4-(4-Fluorobenzoyl)butyric acid
- CAS No.
- 149437-76-3
- Chemical Name:
- 4-(4-Fluorobenzoyl)butyric acid
- Synonyms
- 4-(4-FLUOROPHENYL)BUTYRIC ACID;4-(4-FL;Ezetimibe-15;CAS:149437-76-3;CHEMBRDG-BB 4002813;TIMTEC-BB SBB000492;TIMTEC-BB SBB010216;4-(4-Fluorobenzoyl)b;Ezetimibe Impuriry P;4-(4-Fluorobenzoyl)butyric
- CBNumber:
- CB8168564
- Molecular Formula:
- C11H11FO3
- Molecular Weight:
- 210.2
- MDL Number:
- MFCD00667222
- MOL File:
- 149437-76-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 142-144°C |
|---|---|
| Boiling point | 394.6±22.0 °C(Predicted) |
| Density | 1.241±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMSO, Methanol |
| form | Solid |
| pka | 4.59±0.10(Predicted) |
| color | Off-White |
| InChI | InChI=1S/C11H11FO3/c12-9-6-4-8(5-7-9)10(13)2-1-3-11(14)15/h4-7H,1-3H2,(H,14,15) |
| InChIKey | ZBQROUOOMAMCQW-UHFFFAOYSA-N |
| SMILES | C(C1C=CC(F)=CC=1)(=O)CCCC(=O)O |
| CAS DataBase Reference | 149437-76-3(CAS DataBase Reference) |
| FDA UNII | Q9WD9HE8J3 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36-37 | |||||||||
| Hazard Note | Irritant | |||||||||
| HS Code | 29183000 | |||||||||
| NFPA 704 |
|
4-(4-Fluorobenzoyl)butyric acid price More Price(64)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | R169609 | 5-(4-FLUORO-PHENYL)-5-OXO-PENTANOIC ACID AldrichCPR | 149437-76-3 | 1 unit | $197 | 2026-04-30 | Buy |
| Sigma-Aldrich | R169609 | 5-(4-FLUORO-PHENYL)-5-OXO-PENTANOIC ACID Aldrich | 149437-76-3 | 50mg | $179 | 2024-03-01 | Buy |
| TCI Chemical | F0476 | 4-(4-Fluorobenzoyl)butyric Acid >98.0%(GC)(T) | 149437-76-3 | 1g | $31 | 2026-04-30 | Buy |
| TCI Chemical | F0476 | 4-(4-Fluorobenzoyl)butyric Acid >98.0%(GC)(T) | 149437-76-3 | 5g | $40 | 2026-04-30 | Buy |
| TRC | TRC-F588495-50MG | 4-Fluorophenyl-5’-oxobutyric Acid | 149437-76-3 | 50mg | $65 | 2026-06-03 | Buy |
4-(4-Fluorobenzoyl)butyric acid Chemical Properties, Uses, Production
Chemical Properties
Off-White Solid
Uses
4-Fluorophenyl-5’-oxobutyric Acid (cas# 149437-76-3) is a compound useful in organic synthesis.
Synthesis
108-55-4
462-06-6
149437-76-3
4-(4-Fluorobenzoyl)butyric acid was synthesized as follows: 250 g of anhydrous AlCl3 (1.87 mol) and 300 mL of fluorobenzene (307.5 g; 3.2 mol) were added to a 2 L three-necked round-bottomed flask, and the mixture was cooled to 5 °C in an ice bath. A turbid suspension of 100 g of glutaric anhydride (0.86 mol) dissolved in 400 mL of fluorobenzene (4.3 mol) was slowly added through the addition funnel over 45 min, keeping the reaction temperature below 12 °C. The reaction mixture was gradually warmed to room temperature and stirred for 90 min and the completion of the reaction was monitored by NMR. The reaction mixture was cooled to 0 to 5 °C and 700 mL of a cold aqueous solution of 1N HCl was carefully added to quench unreacted AlCl3, keeping the temperature below 20 °C initially and not exceeding 40 °C later. The mixture was poured into 2 L of a 1:1 mixture of water and ice (v/w) to precipitate the crude product, and the white suspension was filtered and washed well with water. The white solid was dissolved in 3 L of 5% NaHCO3 saturated aqueous solution, heated in a steam bath for 1 h and then filtered through a diatomaceous earth pad while hot. The filtrate was cooled to room temperature, adjusted to pH 1 by adding about 320 mL of concentrated HCl drop by drop, the product crystallized and stirred in an ice bath for 30 minutes. Filtered, the wet filter cake was washed with ice-cold water and dried under vacuum at 50 °C for 16 h. 143.2 g of 4-(4-fluorobenzoyl)butyric acid was obtained with a melting point of 141 to 142 °C and a yield of 79.3%.
References
[1] Patent: WO2004/99132, 2004, A2. Location in patent: Page 7-8
[2] Bioorganic and Medicinal Chemistry Letters, 2010, vol. 20, # 15, p. 4424 - 4426
[3] Patent: CN106397292, 2017, A. Location in patent: Paragraph 0053; 0083; 0084
[4] Patent: US2006/135755, 2006, A1. Location in patent: Page/Page column 15
[5] Patent: EP1137634, 2005, B1. Location in patent: Page/Page column 9
4-(4-Fluorobenzoyl)butyric acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Changzhou Huihan Biotechnology Co., Ltd. | 15380463325 15380463325 | 819573646@qq.com | China | 73 | 55 |
| Shanghai Arbor Chemical Co., Ltd. | 021-60451683 15021268886 | sales@arborchemical.com | China | 859 | 55 |
| Changzhou jinhan pharmaceutical technology co., LTD | 13917833665 | lyg@world-goldpharma.com | China | 144 | 58 |
| Hubei Changrun Biomedical Technology Co., Ltd. | 027-63496417 13007129042 | 3294393103@qq.com | China | 284 | 58 |
| Hubei Peien Biotechnology Co., Ltd. | 13127581762 13127581762 | peilingchem@sina.com | China | 499 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
View Latest Price from 4-(4-Fluorobenzoyl)butyric acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-30 | 4-(4-Fluorobenzoyl)butyric acid
149437-76-3
|
$5.00 | 1kg | ≥99% | 100mt/year | Jinan Finer Chemical Co., Ltd | |
 |
2026-06-08 | 4-(4-Fluorobenzoyl) butyric acid
149437-76-3
|
1kg | 99% | 1 | Jinan Ruitong Biotech Co., Ltd. | ||
 |
2026-03-20 | 4-(4-Fluorobenzoyl)butyric acid
149437-76-3
|
1kg | 99% | 100 mt | Hebei Chuanghai Biotechnology Co., Ltd |
-
- 4-(4-Fluorobenzoyl)butyric acid
149437-76-3
- $5.00
- ≥99%
- Jinan Finer Chemical Co., Ltd
-
- 4-(4-Fluorobenzoyl) butyric acid
149437-76-3
- 99%
- Jinan Ruitong Biotech Co., Ltd.
-
- 4-(4-Fluorobenzoyl)butyric acid
149437-76-3
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
