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Hydrocortisone

Hydrocortisone
Hydrocortisone structure
CAS No.
50-23-7
Chemical Name:
Hydrocortisone
Synonyms
HC;hvb;Optef;H-Cort;Hycort;Hytone;Signef;wycort;Alacort;Cleiton
CBNumber:
CB9756715
Molecular Formula:
C21H30O5
Formula Weight:
362.46
MOL File:
50-23-7.mol

Hydrocortisone Properties

Melting point:
211-214 °C(lit.)
alpha 
166 º (c=1, C2H5OH 25 ºC)
Boiling point:
414.06°C (rough estimate)
Density 
1.0812 (rough estimate)
refractive index 
1.6120 (estimate)
Flash point:
220°C
storage temp. 
−20°C
solubility 
H2O: 100 mg/mL
form 
powder
color 
White
Decomposition 
220 ºC
Merck 
14,4787
BRN 
1354819
Stability:
Stable, but may be light sensitive. Incompatible with strong oxidizing agents.
CAS DataBase Reference
50-23-7(CAS DataBase Reference)
NIST Chemistry Reference
Hydrocortisone(50-23-7)
EPA Substance Registry System
Pregn-4-ene-3,20- dione, 11,17,21-trihydroxy-, (11.beta.)-(50-23-7)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xn,T,F
Risk Statements  63-62-40-39/23/24/25-23/24/25-11
Safety Statements  36/37-45-36-22-16-7
RIDADR  UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany  3
RTECS  GM8925000
TSCA  Yes
Hazardous Substances Data 50-23-7(Hazardous Substances Data)
Symbol(GHS):
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H225 Highly Flammable liquid and vapour Flammable liquids Category 2 Danger P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H361 Suspected of damaging fertility or the unborn child Reproductive toxicity Category 2 Warning P201, P202, P281, P308+P313, P405,P501
H370 Causes damage to organs Specific target organ toxicity, single exposure Category 1 Danger P260, P264, P270, P307+P311, P321,P405, P501
Precautionary statements:
P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P308+P313 IF exposed or concerned: Get medical advice/attention.
P370+P378 In case of fire: Use … for extinction.
P405 Store locked up.
P403+P235 Store in a well-ventilated place. Keep cool.

Hydrocortisone price More Price(26)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 386698 Hydrocortisone, Chromatographic Standard 50-23-7 25mg $86 2018-11-20 Buy
Sigma-Aldrich 1316004 Hydrocortisone United States Pharmacopeia (USP) Reference Standard 50-23-7 200mg $352.8 2018-11-20 Buy
Alfa Aesar A16292 Hydrocortisone, 98% 50-23-7 1g $23.1 2018-11-13 Buy
Alfa Aesar A16292 Hydrocortisone, 98% 50-23-7 5g $77.5 2018-11-13 Buy
Cayman Chemical 20739 Hydrocortisone ≥98% 50-23-7 1g $21 2018-11-19 Buy

Hydrocortisone Chemical Properties,Uses,Production

Chemical Properties

crystalline white powder

Uses

Principle glucocorticoid hormone produced by adrenal cortex. An anti-inflammatory hormone.

Uses

glucocorticoid, antiinflammatory

Uses

Cortisol, or Hydrocortisone, is a steroid hormone, more specifically a glucocorticoid, produced by the zona fasciculata of the adrenal gland. Cortisol is released in response to stress and a low level of blood glucocorticoids. Its primary functions are to increase blood sugar through gluconeogenesis; suppress the immune system; and aid in fat, protein and carbohydrate metabolism.

Definition

ChEBI: A C21-steroid that is pregn-4-ene substituted by oxo groups at positions 3 and 20 and hydroxy groups at positions 11, 17 and 21. Cortisol is a corticosteroid hormone or glucocorticoid produced by zona fasciculata of the adrenal cortex, which is a part of the adrenal gland. It is usually referred to as the "stress hormone" as it is involved in response to stress and anxiety, controlled by corticotropin-releasing hormone (CRH). It increases blood pressure and blood sugar, and reduces immun responses

brand name

Acticort (Baker Norton); Ala-Cort (Del Ray); Cetacort (Healthpoint); Colocort (Paddock); Cort- Dome (Bayer); Cortef (Pharmacia & Upjohn); Cortenema (Solvay Pharmaceuticals); Cortril (Pfizer); Dermacort (Monarch); Dermacort (Solvay Pharmaceuticals); Eldecort (Valeant); Epicort (Bluline); Flexicort (Westwood- Squibb); Glycort (Heran); Hi-Cor (C & M); Hydro-Rx (X Gen); Hydrocortone (Merck); Hytone (Dermik); Hytone (Sanofi Aventis); Nutracort (Healthpoint); Penecort (Allergan); Proctocort (Monarch); Stie-Cort (Stiefel); Synacort (Medicis); Texacort (Sirius).

General Description

Hydrocortisone, 11β,17,21-trihydroxypregn-4-ene-3,20-dione, is the primary natural GCin humans. Despite the large number of synthetic GCs, hydrocortisone,its esters, and its salts remain a mainstay ofmodern adrenocortical steroid therapy and the standard forcomparison of all other GCs and MCs . It isused for all the indications mentioned previously.

Contact allergens

Hydrocortisone is the principal glucocorticoid hor- mone produced by the adrenal cortex and is used topi- cally or systemically. It belongs to the allergenic A group. Marker of allergy is tixocortol pivalate.

Safety Profile

Poison by

Purification Methods

Recrystallise hydrocortisone from EtOH or isoPrOH. It is bitter tasting and has UV with max at 242 nm (log 4.20). Its solubility at 25o is: H2O (0.28%), EtOH (1.5%), MeOH (0.62%), Me2CO (0.93%), CHCl3 (0.16%), propylene glycol (1.3%) and Et2O (0.35%). It gives an intense green colour with conc H2SO4. [Wendler et al. J Am Chem Soc 72 5793 1950, Beilstein 8 IV 3422.]

Hydrocortisone Preparation Products And Raw materials

Raw materials

Preparation Products


Hydrocortisone Suppliers

Global( 389)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Hebei Guanlang Biotechnology Co., Ltd.
+86-0311-66562153 whatsapp +8615203118427
+86-0311-66562153 sales@crovellbio.com CHINA 416 50
Shenzhen Sendi Biotechnology Co.Ltd.
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0755-23311925 Abel@chembj.com CHINA 3217 55
Henan DaKen Chemical CO.,LTD.
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Beijing Cooperate Pharmaceutical Co.,Ltd.
+86-10-60279497 +86(0)15646567669
+86-10-60279497 sales01@cooperate-pharm.com CHINA 1530 55
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+86-0592-6210733 sales@mainchem.com CHINA 32651 55
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86-0551-65418684 18949823763
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View Lastest Price from Hydrocortisone manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-12-17 Hydrocortisone
50-23-7
US $7.00 / kg 1kg 99% 100KG career henan chemical co
2018-03-09 Hydrocortisone
50-23-7
US $100.00 / KG 10G 99.9% 100kg/week Hubei XinRunde Chemical Co., Ltd.
2018-05-03 Hydrocortisone
50-23-7
US $1.00 / KG 10KG 99% 1000kg Meihua Biological Technology Co.,Ltd

Hydrocortisone Spectrum


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