MRS 1523
- CAS No.
- 212329-37-8
- Chemical Name:
- MRS 1523
- Synonyms
- MRS 1523 >98% (HPLC);UUSHFEVEROROSP-UHFFFAOYSA-N;3-propyl-6-ethyl-5-[(ethylthio)carbonyl]-2 phenyl-4-propyl-3-pyridine carboxylate;3-Pyridinecarboxylic acid, 6-ethyl-5-[(ethylthio)carbonyl]-2-phenyl-4-propyl-, propyl ester
- CBNumber:
- CB8497073
- Molecular Formula:
- C23H29NO3S
- Molecular Weight:
- 399.55
- MDL Number:
- MFCD03787977
- MOL File:
- 212329-37-8.mol
- MSDS File:
- SDS
Boiling point | 551.3±50.0 °C(Predicted) |
---|---|
Density | 1.100±0.06 g/cm3(Predicted) |
storage temp. | 2-8°C |
solubility | DMSO: >10 mg/mL |
pka | 1.44±0.28(Predicted) |
form | oil |
color | colorless to light brown |
FDA UNII | 6D9Q2QUU75 |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS02,GHS07 |
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Signal word | Danger | |||||||||
Hazard statements | H225-H319 | |||||||||
Precautionary statements | P210-P233-P240-P241-P242-P243-P264-P280-P303+P361+P353-P305+P351+P338-P337+P313-P370+P378-P403+P235-P501 | |||||||||
WGK Germany | 3 | |||||||||
NFPA 704 |
|
MRS 1523 price More Price(16)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | M1809 | MRS 1523 >98% (HPLC) | 212329-37-8 | 5mg | $309 | 2024-03-01 | Buy |
Sigma-Aldrich | M1809 | MRS 1523 >98% (HPLC) | 212329-37-8 | 25mg | $1230 | 2024-03-01 | Buy |
Cayman Chemical | 17128 | MRS 1523 ≥98% | 212329-37-8 | 1mg | $56 | 2024-03-01 | Buy |
Cayman Chemical | 17128 | MRS 1523 ≥98% | 212329-37-8 | 5mg | $188 | 2024-03-01 | Buy |
Cayman Chemical | 17128 | MRS 1523 ≥98% | 212329-37-8 | 10mg | $348 | 2024-03-01 | Buy |
MRS 1523 Chemical Properties,Uses,Production
Description
MRS1523 is a selective adenosine A3 receptor antagonist (Kis = 18.9 and 113 nM for human and rat A3 receptors, respectively, versus Kis = 15.6 and 2.05 μM for rat A1 and A2A receptors, respectively). As activation of the A3 receptor is linked to several second messenger systems for signaling pathways involving inflammatory, asthmatic, and ischemic responses, this selective antagonist may be useful in characterizing the various functions of the receptor.
Uses
MRS 1523 is a selective A3 adenosine receptor (A3AR) antagonist in human and rat.
Biochem/physiol Actions
MRS 1523 is a selective?adenosine A3 receptor antagonist in the rat.
in vitro
mrs1523 reversed the increase in mrna expression in b16-f10 melanoma cells. also, mrs1523 antagonized the modulation in the expression level of the proteins, which indicated that adenosine a3r mediated the responses [1].
in vivo
c57bl/6j, male mice, inoculated b16-f10 melanoma cells, were administered mrs1523 at a dose of 100 μg/kg orally twice daily for 15 days. mrs1523 counteracted the activity of ib-meca which is an adenosine a3r agonist. in addition, it was demonstrated that the response was adenosine a3r mediated. the modulation of up-regulation of gsk-3β expression level was neutralized by mrs1523, further suggesting the specificity of the response [1].
References
[1]. madi, l., rosenberg-haggen, b., nyska, a., & korenstein, r. enhancing pigmentation via activation of a3 adenosine receptors in b16 melanoma cells and in human skin explants. experimental dermatology. 2012; 22(1): 74-77.
MRS 1523 Preparation Products And Raw materials
Raw materials
Preparation Products
MRS 1523 Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
Chembest Research Laboratories Limited | +86-21-20908456 | sales@BioChemBest.com | China | 6008 | 61 |
BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 14059 | 65 |
Beijing Yisiyan Technology Research Center | 010-56645598 13366904824 | bjkaida@163.com | China | 1613 | 59 |
Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9707 | 58 |
ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
Energy Chemical | 021-58432009 400-005-6266 | marketing@energy-chemical.com | China | 44941 | 58 |
Changzhou Furuisi Biotechnology Co., Ltd | 0519-85524369 | 3477467573@qq.com | China | 8618 | 58 |
Beijing Fuchen Technology Co., Ltd | 15652759959 | 623245911@qq.com | China | 462 | 58 |