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c-met-IN-1
- CAS No.
- 2084836-84-8
- Chemical Name:
- c-met-IN-1
- Synonyms
- c-met-IN-1;cmetIN1,c met IN 1;1H-Imidazole-4-carboxamide, N-[3-fluoro-4-[[6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]-4-quinolinyl]oxy]phenyl]-1-(2-methoxyphenyl)-
- CBNumber:
- CB88054342
- Molecular Formula:
- C35H37FN6O5
- Molecular Weight:
- 640.7
- MDL Number:
- MFCD32174239
- MOL File:
- 2084836-84-8.mol
Last updated:2023-05-21 10:59:17
c-met-IN-1 Chemical Properties,Uses,Production
Description
c-met-IN-1 (compound 16) is a potent and selective c-Met inhibitor, with IC50 of 1.1 nM, with antitumor activity.[1]. IC50: 1.1 nM (c-Met)[1]
c-met-IN-1 (compound 16) exhibits high selectivity and remarkable cytotoxicity against HT-29, MKN-45 and A549 cells with IC50 values of 0.08 μM, 0.22 μM and 0.07 μM, respectively[1].
References
[1]. Wang X, et al. Design, synthesis and biological evaluation of novel 4-(2-fluorophenoxy)quinoline derivatives as selective c-Met inhibitors. Bioorg Med Chem. 2017 Feb 1;25(3):886-896.
c-met-IN-1 Preparation Products And Raw materials
Raw materials
Preparation Products
c-met-IN-1 Suppliers
Global( 4)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Sichuan Wei Keqi Biological Technology Co., Ltd. | 028-81700200 18116577057 | 3003855609@qq.com | China | 7892 | 56 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 15801484223 | psaitong@jm-bio.com | China | 29834 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24131 | 58 |
| Supplier | Advantage |
|---|---|
| TargetMol Chemicals Inc. | 58 |
| Sichuan Wei Keqi Biological Technology Co., Ltd. | 56 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 58 |
| TargetMol Chemicals Inc. | 58 |
c-met-IN-1
cmetIN1,c met IN 1
1H-Imidazole-4-carboxamide, N-[3-fluoro-4-[[6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]-4-quinolinyl]oxy]phenyl]-1-(2-methoxyphenyl)-
2084836-84-8