ChemicalBook >> CAS DataBase List >>TPX-0005
TPX-0005
- CAS No.
- 1802220-02-5
- Chemical Name:
- TPX-0005
- Synonyms
- Repotrectinib;TPX-005;Ropotrectinib;CS-2479;TPX-0005;Loprotinib;PX0005(Ropotrectinib);Ropotrectinib(TPX0005);TPX0005(Ropotrectinib);TPX-0005,Repotrectinib
- CBNumber:
- CB83312797
- Molecular Formula:
- C18H18FN5O2
- Molecular Weight:
- 355.37
- MDL Number:
- MFCD31544350
- MOL File:
- 1802220-02-5.mol
Last updated:2023-12-20 20:39:53
| Density | 1.46±0.1 g/cm3(Predicted) |
|---|---|
| storage temp. | Store at -20°C |
| solubility |
DMSO:35.0(Max Conc. mg/mL);98.5(Max Conc. mM) Ethanol:10.0(Max Conc. mg/mL);28.1(Max Conc. mM) |
| form | A crystalline solid |
| pka | 10.79±0.60(Predicted) |
| InChI | InChI=1S/C18H18FN5O2/c1-10-8-20-18(25)14-9-21-24-6-5-16(23-17(14)24)22-11(2)13-7-12(19)3-4-15(13)26-10/h3-7,9-11H,8H2,1-2H3,(H,20,25)(H,22,23)/t10-,11+/m0/s1 |
| InChIKey | FIKPXCOQUIZNHB-WDEREUQCSA-N |
| SMILES | O1C2=CC=C(F)C=C2[C@@H](C)NC2C=CN3C(N=2)=C(C=N3)C(=O)NC[C@@H]1C |
| FDA UNII | 08O3FQ4UNP |
| NCI Drug Dictionary | repotrectinib |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| NFPA 704 |
|
TPX-0005 price More Price(15)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 23397 | TPX-0005 ≥98% | 1802220-02-5 | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 23397 | TPX-0005 ≥98% | 1802220-02-5 | 5mg | $139 | 2024-03-01 | Buy |
| Cayman Chemical | 23397 | TPX-0005 ≥98% | 1802220-02-5 | 10mg | $243 | 2024-03-01 | Buy |
| Cayman Chemical | 23397 | TPX-0005 ≥98% | 1802220-02-5 | 25mg | $533 | 2024-03-01 | Buy |
| ChemScene | CS-7628 | Repotrectinib 99.81% | 1802220-02-5 | 50mg | $590 | 2021-12-16 | Buy |
TPX-0005 Chemical Properties,Uses,Production
Description
Ropotrectinib (TPX-0005; TP Therapeutics, San Diego, CA, USA) is a nextgeneration ROS1 inhibitor, a novel three-dimensional macrocyle with a much smaller size (MW <370) than current ROS1 inhibitors. It was specifically designed to overcome resistance mutations. Preclinical studies have shown activity against gatekeeper and solvent mutations, including G2032R, D2033N, L2026M, S1986F/Y, L1951R, and kinases involved in bypass signaling such as focal adhesion kinase, SRC proto-oncogene, and non-receptor tyrosine kinase [102, 103].
Description
Repotrectinib, also known as TPX-0005, is a multikinase (ROS1, ALK, and TRKA/B/C) inhibitor that is tested in an ongoing first-in-human phase 1/2 trail (NCT03093116).
Clinical Use
Repotrectinib has advantage with central nervous system (CNS) penetration, aimed to target both wide-type (WT) and solvent-front mutations (SFM) kinases and other resistance mutations including ROS1-G2032R and ROS1-D2033N, TRKA-G595R, TRKB-G639R, TRKC-G623R, and ALK-G1202R.
TPX-0005 Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 152)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Zhengzhou Anhuida Chemical Co., Ltd | +8615903659408 | admin@ahdchem.com | China | 298 | 58 |
| Jinan Million Pharmaceutical Co., Ltd | +86-531-68659554 +8613031714605 | info@millionpharm.com | China | 154 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8617531190177 | peter@yan-xi.com | China | 5993 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21691 | 55 |
| Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 967 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
| Zhengzhou Alfa Chemical Co.,Ltd | +8618530059196 | sale04@alfachem.cn | China | 12468 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Qiuxian Baitai New Material Co., LTD | +8618330912755 | sale2@hbyalin.com | China | 1677 | 58 |
View Lastest Price from TPX-0005 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-26 | Repotrectinib/TPX-0005
1802220-02-5
|
US $2.00 / kg | 1kg | 99% | 50KG/M | Jinan Million Pharmaceutical Co., Ltd | |
 |
2023-12-20 | Repotrectinib
1802220-02-5
|
US $0.00-0.00 / kg | 1kg | 99%, Single impurity＜0.1 | 1 ton | Nanjing Fred Technology Co., Ltd | |
 |
2023-11-16 | TPX-0005
1802220-02-5
|
US $50.00 / kg | 1kg | 0.99 | 10000 | Hebei Yanxi Chemical Co., Ltd. |
-
- Repotrectinib/TPX-0005
1802220-02-5
- US $2.00 / kg
- 99%
- Jinan Million Pharmaceutical Co., Ltd
-
- Repotrectinib
1802220-02-5
- US $0.00-0.00 / kg
- 99%, Single impurity＜0.1
- Nanjing Fred Technology Co., Ltd
-
- TPX-0005
1802220-02-5
- US $50.00 / kg
- 0.99
- Hebei Yanxi Chemical Co., Ltd.
TPX-0005
TPX-0005;TPX 0005;TPX0005
CS-2479
Repotrectinib(TPX-005)
Repotrectinib,TPX-0005
1,15-Etheno-1H-pyrazolo[4,3-f][1,4,8,10]benzoxatriazacyclotridecin-4(5H)-one,11-fluoro-6,7,13,14-tetrahydro-7,13-dimethyl-, (7S,13R)-
TPX-0005,Repotrectinib
TPX0005(Ropotrectinib)
Ropotrectinib(TPX0005)
Loprotinib
Ropotrectinib
Repotrectinib
TPX-005
(7S,13R)-11-Fluoro-6,7,13,14-tetrahydro-7,13-dimethyl-1,15-etheno-1H-pyrazolo[4,3-f][1,4,8,10]benzoxatriazacyclotridecin-4(5H)-one
PX0005(Ropotrectinib)
1802220-02-5
180222-02-5
API
1802220-02-5