ANTI-CORTISOL
- CAS No.
- Chemical Name:
- ANTI-CORTISOL
- Synonyms
- ANTI-CORTISOL;ANTI-HYDROCORTISONE;ANTI-CORTISOL MOUSE MAB;Anti-Cortisol antibody produced in rabbit
- CBNumber:
- CB8431624
- Molecular Formula:
- C21H30O5
- Molecular Weight:
- 362.4599
- MDL Number:
- MFCD00162244
- MOL File:
- Mol file
ANTI-CORTISOL Chemical Properties,Uses,Production
Uses
Anti-Cortisol antibody has been used in Plasma hormone assay and immunofluorescence.
General Description
Cortisol is the principal secretary glucocorticoid of human adrenal cortex. It is produced as cortisone but converted to a biologically active form, cortisol, by the activity of enzyme 11β- hydroxysteroid dehydrogenase (11-HSD).
Biochem/physiol Actions
Cortisol is the principal secretary glucocorticoid of human adrenal cortex. It is produced as cortisone but converted to a biologically active form, cortisol, by the activity of enzyme 11β- hydroxysteroid dehydrogenase (11-HSD). Cortisol is bound to corticosteroid-binding globulin in the plasma. The organs that produce 11-HSD and involved in metabolizing and clearing it from plasma cortisol are kidney and the liver. Cortisol may be oxidised at 11-hydroxt position to result in the production of cortisone, dihydrocortisone, or tetrahydrocortisone. Cortisol and other glucocorticoids bind to the human glucocorticoid receptor (hGR) that is predominantly present in the cytoplasm. On binding, the recptor-ligand complex translocate to nucleus where the transcription of target genes is induced. Deficiency in the levels of 11-HSD are responsible for juvenile hypertension, (a feature of Apparent Mineralocorticoid Excess syndrome), edema, heart failure and hypokalemia (licorice intoxication).
ANTI-CORTISOL Preparation Products And Raw materials
Raw materials
Preparation Products
ANTI-CORTISOL Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
Supplier | Advantage |
---|---|
Sigma-Aldrich | 80 |