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ChemicalBook >> CAS DataBase List >>2-{4-[4-Pyridin-4-yl-1-(2,2,2-trifluoro-ethyl)-1H-pyrazol-3-yl]-phenoxymethyl}-quinoline

2-{4-[4-Pyridin-4-yl-1-(2,2,2-trifluoro-ethyl)-1H-pyrazol-3-yl]-phenoxymethyl}-quinoline

2-{4-[4-Pyridin-4-yl-1-(2,2,2-trifluoro-ethyl)-1H-pyrazol-3-yl]-phenoxymethyl}-quinoline Structure
2-{4-[4-Pyridin-4-yl-1-(2,2,2-trifluoro-ethyl)-1H-pyrazol-3-yl]-phenoxymethyl}-quinoline structure
CAS No.
898563-00-3
Chemical Name:
2-{4-[4-Pyridin-4-yl-1-(2,2,2-trifluoro-ethyl)-1H-pyrazol-3-yl]-phenoxymethyl}-quinoline
Synonyms
TP-10;2-[[4-[4-pyridin-4-yl-1-(2,2,2-trifluoroethyl)pyrazol-3-yl]phenoxy]methyl]quinoline;2-{4-[4-Pyridin-4-yl-1-(2,2,2-trifluoro-ethyl)-1H-pyrazol-3-yl]-phenoxymethyl}-quinoline;2-({4-[4-(4-Pyridinyl)-1-(2,2,2-trifluoroethyl)-1H-pyrazol-3-yl]p henoxy}methyl)quinoline;Quinoline, 2-[[4-[4-(4-pyridinyl)-1-(2,2,2-trifluoroethyl)-1H-pyrazol-3-yl]phenoxy]methyl]-;schizophrenia,U-87 MG,TP 10,cGMP,TP10,inhibit,TP-10,disorder,Inhibitor,cAMP,reactive oxygen,Phosphodiesterase (PDE),pCREB-LI
CBNumber:
CB82535186
Molecular Formula:
C26H19F3N4O
Molecular Weight:
460.45
MDL Number:
MOL File:
898563-00-3.mol
Last updated:2023-07-14 17:44:29
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2-{4-[4-Pyridin-4-yl-1-(2,2,2-trifluoro-ethyl)-1H-pyrazol-3-yl]-phenoxymethyl}-quinoline Properties

Boiling point 564.4±50.0 °C(Predicted)
Density 1.30±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO : ≥ 100 mg/mL (217.18 mM);Water : < 0.1 mg/mL (insoluble)
pka 4.08±0.10(Predicted)

2-{4-[4-Pyridin-4-yl-1-(2,2,2-trifluoro-ethyl)-1H-pyrazol-3-yl]-phenoxymethyl}-quinoline price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-5242 TP-10 98.54% 898563-00-3 5mg $420 2021-12-16 Buy
American Custom Chemicals Corporation HCH0316639 TP-10 95.00% 898563-00-3 5MG $499.36 2021-12-16 Buy
ChemScene CS-5242 TP-10 98.54% 898563-00-3 10mg $600 2021-12-16 Buy
ChemScene CS-5242 TP-10 98.54% 898563-00-3 50mg $1800 2021-12-16 Buy
ChemScene CS-5242 TP-10 98.54% 898563-00-3 100mg $2520 2021-12-16 Buy
Product number Packaging Price Buy
CS-5242 5mg $420 Buy
HCH0316639 5MG $499.36 Buy
CS-5242 10mg $600 Buy
CS-5242 50mg $1800 Buy
CS-5242 100mg $2520 Buy

2-{4-[4-Pyridin-4-yl-1-(2,2,2-trifluoro-ethyl)-1H-pyrazol-3-yl]-phenoxymethyl}-quinoline Chemical Properties,Uses,Production

Description

TP-10 is a PDE10A inhibitor with IC50 of 0.8 nM.IC50 value: 0.8 nM [1]Target: PDE10ATP-10 has extremely potent PDE10A inhibitory activity and highselectivity against other PDEs, and be active in the mouse behavioral model for positive symptoms. TP-10 demonstrats good in vitro and in vivo activity, the intrinsic clearance (CLint) of these compounds in mouse liver microsomes (MLM) was extremely high in assay (CLint>1000 mL/min/kg). [1]

References

[1]. Hamaguchi W, et al. Synthesis and in vivo evaluation of novel quinoline derivatives as phosphodiesterase 10A inhibitors. Chem Pharm Bull (Tokyo). 2014;62(12):1200-1213. [2]. Verhoest PR, et al. Discovery of a novel class of phosphodiesterase 10A inhibitors and identification of clinical candidate 2-[4-(1-methyl-4-pyridin-4-yl-1H-pyrazol-3-yl)-phenoxymethyl]-quinoline (PF-2545920) for the treatment of schizophrenia. J Med Chem

2-{4-[4-Pyridin-4-yl-1-(2,2,2-trifluoro-ethyl)-1H-pyrazol-3-yl]-phenoxymethyl}-quinoline Preparation Products And Raw materials

Raw materials

Preparation Products

2-{4-[4-Pyridin-4-yl-1-(2,2,2-trifluoro-ethyl)-1H-pyrazol-3-yl]-phenoxymethyl}-quinoline Suppliers

Global( 26)Suppliers
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BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19553 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
Career Henan Chemica Co 		+86-0371-86658258 15093356674; laboratory@coreychem.com China 30255 58
Wuhan Topule Biopharmaceutical Co., Ltd 		+8618327326525 masar@topule.com China 8474 58
Amadis Chemical Company Limited 		571-89925085 sales@amadischem.com China 131981 58
Beijing Yisiyan Technology Research Center 010-56645598 13366904824 bjkaida@163.com China 1666 59
MedChemexpress LLC 021-58955995 sales@medchemexpress.cn United States 4863 58
Musechem +1-800-259-7612 info@musechem.com United States 4662 60
Shenzhen Regent Biochemical Technology Co., Ltd. 0755-0755-85201366 18938635012 sales@regentsciences.com China 9293 58
Beijing xinyanhui pharmaceutical research and development co., LTD 13969155946 1461866103@qq.com China 16111 58
Supplier Advantage
BOC Sciences 		58
TargetMol Chemicals Inc. 		58
Career Henan Chemica Co 		58
Wuhan Topule Biopharmaceutical Co., Ltd 		58
Amadis Chemical Company Limited 		58
Beijing Yisiyan Technology Research Center 59
MedChemexpress LLC 58
Musechem 60
Shenzhen Regent Biochemical Technology Co., Ltd. 58
Beijing xinyanhui pharmaceutical research and development co., LTD 58
2-{4-[4-Pyridin-4-yl-1-(2,2,2-trifluoro-ethyl)-1H-pyrazol-3-yl]-phenoxymethyl}-quinoline TP-10 2-[[4-[4-pyridin-4-yl-1-(2,2,2-trifluoroethyl)pyrazol-3-yl]phenoxy]methyl]quinoline Quinoline, 2-[[4-[4-(4-pyridinyl)-1-(2,2,2-trifluoroethyl)-1H-pyrazol-3-yl]phenoxy]methyl]- 2-({4-[4-(4-Pyridinyl)-1-(2,2,2-trifluoroethyl)-1H-pyrazol-3-yl]p henoxy}methyl)quinoline schizophrenia,U-87 MG,TP 10,cGMP,TP10,inhibit,TP-10,disorder,Inhibitor,cAMP,reactive oxygen,Phosphodiesterase (PDE),pCREB-LI 898563-00-3