ChemicalBook >> CAS DataBase List >>1-((S)-2-(dimethylamino)-3-(4-hydroxyphenyl)propyl)-3-((S)-1-(thiophen-3-yl)propan-2-yl)urea
1-((S)-2-(dimethylamino)-3-(4-hydroxyphenyl)propyl)-3-((S)-1-(thiophen-3-yl)propan-2-yl)urea
- CAS No.
- 1997387-43-5
- Chemical Name:
- 1-((S)-2-(dimethylamino)-3-(4-hydroxyphenyl)propyl)-3-((S)-1-(thiophen-3-yl)propan-2-yl)urea
- Synonyms
- PZM-21;PZM 21; PZM-21;Opioid Receptor,Inhibitor,PZM21,inhibit,PZM 21,PZM-21;1-((S)-2-(dimethylamino)-3-(4-hydroxyphenyl)propyl)-3-((S)-1-(thiophen-3-yl)propan-2-yl)urea;1-[(2S)-2-(Dimethylamino)-3-(4-hydroxyphenyl)propyl]-3-[(2S)-1-(thiophen-3-yl)propan-2-yl]urea;Urea, N-[(2S)-2-(dimethylamino)-3-(4-hydroxyphenyl)propyl]-N'-[(1S)-1-methyl-2-(3-thienyl)ethyl]-
- CBNumber:
- CB83137417
- Molecular Formula:
- C19H27N3O2S
- Molecular Weight:
- 361.5
- MDL Number:
- MFCD30802176
- MOL File:
- 1997387-43-5.mol
Last updated:2024-07-02 08:55:24
1-((S)-2-(dimethylamino)-3-(4-hydroxyphenyl)propyl)-3-((S)-1-(thiophen-3-yl)propan-2-yl)urea Properties
Boiling point | 583.8±50.0 °C(Predicted) |
---|---|
Density | 1.169±0.06 g/cm3(Predicted) |
storage temp. | Store at -20°C |
solubility |
DMSO:100.0(Max Conc. mg/mL);276.63(Max Conc. mM) Ethanol:10.0(Max Conc. mg/mL);27.7(Max Conc. mM) |
form | A crystalline solid |
pka | 10.06±0.15(Predicted) |
color | White to off-white |
FDA UNII | M8GB23F27E |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
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Signal word | Warning | |||||||||
Hazard statements | H302-H315-H319-H335 | |||||||||
Precautionary statements | P261-P305+P351+P338 | |||||||||
NFPA 704 |
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1-((S)-2-(dimethylamino)-3-(4-hydroxyphenyl)propyl)-3-((S)-1-(thiophen-3-yl)propan-2-yl)urea price More Price(18)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Cayman Chemical | 20576 | PZM21 | 1997387-43-5 | 1mg | $33 | 2024-03-01 | Buy |
Cayman Chemical | 20576 | PZM21 | 1997387-43-5 | 25mg | $245 | 2024-03-01 | Buy |
Cayman Chemical | 20576 | PZM21 | 1997387-43-5 | 5mg | $116 | 2024-03-01 | Buy |
Cayman Chemical | 20576 | PZM21 | 1997387-43-5 | 10mg | $164 | 2024-03-01 | Buy |
Tocris | 7218 | PZM21 ≥98%(HPLC) | 1997387-43-5 | 10 | $199 | 2021-12-16 | Buy |
1-((S)-2-(dimethylamino)-3-(4-hydroxyphenyl)propyl)-3-((S)-1-(thiophen-3-yl)propan-2-yl)urea Chemical Properties,Uses,Production
Uses
PZM21 is a potent Gi activator with exceptional selectivity for μOR and minimal β-arrestin-2 recruitment. PZM21 is an experimental opioid analgesic drug that is being researched for the treatment of pain. It is a functionally selective μ-opioid receptor agonist which produces μ-opioid receptor mediated G protein signaling, with potency and efficacy similar to morphine, but with less β-arrestin 2 recruitment. In tests on mice, PZM21 was slightly less potent than morphine or TRV130 as an analgesic, but also had significantly reduced adverse effects, with less constipation than morphine, and very little respiratory depression, even at high doses.
storage
Store at -20°C
1-((S)-2-(dimethylamino)-3-(4-hydroxyphenyl)propyl)-3-((S)-1-(thiophen-3-yl)propan-2-yl)urea Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 51)Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32836 | 60 |
BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30250 | 58 |
HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
Labnetwork lnc. | +86-27-50766799 +8618062016861 | contact@labnetwork.com | China | 19994 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
Suzhou ARTK Medchem Co., Ltd. | +8618168183658 | sales1@artkmedchem.com | China | 39010 | 58 |
Watson Biotechnology Co.,Ltd | +86-18186686046 +86-18186686046 | sales01@watsonbiotech.cn | China | 5851 | 58 |
Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131980 | 58 |
Supplier | Advantage |
---|---|
ATK CHEMICAL COMPANY LIMITED | 60 |
BOC Sciences | 58 |
Career Henan Chemica Co | 58 |
HANGZHOU CLAP TECHNOLOGY CO.,LTD | 58 |
Labnetwork lnc. | 58 |
InvivoChem | 58 |
TargetMol Chemicals Inc. | 58 |
Suzhou ARTK Medchem Co., Ltd. | 58 |
Watson Biotechnology Co.,Ltd | 58 |
Amadis Chemical Company Limited | 58 |
1-((S)-2-(dimethylamino)-3-(4-hydroxyphenyl)propyl)-3-((S)-1-(thiophen-3-yl)propan-2-yl)urea
PZM-21
PZM 21; PZM-21
1-[(2S)-2-(Dimethylamino)-3-(4-hydroxyphenyl)propyl]-3-[(2S)-1-(thiophen-3-yl)propan-2-yl]urea
Urea, N-[(2S)-2-(dimethylamino)-3-(4-hydroxyphenyl)propyl]-N'-[(1S)-1-methyl-2-(3-thienyl)ethyl]-
Opioid Receptor,Inhibitor,PZM21,inhibit,PZM 21,PZM-21
1997387-43-5