ChemicalBook >> CAS DataBase List >>SBE 13 hydrochloride
SBE 13 hydrochloride
- CAS No.
- 1052532-15-6
- Chemical Name:
- SBE 13 hydrochloride
- Synonyms
- CS-1632;SBE-13 HCl;SBE13 HydrochL;SBE 13 hydrochloride;SBE 13 hydrochloride USP/EP/BP;SBE 13 hydrochloride >=98% (HPLC);N-(4-((6-chloropyridin-3-yl)methoxy)-3-methoxybenzyl)-2-(3,4-dimethoxyphenyl)ethanamine;N-(4-((6-Chloro-3-pyridinyl)methoxy)-3-methoxybenzyl)-N-(2-(3,4-dimethoxyphenyl)ethyl)amine;N-(4-((6-chloropyridin-3-yl)Methoxy)-3-Methoxybenzyl)-2-(3,4-diMethoxyphenyl)ethanaMine hydrochloride;N-[[4-[(6-Chloro-3-pyridinyl)methoxy]-3-methoxyphenyl]methyl]-3,4-dimethoxy-benzeneethanamine hydrochloride
- CBNumber:
- CB82552606
- Molecular Formula:
- C24H28Cl2N2O4
- Molecular Weight:
- 479.4
- MDL Number:
- MFCD20036266
- MOL File:
- 1052532-15-6.mol
Last updated:2023-06-08 09:02:49
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P280-P305+P351+P338 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22 | |||||||||
| WGK Germany | 3 | |||||||||
| NFPA 704 |
|
SBE 13 hydrochloride price More Price(21)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0012 | SBE 13 hydrochloride ≥98% (HPLC) | 1052532-15-6 | 5mg | $118 | 2022-05-15 | Buy |
| Cayman Chemical | 21241 | SBE 13 (hydrochloride) ≥98% | 1052532-15-6 | 5mg | $86 | 2024-03-01 | Buy |
| Cayman Chemical | 21241 | SBE 13 (hydrochloride) ≥98% | 1052532-15-6 | 10mg | $111 | 2024-03-01 | Buy |
| Cayman Chemical | 21241 | SBE 13 (hydrochloride) ≥98% | 1052532-15-6 | 25mg | $232 | 2024-03-01 | Buy |
| Cayman Chemical | 21241 | SBE 13 (hydrochloride) ≥98% | 1052532-15-6 | 50mg | $421 | 2024-03-01 | Buy |
SBE 13 hydrochloride Chemical Properties,Uses,Production
Description
SBE 13 is a potent inhibitor of polo-like kinase 1 (Plk1) (IC50 = 0.2 nM) that targets the inactive conformation of the enzyme . It exhibits no activity against aurora A kinase and less effectively inhibits Plk2 (IC50 > 66 μM) and Plk3 (IC50 = 875 nM). SBE 13 induces cell cycle arrest, reduces cell proliferation (EC50 = 5-60 μM), and induces apoptosis in a broad range of human cancer cell lines.
Uses
SBE13 Hydrochloride is a selective inhibitor of PLK1.
in vitro
to determine its ability to induce cell death in cancer cells, we applied kinase assays, western blot analyses, facs can analyses, caspase assays and immunofluorescence studies. we detected decreased cell proliferation, delayed progression through the cell cycle in lower sbe13 concentrations, a g2/m arrest using higher sbe13 concentrations followed by apoptosis, and abnormal mitotic figures. notably, sbe13 did not influence activity of other kinases (plk2, plk3, aurora a), indicating the selectivity of this type ii plk1 inhibitor [1].
SBE 13 hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 74)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3012 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32715 | 60 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | contact@trustwe.com | China | 5738 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 27486 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Coresyn Pharmatech Co., Ltd. | +86-571-86626709 +86-18157142896 | cbc@coresyn.com | China | 9991 | 58 |
View Lastest Price from SBE 13 hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
![N-[[4-[(6-chloropyridin-3-yl)methoxy]-3-methoxyphenyl]methyl]-2-(3,4-dimethoxyphenyl)ethanamine,hydrochloride pictures](https://img.chemicalbook.com/ProductImageEN/2019-12/Small/6071f2ba-f93d-486f-9cdb-74f52151c90f.png) |
2019-12-24 | N-[[4-[(6-chloropyridin-3-yl)methoxy]-3-methoxyphenyl]methyl]-2-(3,4-dimethoxyphenyl)ethanamine,hydrochloride
1052532-15-6
|
US $1.00 / KG | 1KG | Min98% HPLC | g/kg/ton | Career Henan Chemical Co |
-
- N-[[4-[(6-chloropyridin-3-yl)methoxy]-3-methoxyphenyl]methyl]-2-(3,4-dimethoxyphenyl)ethanamine,hydrochloride
1052532-15-6
- US $1.00 / KG
- Min98% HPLC
- Career Henan Chemical Co
1052532-15-6(SBE 13 hydrochloride)Related Search:
SBE 13 hydrochloride
N-(4-((6-chloropyridin-3-yl)Methoxy)-3-Methoxybenzyl)-2-(3,4-diMethoxyphenyl)ethanaMine hydrochloride
SBE-13 HCl
N-(4-((6-Chloro-3-pyridinyl)methoxy)-3-methoxybenzyl)-N-(2-(3,4-dimethoxyphenyl)ethyl)amine
N-[[4-[(6-Chloro-3-pyridinyl)methoxy]-3-methoxyphenyl]methyl]-3,4-dimethoxy-benzeneethanamine hydrochloride
CS-1632
SBE13 HydrochL
SBE 13 hydrochloride >=98% (HPLC)
SBE 13 hydrochloride USP/EP/BP
N-(4-((6-chloropyridin-3-yl)methoxy)-3-methoxybenzyl)-2-(3,4-dimethoxyphenyl)ethanamine
Inhibitor,SBE13,Apoptosis,Polo-like Kinase (PLK),inhibit,SBE13 Hydrochloride,SBE 13,SBE-13 Hydrochloride,Autophagy,SBE-13
1052532-15-6
C24H27ClN2O4HCl
Inhibitors