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Oxolinic acid

Description References
Oxolinic acid
Oxolinic acid
Chemical Name:
Oxolinic acid
Molecular Formula:
Formula Weight:
MOL File:

Oxolinic acid Properties

Melting point:
314-316°C (dec.)
Boiling point:
1.3038 (rough estimate)
refractive index 
1.5500 (estimate)
Flash point:
storage temp. 
Soluble in 0.5N NaOH with warming
Crystalline Powder
Light Sensitive
Stable. Combustible.
CAS DataBase Reference
14698-29-4(CAS DataBase Reference)
EPA Substance Registry System
1,3-Dioxolo[4,5- g]quinoline-7-carboxylic acid, 5-ethyl-5,8-dihydro-8-oxo- (14698-29-4)
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xn
Risk Statements  22
Safety Statements  22-24/25-60-36
WGK Germany  3
RTECS  JI5075000
Hazardous Substances Data 14698-29-4(Hazardous Substances Data)
Toxicity LD50 in mice, rats (mg/kg): >6000, >2000 orally (Turner)
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P330 Rinse mouth.

Oxolinic acid price More Price(10)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 67126 Oxolinic acid analytical standard 14698-29-4 100mg $50.6 2017-11-08 Buy
Sigma-Aldrich O0240000 Oxolinic acid European Pharmacopoeia (EP) Reference Standard 14698-29-4 1EA $168 2017-11-08 Buy
Alfa Aesar J66637 Oxolinic acid, 98% 14698-29-4 25g $363 2017-11-08 Buy
Alfa Aesar J66637 Oxolinic acid, 98% 14698-29-4 5g $108 2017-11-08 Buy
Cayman Chemical 16789 Oxolinic Acid ≥98% 14698-29-4 5g $63 2017-11-08 Buy

Oxolinic acid Chemical Properties,Uses,Production


Developed in Japan in the 1970s, oxolinic acid belongs to the family of quinolone antibiotic, which is a synthetic antimicrobial agent aiming at gram-negative bacteria, especially those responsible for urinary tract infections. It is also commonly used in clinical for microbiological antimicrobial susceptibility tests against gram negative microbial isolates, providing antibiotic treatment options for infected patients. It can serve as a selective agent in several types of isolation media, for example, to isolate Gardnerella vaginalis. Besides, oxolinic acid can be applied in agriculture, which has proved to be effective against the seed-borne pathogen, such as Burkholderia glumae, a bacteria inducing grain rot, sheath rot, seedling rot, and bacterial panicle blight.
Oxolinic acid works by targeting DNA gyrase or topoisomerase II, enzymes vital for DNA synthesis, which ultimately inhibits DNA synthesis and cell division.


Chemical Properties

Crystalline Solid


Oxolinic acid is a quinolone antibiotic used for studies on DNA winding and coiling and for studies on dopaminergic neurotransmission processes. It is used to study new transmissible resistance mechanisms qnrA, qnrB, qnrS, and aac(6′)Ib-cr, in Escherichia


Quinolone antibacterial.


ChEBI: A quinolinemonocarboxylic acid having the carboxy group at position 7 as well as oxo and ethyl groups at positions 4 and 1 respectively and a dioxolo ring fused at the 5- and 6-positions. A synthetic antibiotic, it is used in veterinary medicine for the tr atment of bacterial infections in cattle, pigs and poultry.

Purification Methods

Purify the acid by recrystallisation from aqueous Me2CO, 95% EtOH or dimethylformamide. It has UV 220, (255.5sh), max 259.5, 268, (298sh, 311sh), 321 and 326nm [ 14.8, (36.8sh), 38.4, 38.4, (6.4sh, 9.2sh), 10.8 and 11.2 x 103]. [Kaminsky & Mettzer J Med Chem 11 160 1968, Beilstein 17 H 6, 17 I 3, 17 II 202, 17 III/IV 13, 17/1 V 11.]

Oxolinic acid Preparation Products And Raw materials

Raw materials

Preparation Products

Oxolinic acid Suppliers

Global( 163)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Hebei Guanlang Biotechnology Co., Ltd.
+86-0311-66562153 whatsapp +8615203118427
+86-0311-66562153 CHINA 418 50
Henan DaKen Chemical CO.,LTD.
+86-371-55531817 CHINA 22144 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693 CHINA 20803 55
Mainchem Co., Ltd.
+86-0592-6210733 CHINA 32765 55
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 China 1428 55
career henan chemical co
+86-371-86658258 CHINA 10012 58
Hubei Bangsun Chemical Co., Ltd. 18171081685
027-83219882 China 316 58
Hubei Yuancheng Saichuang Technology Co., Ltd. 18062666868/13048470578 QQ2355779403/2355880551
023-60363599,027-68886696,, China 5097 58
Foshan DaoQi Biological Co., Ltd. 15372409258
0571-87068629 China 2954 58
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
+86-10-82849933; China 96815 76

View Lastest Price from Oxolinic acid manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-08-15 Oxolinic acid
US $1.00 / KG 1G 98% 100KG
2018-08-07 Oxolinic acid
US $10.00 / KG 1KG 99% 100 MT per month -

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