1-acetyl-5-bromoindolin-3-one
- CAS No.
- 106698-07-1
- Chemical Name:
- 1-acetyl-5-bromoindolin-3-one
- Synonyms
- 1-acetyl-5-bromoindolin-3-one;1-Acetyl-5-bromo-2H-indol-3-one;1-Acetyl-5-bromo-1,2-dihydro-3H-indol-3-one;3H-Indol-3-one, 1-acetyl-5-broMo-1,2-dihydro-
- CBNumber:
- CB82122131
- Molecular Formula:
- C10H8BrNO2
- Molecular Weight:
- 254.08
- MDL Number:
- MFCD00463385
- MOL File:
- 106698-07-1.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 1-Acetyl-5-bromoindolin-3-one | A168825 | 100mg | $65 |
| 1-Acetyl-5-bromoindolin-3-one | FA143708 | 250mg | $95 |
| 1-Acetyl-5-bromoindolin-3-one | FA143708 | 500mg | $165 |
| 1-acetyl-5-bromoindolin-3-one | X6517 | 500mg | $272 |
| 1-Acetyl-5-bromoindolin-3-one | FA143708 | 1g | $290 |
| More product size | |||
1-acetyl-5-bromoindolin-3-one price More Price(14)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | A168825 | 1-Acetyl-5-bromoindolin-3-one | 106698-07-1 | 100mg | $65 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FA143708 | 1-Acetyl-5-bromoindolin-3-one | 106698-07-1 | 250mg | $95 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FA143708 | 1-Acetyl-5-bromoindolin-3-one | 106698-07-1 | 500mg | $165 | 2021-12-16 | Buy |
| AK Scientific | X6517 | 1-acetyl-5-bromoindolin-3-one | 106698-07-1 | 500mg | $272 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FA143708 | 1-Acetyl-5-bromoindolin-3-one | 106698-07-1 | 1g | $290 | 2021-12-16 | Buy |
1-acetyl-5-bromoindolin-3-one Chemical Properties,Uses,Production
Uses
1-Acetyl-5-bromoindolin-3-one is a useful research intermediate used in the preparation of indole derivatives and analogs with 5-HT6 receptor antagonistic activity.
Synthesis
33588-54-4
106698-07-1
The general procedure for the synthesis of 1-acetyl-5-bromoindol-3-one from 5-bromohydroxyindolyl diacetate was as follows: 0.82 g (2.75 mmol) of 1-acetyl-5-bromoindolyl acetate was added to the reaction system in batches, maintaining the reaction temperature at 5 °C with continuous stirring, with reference to the method for the preparation of 1-acetyl-5-bromo-6-chloro-indol-3-ol. Subsequently, sulfuric acid (exact volume not specified) was slowly added. The reaction mixture was stirred at room temperature for 1 hour before being cooled in an ice-water bath and filtered, and the filter cake was washed with an ice-water solution of 1% sodium glacial acetic acid. The resulting greenish-blue product was lyophilized to give 0.67 g of solid product in 80% yield. Thin layer chromatography (TLC) analysis showed an Rf value of 0.2 (unfolding agent was cyclohexane:ethyl acetate=3:2). High resolution mass spectrometry (HRMS-ESI) analysis showed that the m/z calculated value of C10H10BrNO2 was 252.9738 and the measured value was 252.9727. Nuclear magnetic resonance hydrogen spectroscopy (1H NMR, 400MHz, CD3OD) data: δ 8.47 (d, 1H, J=8.8 Hz, H-7), 7.85 (d, 1H, J=2.0 Hz, H-4), 7.74 (dd, 1H, H-6), 5.29 (s, 1H, CH2), 2.38 (s, 3H, CH3). Nuclear magnetic resonance carbon spectroscopy (13C NMR, 100 MHz, CD3OD) data: δ 192.7 (C-3), 167.6 (C=O), 151.9 (C-8), 139.3 (C-6), 138.9, 125.8 (C-4), 119.7 (C-7), 116.8, 114.0, 55.7 (CH2), 23.6 ( CH3).
References
[1] Organic and Biomolecular Chemistry, 2004, vol. 2, # 7, p. 981 - 988
[2] Carbohydrate Research, 2015, vol. 402, p. 50 - 55
[3] Russian Journal of Organic Chemistry, 1998, vol. 34, # 4, p. 570 - 582
[4] Bioorganic and Medicinal Chemistry Letters, 2011, vol. 21, # 1, p. 346 - 349
[5] Tetrahedron Letters, 2016, vol. 57, # 49, p. 5493 - 5496
1-acetyl-5-bromoindolin-3-one Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29735 | 60 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10821 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29798 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +86-18621343501; +undefined18621343501 | product@acmec-e.com | China | 33337 | 58 |
| SHANGHAI KEAN TECHNOLOGY CO., LTD. | +8613817748580 | cooperation@kean-chem.com | China | 40066 | 58 |
| DAYANG CHEM (HANGZHOU) CO.,LTD | +86-88938639 +86-17705817739 | info@dycnchem.com | China | 53899 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532; 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| ChemFuture PharmaTech (Jiangsu) Ltd | 5108538618 | suger.wang@chemfuture.com | China | 832 | 65 |
View Lastest Price from 1-acetyl-5-bromoindolin-3-one manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2020-01-14 | 1-acetyl-5-bromoindolin-3-one
106698-07-1
|
US $9.80 / KG | 1g | ≥99% | 100kg | Career Henan Chemical Co |
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- 1-acetyl-5-bromoindolin-3-one
106698-07-1
- US $9.80 / KG
- ≥99%
- Career Henan Chemical Co
