methyl thieno[3,2-d][1,2,3]thiadiazole-6-carboxylate
![methyl thieno[3,2-d][1,2,3]thiadiazole-6-carboxylate Structure](CAS/20180711/GIF/152467-47-5.gif)
- CAS No.
- 152467-47-5
- Chemical Name:
- methyl thieno[3,2-d][1,2,3]thiadiazole-6-carboxylate
- Synonyms
- MTTC;methyl thieno[3,2-d]thiadiazole-6-carboxylate;methyl thieno[3,2-d][1,2,3]thiadiazole-6-carboxylate;Thieno[3,2-d][1,2,3]thiadiazole-6-carboxylic acid, methyl ester;2,3dihydrothienoThiadiazole Carboxylate,2,3 dihydrothieno Thiadiazole Carboxylate
- CBNumber:
- CB81992700
- Molecular Formula:
- C6H4N2O2S2
- Molecular Weight:
- 200.24
- MDL Number:
- MOL File:
- 152467-47-5.mol
methyl thieno[3,2-d][1,2,3]thiadiazole-6-carboxylate price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 10011048 | 2,3-dihydrothieno-Thiadiazole Carboxylate ≥98% | 152467-47-5 | 10mg | $16 | 2024-03-01 | Buy |
| Cayman Chemical | 10011048 | 2,3-dihydrothieno-Thiadiazole Carboxylate ≥98% | 152467-47-5 | 50mg | $63 | 2024-03-01 | Buy |
| Cayman Chemical | 10011048 | 2,3-dihydrothieno-Thiadiazole Carboxylate ≥98% | 152467-47-5 | 100mg | $109 | 2024-03-01 | Buy |
| ApexBio Technology | C4562 | 2,3-dihydrothieno-ThiadiazoleCarboxylate | 152467-47-5 | 100mg | $123 | 2021-12-16 | Buy |
| ApexBio Technology | C4562 | 2,3-dihydrothieno-ThiadiazoleCarboxylate | 152467-47-5 | 50mg | $69 | 2021-12-16 | Buy |
methyl thieno[3,2-d][1,2,3]thiadiazole-6-carboxylate Chemical Properties,Uses,Production
Description
1,2,3-
in vitro
as a 1,2,3-thiadiazole analog, 2,3-dihydrothieno-thiadiazole carboxylate could both inhibit and inactivate certain microsomal cyp450 enzymes (cyp2e1 and cyp2b4) at 100 μm, but not others (cyp1a2). moreover, p450 2e1 was significantly more sensitive than p450 2b4 to mechanism-based inactivation by 2,3-dihydrothieno-thiadiazole carboxylate when compared by the difference in partition numbers and inactivation rate constants. inactivation rate constants (kinact) determined from plots of 1/kobs versus 1/[i] were 0.08 for 2e1 and 0.04 min-1 for p450 2b4, with kis of 0.1 and 2.0 mm, respectively. the difference in the oxidation of the monocyclic and bicyclic thaidiazoles might account for the ability of 2,3-dihydrothieno-thiadiazole carboxylate to function as a mechanism-based inactivator [1].
References
[1] babu, b. r. and vaz, a.d.n. 1,2,3-thiadiazole: a novel heterocyclic heme ligand for the design of cytochrome p450 inhibitors. biochemistry 36, 7209-7216 (1997).
methyl thieno[3,2-d][1,2,3]thiadiazole-6-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
methyl thieno[3,2-d][1,2,3]thiadiazole-6-carboxylate Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Shanghai Raise Chemical Technology Co.,Ltd | 15026594951 | rs@raise-chem.com | China | 3204 | 55 |
| Xinyi Kaiwu Chemical Technology Co., Ltd. | 0516-0516-88997009 18651776937 | 4164357@qq.com | China | 2868 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8141 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24024 | 58 |
| Shanghai Haohong Scientific Co., Ltd. | 400-400-8210725 | malulu@leyan.com | China | 40041 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 8740 | 58 |
| ApexBio Technology | -- | sales@apexbt.com | United States | 6254 | 58 |