINE HCL;1-(Piperazin-1-yl)naphthalene;1-(1-Naphthyl)piperazine*2HCl;1-(Naphth-1-yl)piperazine diHCl;1-(Naphthalen-1-yl)piperazineHCl;1-(1-Naphthyl)piperazine hydrochloride
CBNumber:
CB6244792
Molecular Formula:
C14H17ClN2
Molecular Weight:
248.75
MDL Number:
MFCD00055161
MOL File:
104113-71-5.mol
MSDS File:
SDS
Last updated:2026-09-12 18:54:07
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1-(1-Naphthyl)piperazine hydrochloride Properties

Melting point 235-237 °C
storage temp. Store at -20°C
solubility H2O: soluble
form needles
color white
InChI InChI=1S/C14H16N2.ClH/c1-2-6-13-12(4-1)5-3-7-14(13)16-10-8-15-9-11-16;/h1-7,15H,8-11H2;1H
InChIKey ZYVYPNZFOCZLEM-UHFFFAOYSA-N
SMILES C1(C=CC=C2C=CC=CC=12)N1CCNCC1.Cl

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P280a-P304+P340-P305+P351+P338-P405-P501a
WGK Germany  3
NFPA 704
0
2 0

1-(1-Naphthyl)piperazine hydrochloride price More Price(33)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 16150 1-(1-Naphthyl)piperazine (hydrochloride) ≥98% 104113-71-5 25mg $81 2026-04-30 Buy
Cayman Chemical 16150 1-(1-Naphthyl)piperazine (hydrochloride) ≥98% 104113-71-5 50mg $128 2026-04-30 Buy
Cayman Chemical 16150 1-(1-Naphthyl)piperazine (hydrochloride) ≥98% 104113-71-5 100mg $239 2026-04-30 Buy
Cayman Chemical 16150 1-(1-Naphthyl)piperazine (hydrochloride) ≥98% 104113-71-5 250mg $553 2026-04-30 Buy
Biosynth FN65693 1-(1-Naphthyl)piperazine hydrochloride 104113-71-5 50mg $150 2026-06-04 Buy
Product number Packaging Price Buy
16150 25mg $81 Buy
16150 50mg $128 Buy
16150 100mg $239 Buy
16150 250mg $553 Buy
FN65693 50mg $150 Buy

1-(1-Naphthyl)piperazine hydrochloride Chemical Properties, Uses, Production

Description

1-(1-Naphthyl)piperazine (1-NP) is a ligand for serotonin (5-hydroxytryptamine, 5-HT) receptors. It acts as an antagonist for 5-HT at 5-HT1 and 5-HT2 in rat cortical membranes with IC50 values of 6 and 1 nM, respectively. 1-NP also blocks contraction in the rat fundus induced by either 5-HT or tryptamine (IC50 = 1 nM for both agonists). 1-NP mimics the 5-HT1 agonist 1-(m-trifluoromethylphenyl)piperazine (TFMPP, ) in decreasing 5-HT receptor turnover and increasing serum corticosterone, suggesting that, in the absence of 5-HT, 1-NP may act as an agonist of the 5-HT1 receptor. However, in squirrel monkeys, 1-NP acts as a non-selective 5-HT receptor antagonist in altering operant behavior. 1-NP also binds to the human 5-HT6 receptor with an affinity comparable to that of 5-HT (Kis = 120 and 100 nM, respectively).

Uses

1-(1-Naphthyl)piperazinemiddotHCl is a mixed agonist/antagonist of the serotonin receptors.

in vitro

1-np binds to human 5- ht6 (h5-ht6) serotonin receptors with a ki of 120 nm [1]. in rat cortical membranes, 1-np inhibited the activity of 5-ht1 and 5-ht2 with ic50 values of 6 and 1 nm, respectively. 1-np also blocked contraction in the rat fundus induced by either 5-ht or tryptamine with an ic50 of 1 nm [3].

in vivo

in squirrel monkeys, 1-np (0.3–1.0 mg/kg) blocked the decrease of responding under fixed-interval (fi) schedules of presentation of food caused by dob (0.01–0.3 mg/kg), an agonist of 5-ht2. 1-np also antagonized the decreases in responding produced by quipazine (0.1–5.6 mg/kg), another agonist with predominant 5-ht2 actions [4].

IC 50

5-HT1A Receptor; 5-HT2A Receptor

References

[1] lee m, rangisetty j b, pullagurla m r, et al. 1-(1-naphthyl) piperazine as a novel template for 5-ht 6 serotonin receptor ligands[j]. bioorganic & medicinal chemistry letters, 2005, 15(6): 1707-1711.
[2] nichols d e, nichols c d. serotonin receptors[j]. chemical reviews, 2008, 108(5): 1614-1641.
[3] cohen m l, wittenauer l a. relationship between serotonin and tryptamine receptors in the rat stomach fundus[j]. journal of pharmacology and experimental therapeutics, 1985, 233(1): 75-79.
[4] mckearney j w. serotonin-antagonist effects of 1-(1-naphthyl) piperazine on operant behavior of squirrel monkeys[j]. neuropharmacology, 1989, 28(8): 817-821.

1-(1-Naphthyl)piperazine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

1-(1-Naphthyl)piperazine hydrochloride Suppliers

Global Suppliers ( 50)
Supplier Tel Email Country ProdList Advantage
Shanghai Latchem Co., Ltd. 021-61916491 15921747686 sales@latcheminc.com China 969 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Wuhan Chemwish Technology Co., Ltd 86-027-67849912 sales@chemwish.com China 35884 56
Nanjing Vital Chemical Co., Ltd. Please Send Email 18652950785 chemweiao@163.com China 4368 65
DebyeTec.com Inc. 18086626237 18086626237 2693528373@qq.com China 2907 56
BOC Sciences 16314854226 info@bocsci.com United States 9909 65
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9799 58
ChengDu TongChuangYuan Pharmaceutical Co.Ltd 028-83379370 13880556291 tcy@tcypharm.com China 8694 58
Nanjing Nohon Biological Technology Co., Ltd. 025-85767923 18512596075; sales@nuoxibio.com China 978 55
Nanjing Meihao Pharmaceutical Technology Co., Ltd. meitaochem@126.com meitaochem@126.com China 19087 58
Supplier Advantage
Shanghai Latchem Co., Ltd. 58
J & K SCIENTIFIC LTD. 76
Wuhan Chemwish Technology Co., Ltd 56
Nanjing Vital Chemical Co., Ltd. 65
DebyeTec.com Inc. 56
BOC Sciences 65
Shanghai EFE Biological Technology Co., Ltd. 58
ChengDu TongChuangYuan Pharmaceutical Co.Ltd 58
Nanjing Nohon Biological Technology Co., Ltd. 55
Nanjing Meihao Pharmaceutical Technology Co., Ltd. 58

View Latest Price from 1-(1-Naphthyl)piperazine hydrochloride manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
1-(1-Naphthyl) piperazine hydrochloride pictures 2026-04-22 1-(1-Naphthyl) piperazine hydrochloride
104113-71-5
 $31.00-81.00 98.80% 10g TargetMol Chemicals Inc.
1-(1-NAPHTHYL)PIPERAZINE HYDROCHLORIDE pictures 2020-02-19 1-(1-NAPHTHYL)PIPERAZINE HYDROCHLORIDE
104113-71-5
 $1.00 1KG 99% 200kgs Career Henan Chemical Co

1-(1-Naphthyl)piperazine hydrochloride Spectrum

1-(1-NAPHTHYL)PIPERAZINE HYDROCHLORIDE(104113-71-5)1HNMR

104113-71-5 (1-(1-Naphthyl)piperazine hydrochloride) Related Search:

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1-(1-NAPHTHYL)PIPERAZINE 1-(1-NAPHTHYL)PIPERAZINE HCL 1-(1-Naphthalenyl)piperazine 1-(Piperazin-1-yl)naphthalene 1-(Naphthalen-1-yl)piperazineHCl 1-(1-Naphthyl)piperazine*2HCl Piperazine, 1-(1-naphthalenyl)-, hydrochloride (1:1) TIMTEC-BB SBB003161 NPPI 1-NAPHTHALEN-1-YL-PIPERAZINE HYDROCHLORIDE 1-(Naphth-1-yl)piperazine diHCl Piperazine, 1-(1-naphthalenyl)-, monohydrochloride 1 (1 Naphthyl) piperazine hydrochloride,1(1Naphthyl) piperazine hydrochloride 1-(1-Naphthyl) piperazine hydrochloride, 10 mM in DMSO 1-(1-Naphthyl)piperazine hydrochloride 104113-71-5