M-3M3FBS
- CAS No.
- 200933-14-8
- Chemical Name:
- M-3M3FBS
- Synonyms
- M-3M3FBS;Phospholipase C Activator,;2,4,6-TRIMETHYL-N-(3-(TRIFLUOROMETHYL)PH;N-(3-TRIFLUOROMETHYLPHENYL)-2,4,6-TRIMETHYLBENZENESULFONAMIDE;2,4,6-TRIMETHYL-N-(M-3-TRIFLUOROMETHYLPHENYL)BENZENESULFONAMIDE;2,4,6-TRIMETHYL-N-[3-(TRIFLUOROMETHYL)PHENYL]BENZENESULFONAMIDE;Benzenesulfonamide, 2,4,6-trimethyl-N-[3-(trifluoromethyl)phenyl]-;Phospholipase C Activator, m-3M3FBS - CAS 200933-14-8 - Calbiochem;calcium,superoxide,cells,THP-1,phosphate,m 3M3FBS,m-3M3FBS,Apoptosis,Inhibitor,m3M3FBS,Phospholipase,leukemic,U937,inositol,inhibit,neutrophils,m-3M-3FBS
- CBNumber:
- CB8335416
- Molecular Formula:
- C16H16F3NO2S
- Molecular Weight:
- 343.36
- MDL Number:
- MFCD00095824
- MOL File:
- 200933-14-8.mol
- MSDS File:
- SDS
| Melting point | 114-114.8 °C(lit.) |
|---|---|
| Boiling point | 420.0±55.0 °C(Predicted) |
| Density | 1.316±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMSO: 92 mg/mL |
| form | solid |
| pka | 7.82±0.10(Predicted) |
| color | white |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month. |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Safety Statements | 22-24/25 | |||||||||
| WGK Germany | 3 | |||||||||
| NFPA 704 |
|
M-3M3FBS price More Price(26)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | T5699 | m-3M3FBS >97% (HPLC) | 200933-14-8 | 10mg | $148 | 2024-03-01 | Buy |
| Sigma-Aldrich | 525185 | Phospholipase C Activator, The Phospholipase C Activator, | 200933-14-8 | 10mg | $111 | 2024-03-01 | Buy |
| Alfa Aesar | J65999 | 2,4,6-Trimethyl-N-[3-(trifluoromethyl)phenyl]benzenesulfonamide | 200933-14-8 | 10mg | $101 | 2021-12-16 | Buy |
| Alfa Aesar | J65999 | 2,4,6-Trimethyl-N-[3-(trifluoromethyl)phenyl]benzenesulfonamide | 200933-14-8 | 50mg | $321 | 2021-12-16 | Buy |
| Cayman Chemical | 16867 | m-3M3FBS ≥95% | 200933-14-8 | 5mg | $49 | 2024-03-01 | Buy |
M-3M3FBS Chemical Properties,Uses,Production
Description
m-3M3FBS (200933-14-8) is an activator of phospholipase C (PLC). Stimulates superoxide generation, Ca2+ release and inositol phosphate release in a variety of cell types.1?Inhibits growth of U937 and THP-1 cells.2 m-3M3FBS also affects calcium homeostasis independently of PLC activation.3
Uses
m-3M3FBS is used in biological studies as phospholipase C activator m-3M3FBS effects on Ca2+ homeostasis independently of phospholipase C activation.
Uses
m-3M3FBS has been used for MAP kinase assay in 293T cells. It has also been used for intracellular calcium analysis1. Furthermore, it has been used (at a conc. of 1 μM) as a PLC activator for sensitizing TRPA1 in HEK293t cells2.
Definition
ChEBI: 2,4,6-trimethyl-N-[3-(trifluoromethyl)phenyl]benzenesulfonamide is a sulfonamide.
Biological Activity
Activator of phospholipase C (PLC). Stimulates superoxide generation, Ca 2+ release and inositol phosphate formation in a variety of cell types.
Biochem/physiol Actions
First known direct activator of phospholipase C (activates β2, β3, γ1, γ2, δ1 isoforms).
storage
Store at RT
References
1) Bae?et al. (2003),?Identification of a compound that directly stimulates phospholipase C activity; Mol. Pharmacol.,?63?1043 2) Lee?et al. (2005),?The novel phospholipase C activator, m-3M3FBS, induces monocytic leukemia cell apoptosis; Cancer Lett.,?222?227 3) Krjukova?et al. (2004),?Phospholipase C activator m-3M3FBS affects Ca2+ homeostasis independently of phospholipase C activation; Br. J. Pharmacol.,?143?3
M-3M3FBS Preparation Products And Raw materials
Raw materials
Preparation Products
M-3M3FBS Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32715 | 60 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30132 | 84 |
| VDM Biochemicals | 0330-2528181 | sales@vdmbio.com | United States | 510 | 64 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 14059 | 65 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4182 | 55 |
| Supplier | Advantage |
|---|---|
| ATK CHEMICAL COMPANY LIMITED | 60 |
| InvivoChem | 58 |
| TargetMol Chemicals Inc. | 58 |
| Aladdin Scientific | 58 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 69 |
| Alfa Aesar | 84 |
| VDM Biochemicals | 64 |
| BOC Sciences | 65 |
| Sigma-Aldrich | 80 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 55 |
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