ANTI-TYK2
- CAS No.
- Chemical Name:
- ANTI-TYK2
- Synonyms
- Anti-JTK1;ANTI-TYK2;ANTI-HUMAN TYK2;Anti-tyrosine kinase 2;RABBIT ANTI-HUMAN TYK2;Anti-TYK2 antibody produced in rabbit;Anti-Non-receptor tyrosine-protein kinase TYK2;Monoclonal Anti-TYK2 antibody produced in mouse;Anti-TYK2 (106-120) antibody produced in rabbit;Anti-TYK2 (1046-1060) antibody produced in rabbit
- CBNumber:
- CB8739733
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MFCD01634345
- MOL File:
- Mol file
SAFETY
Risk and Safety Statements
| PPE | Eyeshields, Gloves, multi-purpose combination respirator cartridge (US) |
|---|---|
| Storage Class | 10 - Combustible liquids |
ANTI-TYK2 price More Price(7)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | WH0007297M1 | Monoclonal Anti-TYK2 antibody produced in mouse clone 6G12, purified immunoglobulin, buffered aqueous solution | 100μG | $580 | 2026-04-30 | Buy | |
| Sigma-Aldrich | SAB4503050 | Anti-TYK2 antibody produced in rabbit affinity isolated antibody | 100μg | $560 | 2026-04-30 | Buy | |
| Sigma-Aldrich | SAB1404502 | Monoclonal Anti-TYK2 antibody produced in mouse clone 6H1, purified immunoglobulin, buffered aqueous solution | 100μg | $580 | 2026-04-30 | Buy | |
| Sigma-Aldrich | HPA005157 | Anti-TYK2 antibody produced in rabbit Prestige Antibodies? Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution | 100μL | $607 | 2026-04-30 | Buy | |
| Sigma-Aldrich | HPA005157 | Anti-TYK2 antibody produced in rabbit Prestige Antibodies? Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution | 25μL | $282 | 2023-06-20 | Buy |
ANTI-TYK2 Chemical Properties, Uses, Production
Uses
This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E. (provided by RefSeq)
Biological Activity
TYK2 (Tyrosine kinase 2) plays an important role in cell signaling by multiple cytokines via the JAK-ST at pathway. Tyk2 interacts with type I IFN, p40-sharing IL-12 and IL-23, IL-6, and IL-10 family receptors and helps in immunomodulation. On binding, TYK2 is phosphorylated and co-activated with JAK1 and/or JAK2. It has been suggested th at TYK2 is required for the surface expression of human IL-10R as well as human type I IFNR. TYK2 is also involved in the differentiation of immune cells, such as B cells, T helper cells and natural killer cells. Abnormal TYK2 expression is implicated in the etiology of several auto-immune diseases such as multiple sclerosis, rheumatoid arthritis and systemic lupus erythematosus. Studies show th at TYK2 rs34536443 polymorphism is associated with endometriosis and related infertility.
ANTI-TYK2 Preparation Products And Raw materials
Raw materials
Preparation Products
ANTI-TYK2 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Atlas antibodies | -- | order@atlasantibodies.com | China | 6586 | 58 |
| Merck KGaA | -- | ordercn@merckgroup.com | China | 6376 | 58 |
| Neobioscience Co., Ltd. | -- | info@neobioscience.com | CHINA | 6192 | 58 |
| Riedel-de Haen AG | -- | United States | 6624 | 87 | |
| BD Biosciences | -- | United States | 5012 | 82 | |
| Chemicon Internatinal, Inc. | -- | custserv@chemicon.com | United States | 4174 | 65 |
| Upstate | -- | info@upstate.com | United States | 876 | 76 |
| Supplier | Advantage |
|---|---|
| Atlas antibodies | 58 |
| Merck KGaA | 58 |
| Neobioscience Co., Ltd. | 58 |
| Riedel-de Haen AG | 87 |
| BD Biosciences | 82 |
| Chemicon Internatinal, Inc. | 65 |
| Upstate | 76 |
