1-(1-NAPHTHYL)PIPERAZINE HYDROCHLORIDE
- CAS No.
- 104113-71-5
- Chemical Name:
- 1-(1-NAPHTHYL)PIPERAZINE HYDROCHLORIDE
- Synonyms
- NPPI;TIMTEC-BB SBB003161;1-(1-NAPHTHYL)PIPERAZINE;1-(1-NAPHTHYL)PIPERAZINE HCL;1-(1-Naphthalenyl)piperazine;1-(Piperazin-1-yl)naphthalene;1-(1-Naphthyl)piperazine*2HCl;1-(Naphth-1-yl)piperazine diHCl;1-(Naphthalen-1-yl)piperazineHCl;1-(1-NAPHTHYL)PIPERAZINE HYDROCHLORIDE
- CBNumber:
- CB6244792
- Molecular Formula:
- C14H17ClN2
- Molecular Weight:
- 248.75
- MDL Number:
- MFCD00055161
- MOL File:
- 104113-71-5.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| WGK Germany | 3 | |||||||||
| NFPA 704 |
|
1-(1-NAPHTHYL)PIPERAZINE HYDROCHLORIDE price More Price(17)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Alfa Aesar | J62097 | 1-(1-Naphthyl)piperazine hydrochloride | 104113-71-5 | 1g | $276 | 2024-03-01 | Buy |
| Alfa Aesar | J62097 | 1-(1-Naphthyl)piperazine hydrochloride | 104113-71-5 | 5g | $661 | 2023-06-20 | Buy |
| Cayman Chemical | 16150 | 1-(1-Naphthyl) piperazine (hydrochloride) ≥98% | 104113-71-5 | 25mg | $73 | 2024-03-01 | Buy |
| Cayman Chemical | 16150 | 1-(1-Naphthyl) piperazine (hydrochloride) ≥98% | 104113-71-5 | 50mg | $116 | 2024-03-01 | Buy |
| Cayman Chemical | 16150 | 1-(1-Naphthyl) piperazine (hydrochloride) ≥98% | 104113-71-5 | 100mg | $217 | 2024-03-01 | Buy |
1-(1-NAPHTHYL)PIPERAZINE HYDROCHLORIDE Chemical Properties,Uses,Production
Description
1-(1-
Uses
1-(1-Naphthyl)piperazinemiddotHCl is a mixed agonist/antagonist of the serotonin receptors.
in vitro
1-np binds to human 5- ht6 (h5-ht6) serotonin receptors with a ki of 120 nm [1]. in rat cortical membranes, 1-np inhibited the activity of 5-ht1 and 5-ht2 with ic50 values of 6 and 1 nm, respectively. 1-np also blocked contraction in the rat fundus induced by either 5-ht or tryptamine with an ic50 of 1 nm [3].
in vivo
in squirrel monkeys, 1-np (0.3–1.0 mg/kg) blocked the decrease of responding under fixed-interval (fi) schedules of presentation of food caused by dob (0.01–0.3 mg/kg), an agonist of 5-ht2. 1-np also antagonized the decreases in responding produced by quipazine (0.1–5.6 mg/kg), another agonist with predominant 5-ht2 actions [4].
References
[1] lee m, rangisetty j b, pullagurla m r, et al. 1-(1-naphthyl) piperazine as a novel template for 5-ht 6 serotonin receptor ligands[j]. bioorganic & medicinal chemistry letters, 2005, 15(6): 1707-1711.
[2] nichols d e, nichols c d. serotonin receptors[j]. chemical reviews, 2008, 108(5): 1614-1641.
[3] cohen m l, wittenauer l a. relationship between serotonin and tryptamine receptors in the rat stomach fundus[j]. journal of pharmacology and experimental therapeutics, 1985, 233(1): 75-79.
[4] mckearney j w. serotonin-antagonist effects of 1-(1-naphthyl) piperazine on operant behavior of squirrel monkeys[j]. neuropharmacology, 1989, 28(8): 817-821.
1-(1-NAPHTHYL)PIPERAZINE HYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
1-(1-NAPHTHYL)PIPERAZINE HYDROCHLORIDE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10828 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 47465 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
| Nanjing Bicbiotechnology Co., Ltd | +86-2552131256 +86-18251840740 | sales@bicbiotech.com | China | 6000 | 58 |
| Shanghai Latchem Co., Ltd. | 021-61916491 15921747686 | sales@latcheminc.com | China | 996 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35906 | 56 |
| Nanjing Vital Chemical Co., Ltd. | Please Send Email 18652950785 | chemweiao@163.com | China | 4388 | 65 |
View Lastest Price from 1-(1-NAPHTHYL)PIPERAZINE HYDROCHLORIDE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2020-02-19 | 1-(1-NAPHTHYL)PIPERAZINE HYDROCHLORIDE
104113-71-5
|
US $1.00 / KG | 1KG | 99% | 200kgs | Career Henan Chemical Co |
-
- 1-(1-NAPHTHYL)PIPERAZINE HYDROCHLORIDE
104113-71-5
- US $1.00 / KG
- 99%
- Career Henan Chemical Co
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