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N-[[(3-Chloro-2-hydroxy-5-nitrophenyl)amino]thioxomethyl]benzamide

CAS No.
53501-41-0
Chemical Name:
N-[[(3-Chloro-2-hydroxy-5-nitrophenyl)amino]thioxomethyl]benzamide
Synonyms
PIT 1;N-((3-Chloro-2-hydroxy-5-nitrophenyl)carbamothioyl)benzamide;N-[[(3-Chloro-2-hydroxy-5-nitrophenyl)amino]thioxomethyl]benzamide;Benzamide, N-[[(3-chloro-2-hydroxy-5-nitrophenyl)amino]thioxomethyl]-
CBNumber:
CB82518929
Molecular Formula:
C14H10ClN3O4S
Molecular Weight:
351.76
MDL Number:
MFCD00761149
MOL File:
53501-41-0.mol
Last updated:2023-07-14 17:28:52

N-[[(3-Chloro-2-hydroxy-5-nitrophenyl)amino]thioxomethyl]benzamide Properties

Density 1.592
storage temp. Store at +4°C
solubility DMSO: ≥14mg/mL
form powder
pka 4.44±0.50(Predicted)
color white to tan
Stability Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS07,GHS09
Signal word  Warning
Hazard statements  H302-H400
Precautionary statements  P273-P301+P312+P330
Hazard Codes  Xn,N
Risk Statements  22-50
Safety Statements  61
RIDADR  UN 3077 9 / PGIII
WGK Germany  3
NFPA 704
0
2 0

N-[[(3-Chloro-2-hydroxy-5-nitrophenyl)amino]thioxomethyl]benzamide price More Price(14)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML0122 Pit-1 ≥98% (HPLC) 53501-41-0 5mg $97.9 2024-03-01 Buy
Sigma-Aldrich SML0122 Pit-1 ≥98% (HPLC) 53501-41-0 25mg $388 2024-03-01 Buy
Cayman Chemical 10728 PIT-1 ≥98% 53501-41-0 5mg $20 2024-03-01 Buy
Cayman Chemical 10728 PIT-1 ≥98% 53501-41-0 10mg $37 2024-03-01 Buy
Cayman Chemical 10728 PIT-1 ≥98% 53501-41-0 50mg $146 2024-03-01 Buy
Product number Packaging Price Buy
SML0122 5mg $97.9 Buy
SML0122 25mg $388 Buy
10728 5mg $20 Buy
10728 10mg $37 Buy
10728 50mg $146 Buy

N-[[(3-Chloro-2-hydroxy-5-nitrophenyl)amino]thioxomethyl]benzamide Chemical Properties,Uses,Production

Description

PtdIns-(3,4,5)-P3 (PIP3) serves as an anchor for the binding of signal transduction proteins bearing pleckstrin homology (PH) domains such as phosphatidylinositol 3-kinase (PI3K) or PTEN. Protein binding to PIP3 is important for cytoskeletal rearrangement and membrane trafficking and initiates an intricate signaling cascade that has been implicated in cancer. PIT-1 is a selective nonphosphoinositide inhibitor that specifically disrupts PIP3/Akt PH domain binding with an IC50 value of 31 μM. PIT-1 suppresses PI3K-PDK1-Akt-dependent phosphorylation, which has been shown to reduce cell viability and induce apoptosis in PTEN-deficient U87MG glioblastoma cells (IC50 = 37 μM).

Uses

PIT 1 is an apoptosis inducing selective PIP3 antagonist.

References

1) Maio?et al.?(2010),?Small molecule inhibition of phosphatidylinositol-3,4,5-triphosphate (PI3) binding to pleckstrin homology domains; Proc. Natl. Acad. Sci. USA,?107?20126 2) McNamare and Degterev?(2011),?Small-molecule inhibitor of the PI3K signaling network; Future Med. Chem.,?3?549

N-[[(3-Chloro-2-hydroxy-5-nitrophenyl)amino]thioxomethyl]benzamide Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 57)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795 ivan@atkchemical.com China 32480 60
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
Aladdin Scientific
+1-833-552-7181 sales@aladdinsci.com United States 57511 58
Shanghai Boyle Chemical Co., Ltd. 021-50182298 021-50180596 sales@boylechem.com China 2210 55
3B Pharmachem (Wuhan) International Co.,Ltd. 821-50328103-801 18930552037 3bsc@sina.com China 15848 69
BOC Sciences 1-631-485-4226; 16314854226 info@bocsci.com United States 14059 65
EMMX Biotechnology LLC 888-539-0666 info@emmx.com United States 8449 60
MQ (shanghai) Pharmaceuticals Co., Ltd. 13761635123 1014988033@qq.com China 4979 55
Amatek Scientific Co. Ltd. 0512-56316828 info@amateksci.com China 28822 58
Angel Pharmatech, Ltd. 17317130613 3358272972@qq.com China 3237 58

53501-41-0(N-[[(3-Chloro-2-hydroxy-5-nitrophenyl)amino]thioxomethyl]benzamide)Related Search:

N-[[(3-Chloro-2-hydroxy-5-nitrophenyl)amino]thioxomethyl]benzamide PIT 1 Benzamide, N-[[(3-chloro-2-hydroxy-5-nitrophenyl)amino]thioxomethyl]- N-((3-Chloro-2-hydroxy-5-nitrophenyl)carbamothioyl)benzamide 53501-41-0 C14H10ClN3O4S