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2-Phenoxybenzoicacid-[(5-methyl-2-furanyl)methylene]hydrazide

CAS No.
113906-27-7
Chemical Name:
2-Phenoxybenzoicacid-[(5-methyl-2-furanyl)methylene]hydrazide
Synonyms
CS-2563;PNU 74654;PNU74654; PNU 74654;N'-((5-Methylfuran-2-yl)methylene)-2-phenoxybenzohydrazide;N'-((5-Methylfuran-2-yl)methylene)-2-phenoxybenzohydrazide;2-Phenoxybenzoicacid-[(5-methyl-2-furanyl)methylene]hydrazide;Benzoic acid, 2-phenoxy-, 2-[(5-methyl-2-furanyl)methylene]hydrazide;PNU 74654,2-Phenoxybenzoicacid-[(5-methyl-2-furanyl)methylene]hydrazide
CBNumber:
CB82518792
Molecular Formula:
C19H16N2O3
Molecular Weight:
320.34
MDL Number:
MFCD12912438
MOL File:
113906-27-7.mol
Last updated:2023-06-30 15:45:59

2-Phenoxybenzoicacid-[(5-methyl-2-furanyl)methylene]hydrazide Properties

Density 1.17±0.1 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO: >10mg/mL
pka 12.12±0.46(Predicted)
form solid
color white to off-white
Stability Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P264-P270-P301+P312-P501
Hazard Codes  Xn
Risk Statements  22
WGK Germany  3
NFPA 704
0
2 0

2-Phenoxybenzoicacid-[(5-methyl-2-furanyl)methylene]hydrazide price More Price(31)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich P0052 PNU-74654 ≥98% (HPLC), solid 113906-27-7 5mg $142 2024-03-01 Buy
Sigma-Aldrich P0052 PNU-74654 ≥98% (HPLC), solid 113906-27-7 25mg $557 2024-03-01 Buy
Cayman Chemical 16349 PNU 74654 ≥98% 113906-27-7 1mg $36 2024-03-01 Buy
Cayman Chemical 16349 PNU 74654 ≥98% 113906-27-7 5mg $70 2024-03-01 Buy
Cayman Chemical 16349 PNU 74654 ≥98% 113906-27-7 10mg $120 2024-03-01 Buy
Product number Packaging Price Buy
P0052 5mg $142 Buy
P0052 25mg $557 Buy
16349 1mg $36 Buy
16349 5mg $70 Buy
16349 10mg $120 Buy

2-Phenoxybenzoicacid-[(5-methyl-2-furanyl)methylene]hydrazide Chemical Properties,Uses,Production

Description

PNU 75654 (113906-27-7) disrupts the Wnt signaling pathway via inhibition of the interaction (KD50?= 450 nM) between β-catenin and T cell factor 4 (Tcf4).

Uses

PNU 74654 is a β-catenin inhibitor which inhibits interactions between β-catenin and transcription factor T-cell factor 4 (Tcf4) thus disrupting the Wnt signal transduction pathway.

Uses

PNU-74654 has been used:

  • as a β-catenin signaling inhibitor to study its effects on the funnel cartilage differentiation in Sepia sp. embryos
  • as a Wnt signaling inhibitor to study its effects on glycogen synthase kinase 3β (GSK-3β) inhibition in prostate cancer cell lines
  • as a Wnt signaling inhibitor to study its effects on leptin-induced cell proliferation in breast cancer cells

Biochem/physiol Actions

PNU-74654 inhibits the Wnt-β catenin pathway by blocking the interaction between β-catenin and TCF (T cell factor). PNU-74654 is also an anti-tumor agent. Aberrant activation of the Wnt/β-catenin pathway (canonical pathway) is implicated in driving development/progression of different tumors, such as colon cancer, through interaction between β-catenin and T cell factor (TCF), which regulates the expression of target genes in cell proliferation and differentiation. Inhibition of this pathway activity in cancer cell lines efficiently blocks their growth. PNU-74654 inhibits this pathway by blocking the interaction between β-catenin and TCF.

storage

+4°C

References

1) Trosset?et al. (2006)?Inhibition of protein-protein interactions: the discovery of druglike beta-catenin inhibitors by combining virtual and biophysical screening; Proteins,?64?60

2-Phenoxybenzoicacid-[(5-methyl-2-furanyl)methylene]hydrazide Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 104)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795 ivan@atkchemical.com China 32836 60
HANGZHOU CLAP TECHNOLOGY CO.,LTD
86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6313 58
InvivoChem
+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6393 58
Hangzhou MolCore BioPharmatech Co.,Ltd.
+86-057181025280; +8617767106207 sales@molcore.com China 49739 58
TargetMol Chemicals Inc.
+1-781-999-5354 support@targetmol.com United States 19973 58
Aladdin Scientific
+1-+1(833)-552-7181 sales@aladdinsci.com United States 57511 58
3B Pharmachem (Wuhan) International Co.,Ltd. 821-50328103-801 18930552037 3bsc@sina.com China 15848 69
Dalian Meilun Biotech Co., Ltd. 0411-62910999 13889544652 meilunui@163.com China 4672 58
Wuhan Synchallenge Unipharm Inc.,Ltd +86-027-87166955 wangjohnzen@hotmail.com wangjohnzen@gmail.com China 31 58
Zhengzhou HSH Science & Technology Co., Ltd. 0371-55932928 18937192232 1282296214@qq.com China 498 55

2-Phenoxybenzoicacid-[(5-methyl-2-furanyl)methylene]hydrazide Spectrum

2-Phenoxybenzoicacid-[(5-methyl-2-furanyl)methylene]hydrazide PNU 74654 Benzoic acid, 2-phenoxy-, 2-[(5-methyl-2-furanyl)methylene]hydrazide PNU 74654,2-Phenoxybenzoicacid-[(5-methyl-2-furanyl)methylene]hydrazide PNU74654; PNU 74654 CS-2563 N'-((5-Methylfuran-2-yl)methylene)-2-phenoxybenzohydrazide N'-((5-Methylfuran-2-yl)methylene)-2-phenoxybenzohydrazide 113906-27-7