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Benzoyl peroxide

Acne vulgaris Active Ingredients for Acne Medications Mode of action Side effects as Acne Treatment Other Uses Benzoyl peroxide and Pregnancy References
Benzoyl peroxide
Benzoyl peroxide
CAS No.
94-36-0
Chemical Name:
Benzoyl peroxide
Synonyms
G20;BPO;Cadet;Garox;Topex;Xerac;Oxy 5;oxy-5;Oxy-L;BZF-60
CBNumber:
CB0484149
Molecular Formula:
C14H10O4
Formula Weight:
242.23
MOL File:
94-36-0.mol

Benzoyl peroxide Properties

Melting point:
105 °C(lit.)
Boiling point:
176°F
Density 
1.16 g/mL at 25 °C(lit.)
refractive index 
1.5430 (estimate)
Flash point:
>230 °F
storage temp. 
2-8°C
solubility 
0.35mg/l
form 
powder
color 
White
Water Solubility 
Insoluble
Merck 
14,1116
BRN 
984320
Stability:
Strong oxidizer. Highly flammable. Do not grind or subject to shock or friction. Incompatible with reducing agents, acids, bases, alcohols, metals, organic materials. Contact with combustible material, heating or friction may cause fire or explosion.
InChIKey
OMPJBNCRMGITSC-UHFFFAOYSA-N
CAS DataBase Reference
94-36-0(CAS DataBase Reference)
NIST Chemistry Reference
Benzoyl peroxide(94-36-0)
EPA Substance Registry System
Peroxide, dibenzoyl(94-36-0)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  O,Xn,N,Xi,E,T
Risk Statements  8-36/37/38-43-36-2-7-1-51/53-21/22-62-50-61-3-39/23/24/25-40
Safety Statements  53-17-26-36/37-45-60-36/37/39-3/7-14A-14-47-35-7-61-37/39-24
RIDADR  UN 3108 5.2
WGK Germany  2
RTECS  DM8575000
TSCA  Yes
HazardClass  5.2
PackingGroup  II
HS Code  29163200
Hazardous Substances Data 94-36-0(Hazardous Substances Data)
Symbol(GHS):
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H241 Heating may cause a fire or explosion Self-reactive substances and mixtures; and Organic peroxides Type B Danger P210, P220, P234, P280, P370+P378,P370+ P380+P375, P403+P235, P411,P420, P501
H242 Heating may cause a fire Self-reactive substances and mixtures; and Organic peroxides Type C, D,Type E, F
Type G
Danger
Warning
P210, P220, P234, P280, P370+P378,P403+P235, P411, P420, P501
H317 May cause an allergic skin reaction Sensitisation, Skin Category 1 Warning P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
H361 Suspected of damaging fertility or the unborn child Reproductive toxicity Category 2 Warning P201, P202, P281, P308+P313, P405,P501
H400 Very toxic to aquatic life Hazardous to the aquatic environment, acute hazard Category 1 Warning P273, P391, P501
H410 Very toxic to aquatic life with long lasting effects Hazardous to the aquatic environment, long-term hazard Category 1 Warning P273, P391, P501
Precautionary statements:
P201 Obtain special instructions before use.
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P220 Keep/Store away from clothing/…/combustible materials.
P234 Keep only in original container.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P271 Use only outdoors or in a well-ventilated area.
P272 Contaminated work clothing should not be allowed out of the workplace.
P273 Avoid release to the environment.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P391 Collect spillage. Hazardous to the aquatic environment
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P308+P313 IF exposed or concerned: Get medical advice/attention.
P333+P313 IF SKIN irritation or rash occurs: Get medical advice/attention.
P370+P378 In case of fire: Use … for extinction.
P405 Store locked up.
P410 Protect from sunlight.
P412 Do not expose to temperatures exceeding 50 oC/ 122 oF.
P420 Store away from other materials.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P410+P412 Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P501 Dispose of contents/container to..…

Benzoyl peroxide price More Price(18)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 179981 Benzoyl peroxide reagent grade, ≥98% 94-36-0 50g $38.6 2018-11-20 Buy
Sigma-Aldrich 179981 Benzoyl peroxide reagent grade, ≥98% 94-36-0 500g $107 2018-11-20 Buy
TCI Chemical B3152 Benzoyl Peroxide (wetted with ca. 25% Water) >75.0%(T) 94-36-0 25g $21 2018-11-22 Buy
Alfa Aesar L13174 Benzoyl peroxide, 97% (dry wt.), wet with 25% water 94-36-0 50g $18.7 2018-11-13 Buy
Alfa Aesar L13174 Benzoyl peroxide, 97% (dry wt.), wet with 25% water 94-36-0 250g $36.1 2018-11-13 Buy

Benzoyl peroxide Chemical Properties,Uses,Production

Acne vulgaris

Although the precise cause of acne is unclear, it appears to be associated with at least four factors: increased sebum production, follicular keratinisation, bacterial colonisation and inflammation.
Study suggests the prevalent bacterium implicated in the clinical course of acne is Propionibacterium acnes (P acnes), a gram-positive anaerobe that normally inhabits the skin and is implicated in the inflammatory phase of acne.
Benzoyl peroxide is mainly indicated in the treatment of mild to moderate acne and is often prescribed in conjunction with oral antibiotics (erythromycin or clindamycin) in the treatment of moderate to severe acne.

Active Ingredients for Acne Medications

Benzoyl peroxide used in 2.5, 5, and 10 percent concentrations, depending on the acne severity. Usually these are in a gel spreading agent, but they can also be in a cream base or a drying paste. Benzoyl peroxide is a keratolytic, which means “keratin-dissolving” and works by loosening dead cells stuck in the follicles. It also releases oxygen in the follicle. Because acne bacteria are anaerobic, they cannot survive in the presence of oxygen. Benzoyl peroxide essentially works both as an interfollicular exfoliant and as an antibacterial.

Mode of action

Benzoyl peroxide is lipophilic that can penetrate the stratum corneum and enter the pilosebaceous follicle. It is rapidly broken down to benzoic acid and hydrogen peroxide and generates free radicals that oxidise proteins in bacterial cell membranes, exerting a bactericidal action. In addition, it has shown that benzoyl peroxide can reduce the free fatty acid content of sebum, which provides a useful marker for bacterial activity. Benzoyl peroxide has an anti-inflammatory action and vitro studies suggest that this action arises from its ability to kill polymorphonuclear leukocytes (PMN cells) in the pilosebaceous follicles and so prevent their release of reactive oxygen species such as peroxides which enhance tissue inflammation. Involving equation about this process:
C6H5C(O)O-OC(O)C6H5 + H2O 2 C6H5COOH + ½ O2
Moreover, due to its irritant effect, benzoyl peroxide increases turnover rate of epithelial cells, thereby peeling the skin and promoting the resolution of comedones.

Side effects as Acne Treatment

Skin reactions such as peeling, itching, irritation, and reddened skin may occur, especially at the start of treatment. A very serious allergic reaction to this drug is rare. This medicine may be harmful if swallowed.

Other Uses


Benzoyl peroxide is used as a bleaching agent for certain foods, an oxidizing agent, a polymerizing initiator in the manufacture of plastics, a curing agent for silicone rubber, and an ingredient in various industrial processes.
Benzoyl peroxide, like most peroxides, is a powerful bleaching agent. It has a long history of use in the food industry as a bleaching agent added for flour, whey, and milk for cheese making. Contact with fabrics or hair can cause permanent color dampening almost immediately. Even secondary contact can cause bleaching.
Benzoyl peroxide is widely used as a catalyst in the polymerisation of molecules like styrene (phenylethene) to form polystyrene, which used to make many things from drinking cups to packaging material.

Benzoyl peroxide and Pregnancy

There are no studies looking at women who use topical benzoyl peroxide during pregnancy. When benzoyl peroxide is applied topically, only 5% is absorbed through the skin, and then it is completely metabolized to benzoic acid within the skin and excreted unchanged in the urine. It is not likely to increase risk for birth defects or cause problems for the baby. However, systemic effects on a pregnant woman and her child would not be expected and therefore use of this product during pregnancy would not be of concern.

References

https://medlineplus.gov/druginfo/meds/a601026.html
https://pubchem.ncbi.nlm.nih.gov/compound/benzoyl_peroxide#section=Drug-and-Medication-Information
http://www.chm.bris.ac.uk/motm/benzoyl-peroxide/benzoylh.htm
https://www.webmd.com/drugs/2/drug-1344/benzoyl-peroxide-topical/details
https://pubchem.ncbi.nlm.nih.gov/compound/benzoyl_peroxide#section=Top
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3114665/
https://mothertobaby.org/fact-sheets/topical-acne-treatments-pregnancy/pdf/

Chemical Properties

Benzoyl peroxide is an odorless, white or colorless crystalline powder.

Chemical Properties

white powder or crystals

Uses

vitamin B complex

Uses

Benzoyl Peroxide is a widely used organic compound of the peroxide family. Benzoyl Peroxide is often used in acne treatments , bleaching and polymerizing polyester and many other uses.

Uses

benzoyl peroxide is an antibacterial ingredient commonly used in acne treatments. It functions by forcing an oxidant (peroxide in this case) into the philosebaceous orifice where it releases oxygen, thereby diminishing the P. acnes population. This reduces the level of free fatty acids and skin infection. Benzoyl peroxide may cause skin irritation in people with sensitive skin.

Uses

Benzoyl Peroxide is a colorless, crystalline solid with a faint odor of benzaldehyde resulting from the interaction of benzoyl chloride and a cooled sodium peroxide solution. it is insoluble in water. it is used in specified cheeses at 0.0002% of milk level. it is used for the bleaching of flour, slowly decomposing to exert its full bleaching action, which results in whiter flour and bread.

Uses

Source of free radicals for industrial processes. Oxidizing agent in bleaching oils, flour, etc.; catalyst in the plastics industry; initiator in polymerization.

brand name

Acne-Aid Cream (Stiefel); Benoxyl (Stiefel); Benzac (Galderma); Benzac W (Galderma); Brevoxyl (Stiefel); Clear By Design (SmithKline Beecham); Dry and Clear (Whitehall-Robins); Epi-Clear (Bristol-Myers Squibb); Fostex BPO Bar, Gel, and Wash (Bristol-Myers Products); Loroxide (Dermik); PanOxyl (Stiefel); Persa-Gel (Ortho Pharmaceutical); Vanoxide (Dermik).

General Description

White, odorless powder, moderately toxic.

Air & Water Reactions

Insoluble in water.

Hazard

Highly toxic via inhalation. May explode spontaneously when dry (<1% of water). Never mix unless at least 33% water is present. Skin and upper respiratory tract irritant. Questionable carcinogen.

Contact allergens

Benzoyl peroxide is an oxidizing agent widely employed in acne topical therapy. It is also used as a polymerization catalyst of dental or industrial plastics and as a decolorizing agent of flours, oils, fats, and waxes. Irritant or allergic dermatitis may affect workers in the electronics and plastics (epoxy resins and catalysts) industries, electricians, ceramic workers, dentists and dental technicians, laboratory technicians, bakers, and acne patients. As it was contained in candles, it also induced contact dermatitis in a sacristan. Patch tests may be irritant.

Potential Exposure

Used as polymerization initiator, curing agent, and cross-linking agent.

First aid

If this chemical gets into the eyes, remove any contact lenses at once and irrigate immediately for at least 15 minutes, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts the skin, remove contaminated clothing and wash immediately with soap and water. Seek medical attention immediately. If this chemical has been inhaled, remove from exposure, begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR if heart action has stopped. Transfer promptly to a medical facility. When this chemical has been swallowed, get medical attention. Give large quantities of water and induce vomiting. Do not make an unconscious person vomit. Medical observation is recommended for 24 to 48 hours after breathing overexposure, as pulmonary edema may be delayed. As first aid for pulmonary edema, a doctor or authorized paramedic may consider administering a drug or other inhalation therapy.

Shipping

UN3104 : Organic peroxide type C, solid, Hazard Class: 5.2; Labels: 5.2—Organic peroxide, Technical Name Required. UN3108 : Organic peroxide type E, solid, Hazard Class: 5.2; Labels: 5.2—Organic peroxide, Technical

Purification Methods

Dissolve benzoyl peroxide in CHCl3 at room temperature and precipitate it by adding an equal volume of MeOH or pet ether. Similarly it is precipitated from acetone by adding two volumes of distilled water. It has also been crystallised from 50% MeOH and from diethyl ether. Dry it under vacuum at room temperature for 24hours. Store it in a desiccator in the dark at 0o. When purifying in the absence of water it can be EXPLOSIVE, and operations should be done on a very small scale with adequate protection. Large amounts should be kept moist with water and stored in a refrigerator. [Kim et al. J Org Chem 52 3691 1987, Beilstein 9 IV 777.]

Incompatibilities

May explode when heated above melting point, 103 C. A strong oxidizer. Extremely explosionsensitive to heat, shock, friction, and concussion. May explode or cause fire on contact with reducing agents; combustible substances, organic substances, wood, paper, metal powders, lithium aluminum hydride. Violent reaction with alcohols, organic and inorganic acids, and amines.

Waste Disposal

Pretreatment involves decomposition with sodium hydroxide. The final solution of sodium benzoate, which is very biodegradable, may be flushed into the drain. Disposal of large quantities of solution may require pH adjustment before release into the sewer or controlled incineration after mixing with a noncombustible material.

Benzoyl peroxide Preparation Products And Raw materials

Raw materials

Preparation Products


Benzoyl peroxide Suppliers

Global( 235)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
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Benzoyl peroxide Spectrum


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