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ChemicalBook >> CAS DataBase List >>1-[4-(4-aminofuro[2,3-d]pyrimidin-5-yl)phenyl]-3-[2-fluoro-5-(trifluoromethyl)phenyl]urea

1-[4-(4-aminofuro[2,3-d]pyrimidin-5-yl)phenyl]-3-[2-fluoro-5-(trifluoromethyl)phenyl]urea

1-[4-(4-aminofuro[2,3-d]pyrimidin-5-yl)phenyl]-3-[2-fluoro-5-(trifluoromethyl)phenyl]urea Structure
1-[4-(4-aminofuro[2,3-d]pyrimidin-5-yl)phenyl]-3-[2-fluoro-5-(trifluoromethyl)phenyl]urea structure
CAS No.
501693-48-7
Chemical Name:
1-[4-(4-aminofuro[2,3-d]pyrimidin-5-yl)phenyl]-3-[2-fluoro-5-(trifluoromethyl)phenyl]urea
Synonyms
Cpd27;RIP1 Kinase Inhibitor III;TIE-2/VEGFR-2 kinase-IN-2;1-[4-(4-aminofuro[2,3-d]pyrimidin-5-yl)phenyl]-3-[2-fluoro-5-(trifluoromethyl)phenyl]urea;3-(4-{4-aminofuro[2,3-d]pyrimidin-5-yl}phenyl)-1-[2-fluoro-5-(trifluoromethyl)phenyl]urea;Urea,N-[4-(4-aminofuro[2,3-α]pyrimidin-5-yl)phenyl]-N-[2-fluoro-5-(trifluoromethyl)phenyl]-;4-Amino-5-[4-[[[[2-fluoro-5-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenyl]furo[2,3-d]pyrimidine
CBNumber:
CB83858514
Molecular Formula:
C20H13F4N5O2
Molecular Weight:
431.3431328
MDL Number:
MOL File:
501693-48-7.mol
Last updated:2025-07-27 11:38:58
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1-[4-(4-aminofuro[2,3-d]pyrimidin-5-yl)phenyl]-3-[2-fluoro-5-(trifluoromethyl)phenyl]urea Properties

storage temp. 2-8°C
solubility DMSO: 50mg/mL
form Solid
color White to off-white
UNSPSC Code 12352200

1-[4-(4-aminofuro[2,3-d]pyrimidin-5-yl)phenyl]-3-[2-fluoro-5-(trifluoromethyl)phenyl]urea Chemical Properties,Uses,Production

Uses

TIE-2/VEGFR-2 kinase-IN-2 is a potent dual VEGFR2 and Tie-2 inhibitor with pIC50 values of 8.61 and 8.56, respectively[1]. TIE-2/VEGFR-2 kinase-IN-2 is an anti-angiogenic agent and can be used for cancer research[2].

Biological Activity

Cell permeable: yes', 'Primary Target
RIP1 Kinase

IC 50

Tie2: 8.56 nM (pIC50); VEGFR-2; Tie-2

References

[1] Yasushi Miyazaki, et al. Orally active 4-amino-5-diarylurea-furo[2,3-d]pyrimidine derivatives as anti-angiogenic agent inhibiting VEGFR2 and Tie-2. Bioorg Med Chem Lett. 2007 Mar 15;17(6):1773-8. DOI:10.1016/j.bmcl.2006.12.077

1-[4-(4-aminofuro[2,3-d]pyrimidin-5-yl)phenyl]-3-[2-fluoro-5-(trifluoromethyl)phenyl]urea Preparation Products And Raw materials

Raw materials

Preparation Products

1-[4-(4-aminofuro[2,3-d]pyrimidin-5-yl)phenyl]-3-[2-fluoro-5-(trifluoromethyl)phenyl]urea Suppliers

Global( 16)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32376 58
Hangzhou MolCore BioPharmatech Co.,Ltd. 		+86-057181025280; +8617767106207 sales@molcore.com China 49734 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		13417589054 trendseenbio@gmail.com China 11681 58
Aceschem Inc. 		+1-817863-6948 +1-（817）863-6948 sales@aceschem.com United States 19632 58
Shanghai Chaolan Chemical Technology Center 021-QQ：65489617 15618227136 Sales@ATKchemical.com China 9364 58
Suzhou Chenrui Biotechnology Co. LTD 17625585511 1580084073@qq.com China 879 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24982 58
Shanghai Tachizaki Biomedical Research Center 18014399201 sales@chemlab-tachizaki.com China 2678 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 13417589054 trendseenbio@gmail.com China 9070 58
Nantong QuanYi Biotechnology Co., Ltd 0513-66337626 18051384581 sales@chemhifuture.com China 5656 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
Hangzhou MolCore BioPharmatech Co.,Ltd. 		58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		58
Aceschem Inc. 		58
Shanghai Chaolan Chemical Technology Center 58
Suzhou Chenrui Biotechnology Co. LTD 58
TargetMol Chemicals Inc. 58
Shanghai Tachizaki Biomedical Research Center 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 58
Nantong QuanYi Biotechnology Co., Ltd 58

View Lastest Price from 1-[4-(4-aminofuro[2,3-d]pyrimidin-5-yl)phenyl]-3-[2-fluoro-5-(trifluoromethyl)phenyl]urea manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Cpd27 pictures 2025-07-26 Cpd27
501693-48-7
 US $58.00-228.00 / mg 98.89% 10g TargetMol Chemicals Inc.
  • Cpd27 pictures
  • Cpd27
    501693-48-7
  • US $58.00-228.00 / mg
  • 98.89%
  • TargetMol Chemicals Inc.
1-[4-(4-aminofuro[2,3-d]pyrimidin-5-yl)phenyl]-3-[2-fluoro-5-(trifluoromethyl)phenyl]urea TIE-2/VEGFR-2 kinase-IN-2 4-Amino-5-[4-[[[[2-fluoro-5-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenyl]furo[2,3-d]pyrimidine Urea,N-[4-(4-aminofuro[2,3-α]pyrimidin-5-yl)phenyl]-N-[2-fluoro-5-(trifluoromethyl)phenyl]- 3-(4-{4-aminofuro[2,3-d]pyrimidin-5-yl}phenyl)-1-[2-fluoro-5-(trifluoromethyl)phenyl]urea Cpd27 RIP1 Kinase Inhibitor III 501693-48-7