ChemicalBook
Chinese Japanese Germany Korea

Hydrocortisone

Hydrocortisone
Hydrocortisone structure
CAS No.
50-23-7
Chemical Name:
Hydrocortisone
Synonyms
HC;hvb;Optef;H-Cort;Hycort;Hytone;Signef;wycort;Alacort;Cleiton
CBNumber:
CB9756715
Molecular Formula:
C21H30O5
Formula Weight:
362.46
MOL File:
50-23-7.mol

Hydrocortisone Properties

Melting point:
211-214 °C(lit.)
alpha 
166 º (c=1, C2H5OH 25 ºC)
Boiling point:
414.06°C (rough estimate)
Density 
1.0812 (rough estimate)
refractive index 
1.6120 (estimate)
Flash point:
220°C
storage temp. 
−20°C
solubility 
H2O: 100 mg/mL
form 
powder
color 
White
Water Solubility 
319.7mg/L(25 ºC)
Decomposition 
220 ºC
Merck 
14,4787
BRN 
1354819
Stability:
Stable, but may be light sensitive. Incompatible with strong oxidizing agents.
CAS DataBase Reference
50-23-7(CAS DataBase Reference)
EWG's Food Scores
1
FDA UNII
WI4X0X7BPJ
NCI Dictionary of Cancer Terms
cortisol; hydrocortisone
NIST Chemistry Reference
Hydrocortisone(50-23-7)
EPA Substance Registry System
Hydrocortisone (50-23-7)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS02,GHS06,GHS08
Signal word  Danger
Hazard statements  H361-H225-H301+H311+H331-H370
Precautionary statements  P280-P210-P302+P352+P312-P304+P340+P312-P370+P378-P403+P235-P201-P202-P308+P313-P405-P501a
Hazard Codes  Xn,T,F
Risk Statements  63-62-40-39/23/24/25-23/24/25-11
Safety Statements  36/37-45-36-22-16-7
RIDADR  UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany  3
RTECS  GM8925000
TSCA  Yes
HS Code  29372100
Toxicity LD50 subcutaneous in mouse: > 500mg/kg

Hydrocortisone price More Price(27)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 386698 Hydrocortisone, Chromatographic Standard 50-23-7 25mg $86 2019-12-02 Buy
Sigma-Aldrich 1316004 Hydrocortisone United States Pharmacopeia (USP) Reference Standard 50-23-7 200mg $352.8 2019-12-02 Buy
Alfa Aesar A16292 Hydrocortisone, 98% 50-23-7 1g $24.8 2020-06-24 Buy
Alfa Aesar A16292 Hydrocortisone, 98% 50-23-7 5g $81.7 2020-06-24 Buy
Cayman Chemical 20739 Hydrocortisone ≥98% 50-23-7 1g $21 2020-06-24 Buy

Hydrocortisone Chemical Properties,Uses,Production

Chemical Properties

crystalline white powder

Uses

Principle glucocorticoid hormone produced by adrenal cortex. An anti-inflammatory hormone.

Uses

glucocorticoid, antiinflammatory

Uses

Cortisol, or Hydrocortisone, is a steroid hormone, more specifically a glucocorticoid, produced by the zona fasciculata of the adrenal gland. Cortisol is released in response to stress and a low level of blood glucocorticoids. Its primary functions are to increase blood sugar through gluconeogenesis; suppress the immune system; and aid in fat, protein and carbohydrate metabolism.

Definition

ChEBI: A C21-steroid that is pregn-4-ene substituted by oxo groups at positions 3 and 20 and hydroxy groups at positions 11, 17 and 21. Cortisol is a corticosteroid hormone or glucocorticoid produced by zona fasciculata of the adrenal cortex, which is a part of the adrenal gland. It is usually referred to as the "stress hormone" as it is involved in response to stress and anxiety, controlled by corticotropin-releasing hormone (CRH). It increases blood pressure and blood sugar, and reduces immun responses

Indications

Hydrocortisone (Cortizone, Cortaid, Anusol-HC, Hytone, LactiCare-HC, Sarnol HC, Penecort, Texacort, and many other branded products) may be purchased as a generic drug.

brand name

Acticort (Baker Norton); Ala-Cort (Del Ray); Cetacort (Healthpoint); Colocort (Paddock); Cort- Dome (Bayer); Cortef (Pharmacia & Upjohn); Cortenema (Solvay Pharmaceuticals); Cortril (Pfizer); Dermacort (Monarch); Dermacort (Solvay Pharmaceuticals); Eldecort (Valeant); Epicort (Bluline); Flexicort (Westwood- Squibb); Glycort (Heran); Hi-Cor (C & M); Hydro-Rx (X Gen); Hydrocortone (Merck); Hytone (Dermik); Hytone (Sanofi Aventis); Nutracort (Healthpoint); Penecort (Allergan); Proctocort (Monarch); Stie-Cort (Stiefel); Synacort (Medicis); Texacort (Sirius).

General Description

Hydrocortisone, 11β,17,21-trihydroxypregn-4-ene-3,20-dione, is the primary natural GCin humans. Despite the large number of synthetic GCs, hydrocortisone,its esters, and its salts remain a mainstay ofmodern adrenocortical steroid therapy and the standard forcomparison of all other GCs and MCs . It isused for all the indications mentioned previously.

Health Hazard

Cortisol Increases (1) protein catabolism (excepting liver) gluconeogenesis; (2) carbohydrate anabolism (liver); (3) blood sugar; (4) glucose absorption; (5) brain excitation; (6) spread of infections; (7)urinary glucose and nitrogen; (8) stress tolerance; (9) lactation; (10) water diuresis.
Regulates general adaptation syndrome, water balance, blood pressure, and hormone release.
Decreases (1) fat anabolism; (2) growth rate; (3) inflammation; (4) eosinophils; (5) lymphocytes; (6) antigen sensitivity; (7) respiratory quotient; (8) ketosis; (9) wound healing; (10) skin pigmentation; (11)RBC hemolysis.

Contact allergens

Hydrocortisone is the principal glucocorticoid hor- mone produced by the adrenal cortex and is used topi- cally or systemically. It belongs to the allergenic A group. Marker of allergy is tixocortol pivalate.

Safety Profile

Poison by

Veterinary Drugs and Treatments

Because of its rapid effect and relatively high mineralocorticoid effect, hydrocortisone sodium succinate (Solu-Cortef?) is the most commonly used form of this medication when an acute glucocorticoid/ mineralocorticoid effect is desired (e.g., acute adrenal insufficiency). Corticosteroids have not been shown beneficial in treating hypovolemic shock, but low dose glucocorticoids probably reduce mortality associated with septic shock.
Glucocorticoids have been used in an attempt to treat practically every malady that afflicts man or animal, but there are three broad uses and dosage ranges for use of these agents. 1) Replacement of glucocorticoid activity in patients with adrenal insufficiency, 2) as an antiinflammatory agent, and 3) as an immunosuppressive. Among some of the uses for glucocorticoids include treatment of: endocrine conditions (e.g., adrenal insufficiency), rheumatic diseases (e.g., rheumatoid arthritis), collagen diseases (e.g., systemic lupus), allergic states, respiratory diseases (e.g., asthma), dermatologic diseases (e.g., pemphigus, allergic dermatoses), hematologic disorders (e.g., thrombocytopenias, autoimmune hemolytic anemias), neoplasias, nervous system disorders (increased CSF pressure), GI diseases (e.g., ulcerative colitis exacerbations), and renal diseases (e.g., nephrotic syndrome). Some glucocorticoids are used topically in the eye and skin for various conditions or are injected intra-articularly or intra-lesionally. The above listing is certainly not complete.

Purification Methods

Recrystallise hydrocortisone from EtOH or isoPrOH. It is bitter tasting and has UV with max at 242 nm (log 4.20). Its solubility at 25o is: H2O (0.28%), EtOH (1.5%), MeOH (0.62%), Me2CO (0.93%), CHCl3 (0.16%), propylene glycol (1.3%) and Et2O (0.35%). It gives an intense green colour with conc H2SO4. [Wendler et al. J Am Chem Soc 72 5793 1950, Beilstein 8 IV 3422.]

Hydrocortisone Preparation Products And Raw materials

Raw materials

Preparation Products


Hydrocortisone Suppliers

Global( 443)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
PI & PI BIOTECH INC.
18371201331
020-81716319 Sales@pipitech.com CHINA 3050 55
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21821 58
Beijing Cooperate Pharmaceutical Co.,Ltd.
+86-10-60279497 +86(0)15646567669
+86-10-60279497 sales01@cooperate-pharm.com CHINA 1817 55
Shanghai Bojing Chemical Co.,Ltd.
+86-21-37122233
+86-21-37127788 Candy@bj-chem.com CHINA 497 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22626 55
Hubei XinRunde Chemical Co., Ltd.
+8615102730682
02783214688 bruce@xrdchem.cn CHINA 568 55
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 info@tnjchem.com China 2404 55
Hebei Chisure Biotechnology Co., Ltd.
+8613292890173
0311 66567340 luna@speedgainpharma.com CHINA 1009 58
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3623 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30045 58

View Lastest Price from Hydrocortisone manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2020-05-28 Hydrocortisone
50-23-7
US $0.00 / mg 100mg ≥98%(HPLC) 100 g Shanghai Standard Technology Co., Ltd.
2019-07-04 Hydrocortisone
50-23-7
US $10.00 / KG 1KG 99% 10 mt Hebei Guanlang Biotechnology Co., Ltd.
2019-11-08 cortisol
50-23-7
US $50.00 / KG 10g 99.8% 10tons Hebei shuoxi biotechnology co. LTD

Hydrocortisone Spectrum


50-23-7(Hydrocortisone)Related Search:


Copyright 2017 © ChemicalBook. All rights reserved