INDIRUBIN-3'-MONOXIME-5-SULPHONIC ACID

Uses

Indirubin-3'-monoxime-5-sulphonic acid is a potent and selective inhibitor of CDK1, CDK5, and GSK-3β with IC50s of 5 nM, 7 nM, and 80 nM, respectively[1].

Biological Activity

Cell permeable: no', 'Primary Target
CDK1', 'Product competes with ATP.', 'Reversible: yes', 'Target IC50: 5 nM, 7 nM, 80 nM, against Cdk1, Cdk5, and glycogen synthase kinase-3β (GSK-3β), respectively

IC 50

CDK1: 5 nM (IC₅₀); CDK5: 7 nM (IC₅₀); GSK-3β: 80 nM (IC₅₀)

References

[1] Leclerc S, et al. Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors. J Biol Chem. 2001 Jan 5;276(1):251-60. DOI:10.1074/jbc.M002466200

Raw materials

Preparation Products